Study on the prevention and treatment of ulcerative colitis and antioxidant activity of allium macrostemon powder

Author(s):  
Zicong Wu ◽  
Zhenling Zhao ◽  
Tongsheng Chen ◽  
Yifei Wang ◽  
Zhi-Ping Wang
2018 ◽  
Vol 18 (7) ◽  
pp. 985-992 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Ertan Kucuksayan ◽  
Rana Cagla Akduman ◽  
Tomris Ozben

This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Its physiological functions relate principally to the interaction of G Protein-Coupled MT1 and MT2 trans-membrane receptors (GPCRs), a family of guanidine triphosphate binding proteins. MLT has been demonstrated to suppress the growth of various tumours both, in vivo and in vitro. In this review, we analyze in depth, the antioxidant activity of melatonin, aiming to illustrate the cancer treatment potential of the molecule, by limiting or reversing the changes occurring during cancer development and growth.


2014 ◽  
Vol 4 (4) ◽  
pp. 203-217 ◽  
Author(s):  
Arpit Saxena ◽  
Kamaljeet Kaur ◽  
Shweta Hegde ◽  
Faizan M. Kalekhan ◽  
Manjeshwar Shrinath Baliga ◽  
...  

2012 ◽  
Vol 19 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Xiaoming Deng ◽  
Sandor Szabo ◽  
Tetyana Khomenko ◽  
Ganna Tolstanova ◽  
Brankica Paunovic ◽  
...  

2003 ◽  
Vol 1 (2) ◽  
pp. 14-17 ◽  
Author(s):  
Wu Huan-gan ◽  
An Guang-qing ◽  
Liu Hui-rong ◽  
Shi Zheng ◽  
Chen Han-ping ◽  
...  

2012 ◽  
Vol 19 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Xiaoming Deng ◽  
Sandor Szabo ◽  
Tetyana Khomenko ◽  
Ganna Tolstanova ◽  
Brankica Paunovic ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
H. R. Tufts ◽  
C. S. Harris ◽  
Z. N. Bukania ◽  
T. Johns

Background.Inflammation, together with related oxidative stress, is linked with the etiology of kwashiorkor, a form of severe acute malnutrition in children. A diet rich in anti-inflammatory and antioxidant phytochemicals may offer potential for the prevention and treatment of kwashiorkor. We selected and assayed five leafy green vegetables, two wild fruits, and six medicinal plants from Kenya for their antioxidant and anti-inflammatory properties. Consensus regarding medicinal plant use was established from ethnobotanical data.Methods. Antioxidant activity and phenolic content were determined using the oxygen radical absorbance capacity (ORAC) assay and Folin-Ciocalteu procedure, respectively. Anti-inflammatory activity was assessedin vitrotargeting the inflammatory mediator tumour necrosis factor-alpha (TNF-α).Results. Mangifera indica(leaves used medicinally) showed the greatest antioxidant activity (5940 ± 632 µM TE/µg) and total phenolic content (337 ± 3 mg GAE/g) butAmaranthus dubius(leafy vegetable) showed the greatest inhibition of TNF-α(IC50= 9 ± 1 μg/mL), followed byOcimum americanum(medicinal plant) (IC50= 16 ± 1 μg/mL). Informant consensus was significantly correlated with anti-inflammatory effects among active medicinal plants (r2=0.7639, P=0.0228).Conclusions. Several plant species commonly consumed by Kenyan children possess activity profiles relevant to the prevention and treatment of kwashiorkor and warrant further investigation.


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