Time-domain diffuse correlation spectroscopy quantifies path-length-resolved dynamical properties of a layered turbid media

2019 ◽  
Author(s):  
Saeed Samaei ◽  
Dawid Borycki ◽  
Michal Kacprzak ◽  
Piotr Sawosz ◽  
Adam Liebert
Keyword(s):  
Time Domain ◽  
Path Length ◽  
Correlation Spectroscopy ◽  
Turbid Media ◽  
Diffuse Correlation Spectroscopy ◽  
Dynamical Properties

scholarly journals Portable System for Time-Domain Diffuse Correlation Spectroscopy

2019 ◽  
Vol 66 (11) ◽  
pp. 3014-3025 ◽  
Author(s):  
Davide Tamborini ◽  
Kimberly A. Stephens ◽  
Melissa M. Wu ◽  
Parya Farzam ◽  
Andrew M. Siegel ◽  
...  
Keyword(s):  
Time Domain ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy ◽  
Portable System

scholarly journals Effects of Temporal Gating in Time Domain Diffuse Correlation Spectroscopy for Real Systems

2018 ◽  
Author(s):  
Lorenzo Colombo ◽  
Marco Pagliazzi ◽  
Sanathana Konugolu Venkata Sekar ◽  
Davide Contini ◽  
Alberto Dalla Mora ◽  
...  
Keyword(s):  
Time Domain ◽  
Correlation Spectroscopy ◽  
Diffuse Correlation Spectroscopy

In vivo time-domain diffuse correlation spectroscopy above the water absorption peak

2020 ◽  
Vol 45 (13) ◽  
pp. 3377
Author(s):  
L. Colombo ◽  
M. Pagliazzi ◽  
S. Konugolu Venkata Sekar ◽  
D. Contini ◽  
T. Durduran ◽  
...  
Keyword(s):  
Water Absorption ◽  
Time Domain ◽  
Correlation Spectroscopy ◽  
Absorption Peak ◽  
Diffuse Correlation Spectroscopy

scholarly journals Time-domain diffuse correlation spectroscopy (TD-DCS) for noninvasive, depth-dependent blood flow quantification in human tissue in vivo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Saeed Samaei ◽  
Piotr Sawosz ◽  
Michał Kacprzak ◽  
Żanna Pastuszak ◽  
Dawid Borycki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Time Domain ◽  
Human Tissue ◽  
Correlation Spectroscopy ◽  
Flow Quantification ◽  
Flow Index ◽  
Flow Measurements ◽  
Diffuse Correlation Spectroscopy ◽  
Sensing Applications

AbstractMonitoring of human tissue hemodynamics is invaluable in clinics as the proper blood flow regulates cellular-level metabolism. Time-domain diffuse correlation spectroscopy (TD-DCS) enables noninvasive blood flow measurements by analyzing temporal intensity fluctuations of the scattered light. With time-of-flight (TOF) resolution, TD-DCS should decompose the blood flow at different sample depths. For example, in the human head, it allows us to distinguish blood flows in the scalp, skull, or cortex. However, the tissues are typically polydisperse. So photons with a similar TOF can be scattered from structures that move at different speeds. Here, we introduce a novel approach that takes this problem into account and allows us to quantify the TOF-resolved blood flow of human tissue accurately. We apply this approach to monitor the blood flow index in the human forearm in vivo during the cuff occlusion challenge. We detect depth-dependent reactive hyperemia. Finally, we applied a controllable pressure to the human forehead in vivo to demonstrate that our approach can separate superficial from the deep blood flow. Our results can be beneficial for neuroimaging sensing applications that require short interoptode separation.

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