Multiphoton imaging of perineural invasion in breast cancer

2019 ◽  
Author(s):  
Wenjiao Ren ◽  
Wenhui Guo ◽  
Deyong Kang ◽  
Chuan Wang ◽  
Jianxin Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Perineural Invasion ◽  
Multiphoton Imaging

scholarly journals Perineural invasion as a risk factor for locoregional recurrence of invasive breast cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Priyanka Narayan ◽  
Jessica Flynn ◽  
Zhigang Zhang ◽  
Erin F. Gillespie ◽  
Boris Mueller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Cancer Patients ◽  
Invasive Breast Cancer ◽  
Locoregional Recurrence ◽  
Perineural Invasion ◽  
Definitive Treatment ◽  
Breast Cancers ◽  
Breast Cancer Patients

AbstractPerineural invasion (PNI) is a pathologic finding observed across a spectrum of solid tumors, typically with adverse prognostic implications. Little is known about how the presence of PNI influences locoregional recurrence (LRR) among breast cancers. We evaluated the association between PNI and LRR among an unselected, broadly representative cohort of breast cancer patients, and among a propensity-score matched cohort. We ascertained breast cancer patients seen at our institution from 2008 to 2019 for whom PNI status and salient clinicopathologic features were available. Fine-Gray regression models were constructed to evaluate the association between PNI and LRR, accounting for age, tumor size, nodal involvement, estrogen receptor (ER), progesterone receptor (PR), HER2 status, histologic tumor grade, presence of lymphovascular invasion (LVI), and receipt of chemotherapy and/or radiation. Analyses were then refined by comparing PNI-positive patients to a PNI-negative cohort defined by propensity score matching. Among 8864 invasive breast cancers, 1384 (15.6%) were noted to harbor PNI. At a median follow-up of 6.3 years, 428 locoregional recurrence events were observed yielding a 7-year LRR of 7.1% (95% CI 5.5–9.1) for those with PNI and 4.7% (95% CI 4.2–5.3; p = 0.01) for those without. On univariate analysis throughout the entire cohort, presence of PNI was significantly associated with an increased risk of LRR (HR 1.39, 95% CI 1.08–1.78, p < 0.01). Accounting for differences in salient clinicopathologic and treatment parameters by multivariable Fine-Gray regression modeling, the association between PNI and LRR was potentiated (HR 1.57, 95% CI 1.2–2.07, p = 0.001). We further conducted propensity score matching to balance clinicopathologic parameters and treatments between the two groups (PNI vs not), again showing a similar significant association between PNI and LRR (HR 1.46, 95% CI 1.03–2.08, p = 0.034). PNI is significantly associated with LRR following the definitive treatment of invasive breast cancer. The excess risk conferred by PNI is similar in magnitude to that observed with LVI, or by ER/PR negativity. Breast cancer prognostication and therapeutic decision-making should consider the presence of PNI among other salient risk factors. Larger studies among more uniform breast cancer presentations may elucidate the extent to which these findings apply across breast cancer subtypes and stages.

Association of higher proliferation of Ki67 with unfavorable prognostic factors and shorter survival in breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e11083-e11083
Author(s):  
Saadettin Kilickap ◽  
Yalcin Kaya ◽  
Birsen Yucel ◽  
Ersin Tuncer ◽  
Sahande Elagoz
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Lymph Node Involvement ◽  
Free Survival ◽  
Ki67 Expression ◽  
Node Involvement ◽  
The Mean ◽  
Estrogen Receptor Negativity

e11083 Background: The prognostic value of Ki67 expression level is yet unclear in breast cancer (BC). The aim of this study was to investigate the association between Ki67 expression levels and other prognostic factors in BC. Methods: Demographic, clinical and pathological features of the pts were retreived from the hospital records. Results: In this study, 163 pts with BC were analyzed. The mean age of the pts was 53.4±12.2 years. Median Ki67 level was 20% in this study. Ki67-high tumors were significantly associated with high grade (p<0.001), lymphovascular invasion (p=0.001), estrogen receptor negativity (ER-) (p=0.035), Her2 (+) (p=0.001), advanced stage (p<0.001) and lymph node involvement (LNI) (p<0.003) of the tumor. There was no relationship between the age, perineural invasion, progesterone receptor and Ki67 positivity. Lower Ki67 levels were significantly associated with longer median relaps-free survival (RFS) compared to those of higher Ki67 levels (p=0.008). The overall survival (OS) was longer in pts with lower Ki67 levels than those with higher levels (p=0.017). Conclusions: High Ki67 expression was associated with ER-, Her2 (+), higher grade and LNI in BC. The level of Ki67 expression was a prognostic factor predicting the RFS and OS in BC pts. [Table: see text]

scholarly journals Use of preoperative mammography, ultrasonography, and MRI to predict nipple areolar complex involvement in breast cancer

2019 ◽  
Vol 92 (1102) ◽  
pp. 20190074 ◽  
Author(s):  
Soyeoun Lim ◽  
Gyeongmin Park ◽  
Hye-jeong Choi ◽  
Woon Jung Kwon ◽  
Byeong Seong Kang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Imaging Findings ◽  
Nipple Areolar Complex ◽  
Areolar Complex ◽  
Imaging Results ◽  
Relation Type

Objective: To identify the predictive factors of cancer invading into the nipple. Methods: Patients with breast cancer undergoing mastectomy between May 2009 and March 2019 were reviewed retrospectively. Of these, those with breast cancer within 2 cm of the nipple areolar complex on ultrasonography were included in this study. Clinicopathological data of the primary tumor and imaging findings from mammography, ultrasonography, and MRI were compared between cases with and without nipple involvement by cancer. Results: In total, 156 of the 821 patients identified were included in the analysis. Of them, 29 had nipple involvement by cancer. Univariate analysis revealed that the following imaging results were significantly associated with nipple involvement: perineural invasion, lymphovascular invasion, lymph node metastasis; relation type between the tumor and the nipple on ultrasonography; periareolar skin thickening on mammography; and short tumor-nipple distance, continuous enhancement between the nipple and tumor, skin enhancement, and nipple enhancement on MRI. However, on multivariate logistic regression analysis, only invasion type of tumor on ultrasonography and nipple enhancement and short tumor-nipple distance on MRI were significantly correlated with nipple involvement by cancer. Conclusion: Imaging findings on preoperative mammography, ultrasonography and MRI are effective predictors for nipple involvement by cancer. Advances in knowledge: Preoperative mammography, ultrasonography, and MRI help predict nipple involvement by breast cancer.

scholarly journals If You Don’t Look, You Won’t See: Intravital Multiphoton Imaging of Primary and Metastatic Breast Cancer

2012 ◽  
Vol 17 (2) ◽  
pp. 125-129 ◽  
Author(s):  
Laura Bonapace ◽  
Jeffrey Wyckoff ◽  
Thomas Oertner ◽  
Jacco Van Rheenen ◽  
Tobias Junt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Multiphoton Imaging

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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