Cross-polarization OCT needle probe for combined blood vessels detection and tissue differentiation during stereotactic biopsy of brain tumors

2019 ◽  
Author(s):  
Elena B. Kiseleva ◽  
Pavel A. Shilyagin ◽  
Vladimir N. Romashov ◽  
Yulia V. Korzhimanova ◽  
Marina A. Sirotkina ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Blood Vessels ◽  
Stereotactic Biopsy ◽  
Tissue Differentiation ◽  
Cross Polarization ◽  
Needle Probe

Dual Fluorescence Emission by Irradiation of Single Optical Source for Fluorescein Sodium and 5-ALA Applications

2021 ◽  
Author(s):  
So Yoon Kwon ◽  
Ki-Cheol Yoon ◽  
Kwang Gi Kim
Keyword(s):  
Brain Tumors ◽  
Blood Vessels ◽  
Aminolevulinic Acid ◽  
Fluorescence Emission ◽  
Dual Band ◽  
Band Pass Filter ◽  
Fluorescein Sodium ◽  
Dual Fluorescence ◽  
Optical Source ◽  
Pass Filter

Abstract Most brain surgeries aim to completely resection a tumor. However, the arrangement of blood vessels around brain tumors is often complex. Moreover, the tumors and blood vessels have similar colors, making it difficult to identify the boundaries between them with the naked eye. Fluorescent staining is a method used to distinguish the borders between brain tumors and blood vessels. The fluorescent contrast agents commonly used to observe tumors are 5-aminolevulinic acid (5-ALA) and fluorescein sodium (FS), which have different surgical sensitivities, depending on the type of tumor. In this article, a dual band band-pass filter (BPF) with dual-wavelength emission for 5-ALA and FS is designed, and the dual-band BPF capable of inducing simultaneous fluorescence emission of FS and 5-ALA was investigated experimentally to improve accuracy, speed, and energy efficiency in clinical settings. The possibility of dual fluorescence emission with a single irradiation is proposed. The proposed fluorescent dual-band filter has the advantage of saving energy, reducing auxiliary manpower and unit costs, and reducing operating room space requirements by producing two fluorescence diagnostic effects using a single equipment.

Stereotactic Biopsy of Deep Brain Tumors in Infancy and Childhood

1983 ◽  
Vol 10 (2) ◽  
pp. 92-98 ◽  
Author(s):  
G. Broggi ◽  
A. Franzini ◽  
F. Migliavacca ◽  
A. Allegranza
Keyword(s):  
Brain Tumors ◽  
Stereotactic Biopsy ◽  
Infancy And Childhood ◽  
Deep Brain

Optical spectroscopy for stereotactic biopsy of brain tumors

2015 ◽  
Author(s):  
Niklas Markwardt ◽  
Anna von Berg ◽  
Sebastian Fiedler ◽  
Marcus Goetz ◽  
Neda Haj-Hosseini ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Optical Spectroscopy ◽  
Stereotactic Biopsy

Remission spectrometry for blood vessel detection during stereotactic biopsy of brain tumors

2016 ◽  
Vol 10 (8) ◽  
pp. 1080-1094 ◽  
Author(s):  
Niklas A. Markwardt ◽  
Herbert Stepp ◽  
Gerhard Franz ◽  
Ronald Sroka ◽  
Marcus Goetz ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Blood Vessel ◽  
Stereotactic Biopsy ◽  
Blood Vessel Detection ◽  
Vessel Detection

Stereotactic biopsy for multifocal, diffuse, and deep-seated brain tumors using Leksell’s system

2004 ◽  
Vol 11 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Kazumichi Yamada ◽  
Satoshi Goto ◽  
Masato Kochi ◽  
Yukitaka Ushio
Keyword(s):  
Brain Tumors ◽  
Stereotactic Biopsy

Hardware and Software Complex for Detection and Visualization of Subsurface Blood Vessels During Brain Tumors Resection

2021 ◽  
Vol 91 (3) ◽  
pp. 55-66
Author(s):  
A. M. Udeneev
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Blood Vessel ◽  
Blood Vessels ◽  
Endoscopic Resection ◽  
Near Infrared ◽  
Bovine Brain ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Different Depths

Purpose: The purpose of this work is to prove the possibility of subsurface blood vessels detection during endoscopic resection of brain tumors using the method of endoscopy in red and near infrared light. Material and methods: This work was accomplished with an experimental setup, simulating the geometry of endoscopic resection of brain tumor. The setup realizes the backlight of operational field with light from diagnostic window of electromagnetic spectrum (650 1000 nm) and takes photos of operational field. After that special algorithm increases the contrast of the photos and detect subsurface blood vessels. The pieces of bovine brain have served as brain samples. And thin-walled transparent plastic tube with an internal diameter 1 mm filled with bovine blood has served as a blood vessel. The tube was placed into brain samples on different depths. Results: During the experiments the series of photos of bovine brain with artificial blood vessels located on different depths was received. For every photo contrast was increased and blood vessel was recognized. Conclusion: The series of experiments has showed the possibility to detect the blood vessels with outer diameter 1 mm in the depth of 2 mm and 3 mm in brain tissues using the method of endoscopy in red and near infrared light. The depth of 3 mm is enough for preliminary detection of blood vessel during the endoscopic resection of brain tumor.

Sites of Origin of Primary Intracerebral Malignant Lymphoma

Neurosurgery ◽  
1989 ◽  
Vol 25 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Shobu Shibata
Keyword(s):  
White Matter ◽  
Brain Tumors ◽  
Malignant Lymphoma ◽  
Choroid Plexus ◽  
Blood Vessels ◽  
Tumor Cells ◽  
Subarachnoid Space ◽  
Periventricular White Matter ◽  
Metastatic Brain Tumors ◽  
Lymphoma Cells

Abstract With the aim of finding characteristics pointing to the primary site, computed tomography examination from 9 patients with primary brain malignant lymphoma (non-Hodgkin's lymphoma originating in the central nervous system, NHL-CNS) (5 single, 4 multiple lesions) were analyzed. The tumors were usually situated in the basal ganglia, corpus callosum, or cerebellum and were always in contact with either the ependyma of the ventricles or the subarachnoid space. Tumors with widespread infiltration of white matter surrounding the ventricles were characteristic of NHL-CNS. Microscopic examination of 3 autopsy cases revealed infiltration of the subependymal layer of the lateral ventricles and the third and fourth ventricles by lymphoma cells. The entire extent of the choroid plexus was invaded by tumor cells. There were multiple foci of similar cells invading the periventricular white matter. The subarachnoid space was filled with lymphoma cells. In many areas the Virchow-Robin spaces and pial-glial membranes were disrupted, and invasion of the underlying gray matter by tumor cells was seen. The ultrastructure of the blood vessels of NHL-CNS was compared with those in glial, nonglial, and metastatic brain tumors. The essential feature in NHL-CNS was fenestrated vessels. They resembled the blood vessels found in nonglial and metastatic brain tumors, but were distinctly different from those seen in glial tumors with nonfenestrated vessels. Although the following scheme in proposed with reservations, it could account for the sites of origin of NHL-CNS: lymphocytes located in the choroid plexus stroma or the subarachnoid space are activated, caused to proliferate, and finally become neoplastic. Then these cells migrate through the underlying parenchyma along the Virchow-Robin spaces and multiply until they present themselves as primary brain tumors.

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