Label-free spectroscopic diagnosis of urothelial carcinoma

2019 ◽  
Author(s):  
Enrico Baria ◽  
Simone Morselli ◽  
Suresh Anand ◽  
Riccardo Fantechi ◽  
Arcangelo Sebastianelli ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Label Free

Label‐free grading and staging of urothelial carcinoma through multimodal fibre‐probe spectroscopy

2019 ◽  
Vol 12 (11) ◽  
Author(s):  
Enrico Baria ◽  
Simone Morselli ◽  
Suresh Anand ◽  
Riccardo Fantechi ◽  
Gabriella Nesi ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Label Free ◽  
Fibre Probe ◽  
Probe Spectroscopy

Label-free, mass-sensitive single-molecule imaging using interferometric scattering microscopy

2020 ◽  
Author(s):  
Nikolas Hundt
Keyword(s):  
Single Molecule ◽  
Cellular Systems ◽  
Single Molecule Imaging ◽  
Label Free ◽  
Measurement Sensitivity ◽  
Mass Distributions ◽  
Quantitative Measurements ◽  
Contrast Mechanism ◽  
Cellular Components ◽  
Scattering Signal

Abstract Single-molecule imaging has mostly been restricted to the use of fluorescence labelling as a contrast mechanism due to its superior ability to visualise molecules of interest on top of an overwhelming background of other molecules. Recently, interferometric scattering (iSCAT) microscopy has demonstrated the detection and imaging of single biomolecules based on light scattering without the need for fluorescent labels. Significant improvements in measurement sensitivity combined with a dependence of scattering signal on object size have led to the development of mass photometry, a technique that measures the mass of individual molecules and thereby determines mass distributions of biomolecule samples in solution. The experimental simplicity of mass photometry makes it a powerful tool to analyse biomolecular equilibria quantitatively with low sample consumption within minutes. When used for label-free imaging of reconstituted or cellular systems, the strict size-dependence of the iSCAT signal enables quantitative measurements of processes at size scales reaching from single-molecule observations during complex assembly up to mesoscopic dynamics of cellular components and extracellular protrusions. In this review, I would like to introduce the principles of this emerging imaging technology and discuss examples that show how mass-sensitive iSCAT can be used as a strong complement to other routine techniques in biochemistry.

403: Desmoplasia is an Independent Prognostic Indicator in Urothelial Carcinoma of the Upper Urinary Tract

2007 ◽  
Vol 177 (4S) ◽  
pp. 134-134
Author(s):  
Richard E. Zigeuner ◽  
Thomas Chromecki ◽  
Sebastian Leibl ◽  
Peter Rehak ◽  
Cord Langner
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Prognostic Indicator ◽  
Upper Urinary Tract

602: COX-2 Inhibition: A Mechanism for Increasing the Efficacy of BCG Immunotherapy for Urothelial Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 164-165
Author(s):  
Simon Dovedi ◽  
John A. Kirby ◽  
Helen Atkins ◽  
Barry R. Davies ◽  
John D. Kelly
Keyword(s):  
Urothelial Carcinoma ◽  
Bcg Immunotherapy ◽  
Cox 2

1093: Tumor Necrosis as Prognostic Indicator in Urothelial Carcinoma of the Upper Urinary Tract

2006 ◽  
Vol 175 (4S) ◽  
pp. 351-352
Author(s):  
Richard E. Zigeuner ◽  
Georg Hutterer ◽  
Thomas Chromecki ◽  
Sebastian Leibl ◽  
Peter Rehak ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Tumor Necrosis ◽  
Prognostic Indicator ◽  
Upper Urinary Tract

405: Alpha-Methylacyl-CoA Racemase (AMACR/P504S) Protein Expression in Urothelial Carcinoma of the Upper Urinary Tract Correlates with Tumour Progression

2006 ◽  
Vol 175 (4S) ◽  
pp. 132-132
Author(s):  
Richard E. Zigeuner ◽  
Sebastian Leibl ◽  
Georg Hutterer ◽  
Thomas Chromecki ◽  
Peter Rehak ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Protein Expression ◽  
Urothelial Carcinoma ◽  
Tumour Progression ◽  
Upper Urinary Tract
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