Antimicrobial photodynamic therapy mediated by chlorin e-6 photosensitizer against Streptococcus mutans biofilm (Conference Presentation)

2019 ◽  
Author(s):  
Alessandra Nara de Souza Rastelli ◽  
Adilson César Abreu Bernardi ◽  
Camila Rodero ◽  
Marlus Chorilli ◽  
Kléber Thiago de Oliveira ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
Antimicrobial Photodynamic Therapy

Antimicrobial photodynamic therapy using a plaque disclosing solution on Streptococcus mutans

2019 ◽  
Vol 26 ◽  
pp. 252-257
Author(s):  
Yukako Shiotsu-Ogura ◽  
Ayaka Yoshida ◽  
Powen Kan ◽  
Haruka Sasaki ◽  
Toshizo Toyama ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
Antimicrobial Photodynamic Therapy

Effects of sub-lethal dose of antimicrobial photodynamic therapy on major virulence traits of Streptococcus mutans

2020 ◽  
Vol 32 ◽  
pp. 102044
Author(s):  
Shima Afrasiabi ◽  
Maryam Pourhajibagher ◽  
Nasim Chiniforush ◽  
Mahdi Aminian ◽  
Samaneh Sadat Rasi Varaei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
Lethal Dose ◽  
Antimicrobial Photodynamic Therapy ◽  
Virulence Traits

Antimicrobial photodynamic therapy on Streptococcus mutans is altered by glucose in the presence of methylene blue and red LED

2017 ◽  
Vol 19 ◽  
pp. 1-4 ◽  
Author(s):  
Cintia R. Lima Leal ◽  
Letícia H. Alvarenga ◽  
Tamires Oliveira-Silva ◽  
Ilka T. Kato ◽  
Bianca Godoy-Miranda ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
Antimicrobial Photodynamic Therapy ◽  
Red Led

Viability study of antimicrobial photodynamic therapy using curcumin, hypericin and photogem photosensitizers in planktonic cells of Streptococcus mutans

2015 ◽  
Vol 2 ◽  
pp. 22-27
Author(s):  
Fernando Luis Esteban Florez ◽  
Marina Constante Gabriel Del Arco ◽  
Sergio Luis de Souza Salvador ◽  
Vanderlei Salvador Bagnato ◽  
Osmir Batista de Oliveira Junior
Keyword(s):  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
Antimicrobial Photodynamic Therapy ◽  
Planktonic Cells ◽  
Viability Study

scholarly journals Propolis nanoparticle enhances the potency of antimicrobial photodynamic therapy against Streptococcus mutans in a synergistic manner

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shima Afrasiabi ◽  
Maryam Pourhajibagher ◽  
Nasim Chiniforush ◽  
Abbas Bahador
Keyword(s):  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
Biofilm Formation ◽  
Synergistic Effects ◽  
Fibroblast Cell ◽  
Human Gingival Fibroblast ◽  
Gingival Fibroblast ◽  
Antimicrobial Photodynamic Therapy ◽  
The Individual

Abstract Less invasive removal approaches have been recommended for deep caries lesions. Antimicrobial photodynamic therapy (aPDT) and propolis nanoparticle (PNP) are highlighted for the caries management plan. Evidence is lacking for an additive effect of combination PNP with photosensitizer (PS) in aPDT. This study aimed to investigate the individual and synergistic effects of chlorophyllin-phycocyanin mixture (PhotoActive+) and toluidine blue O (TBO) as PSs in combination with PNP in the aPDT process (aPDTplus) against major important virulence factors of Streptococcus mutans. Following characterization, biocompatibility of the PSs alone, or in combination with PNP were investigated on human gingival fibroblast cell. The in vitro synergy of PhotoActive+ or TBO and PNP was evaluated by the checkerboard method. The bacteria's virulence properties were surveyed in the presence of the PSs, individually as well as in combination. When the PSs were examined in combination (synergistic effect, FIC Index < 0.5), a stronger growth inhibitory activity was exhibited than the individual PSs. The biofilm formation, as well as genes involved in biofilm formation, showed greater suppression when the PSs were employed in combination. Overall, the results of this study suggest that the combination of PhotoActive+ or TBO with PNP with the least cytotoxicity effects and the highest antimicrobial activites would improve aPDT outcomes, leading to synergistic effects and impairing the virulence of S. mutans.

scholarly journals Phenalen-1-One-Mediated Antimicrobial Photodynamic Therapy and Chlorhexidine Applied to a Novel Caries Biofilm Model

2018 ◽  
Vol 52 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Fabian Cieplik ◽  
Fabian Wimmer ◽  
Denise Muehler ◽  
Thomas Thurnheer ◽  
Georgios N. Belibasakis ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Streptococcus Mutans ◽  
High Throughput ◽  
High Throughput Screening ◽  
Antimicrobial Efficacy ◽  
Antimicrobial Photodynamic Therapy ◽  
Actinomyces Naeslundii ◽  
Biofilm Model ◽  
Pronounced Reduction

Antimicrobial photodynamic therapy (aPDT) may be useful as a supportive antimicrobial measure for caries-active subjects. In this study, the antimicrobial efficacy of aPDT with a phenalen-1-one photosensitizer was evaluated in a novel in vitro biofilm model comprising Actinomyces naeslundii, Actinomyces odontolyticus, and Streptococcus mutans and was compared to chlorhexidine. The proposed biofilm model allows high-throughput screening for antimicrobial efficacy while exhibiting a differentiated response to different antimicrobial approaches. While chlorhexidine 0.2% showed a reduction of ≈4 log10 for all species, aPDT led to a more pronounced reduction of S. mutans (2.8 log10) than of Actinomyces spp. (1.2 or 1.3 log10). A similar effect was also observed in monospecies biofilms. Therefore, aPDT may be more effective against S. mutans than against Actinomyces spp. when in biofilms, and this antimicrobial approach merits further investigations.

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