Developing a computer-aided image analysis and visualization tool to predict region-specific brain tissue “at risk” for developing acute ischemic stroke

2019 ◽  
Author(s):  
Gopichandh Danala ◽  
Morteza Heidari ◽  
Faranak Aghaei ◽  
Bappaditya Ray ◽  
Bin Zheng
Keyword(s):  
At Risk ◽  
Image Analysis ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Brain Tissue ◽  
Visualization Tool ◽  
Computer Aided

scholarly journals Emergency Extracranial-Intracranial Bypass to Revascularize Salvageable Brain Tissue in Acute Ischemic Stroke Patients

2018 ◽  
Vol 109 ◽  
pp. e476-e485 ◽  
Author(s):  
Jan-Karl Burkhardt ◽  
Sebastian Winklhofer ◽  
Jorn Fierstra ◽  
Susanne Wegener ◽  
Giuseppe Esposito ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Brain Tissue ◽  
Stroke Patients

Abstract 1941: Level and Value of Circulating Endothelial Progenitor Cells in Patients after Acute Ischemic Stroke

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Yip Hon-Kan
Keyword(s):  
At Risk ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Neurological Impairment ◽  
Systemic Circulation ◽  
Endothelial Progenitor ◽  
Tissue Ischemia ◽  
Severe Neurological Impairment

Background and Purpose Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for in situ angiogenesis. This study tested the hypothesis that the level of circulating EPCs is substantially increased and predictive of prognostic outcomes after acute ischemic stroke. Methods The level of circulating EPCs [staining markers: CD31/CD34 (E 1 ), CD62E/CD34 (E 2 ) and KDR/CD34 (E 3 )] was examined using flow cytometry at 48 h after acute ischemic stroke in 138 consecutive patients. The EPC level was also evaluated once in twenty healthy volunteers and in forty at-risk controls. Results Level of circulating EPCs (E 1–3 ) was significantly higher in ischemic stroke patients than in at-risk control subjects ( p <0.05). Additionally, EPC (E 1–3 ) level was significantly lower in patients with severe neurological impairment [defined as a score ≥12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe impairment (NIHSS < score 12) at 48 h after ischemic stroke ( p <0.0001). Moreover, the EPC (E 3 ) level was strongly correlated with improved NIHSS ≥ 4 on day 21 after ischemic stroke ( p =0.0004). Furthermore, low circulating EPC level was independently predictive of severe neurological impairment (NIHSS ≥ 12) at 48 h (E 1–3 ) and combined major adverse clinical outcomes (defined as recurrent ischemic stroke, any cause of death, or NIHSS of ≥ 12) on day 90 (E 1 ) following ischemic stroke ( p <0.001). Conclusions Level of circulating EPCs is independently predictive of prognosis after ischemic stroke.

Abstract WMP24: Reperfusion Into Severely Damaged Brain Tissue is Associated With Impending Parenchymal Hemorrhage in Acute Ischemic Stroke Patients

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Songlin Yu ◽  
Samantha J Ma ◽  
David S Liebeskind ◽  
Lirong Yan ◽  
Fabien Scalzo ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Brain Tissue ◽  
Stroke Patients

Acute ischemic stroke diagnosis using brain tissue pulsations

2020 ◽  
Vol 419 ◽  
pp. 117164
Author(s):  
Jonathan Ince ◽  
Caroline Banahan ◽  
Sara Venturini ◽  
Meshal Alharbi ◽  
Poppy Turner ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Brain Tissue ◽  
Stroke Diagnosis

scholarly journals Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0225841 ◽  
Author(s):  
Seán Fitzgerald ◽  
Shunli Wang ◽  
Daying Dai ◽  
Dennis H. Murphree ◽  
Abhay Pandit ◽  
...  
Keyword(s):  
Machine Learning ◽  
Image Analysis ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Blood Clots ◽  
Learning Software

Dielectric properties of brain tissue at 1 GHz in acute ischemic stroke: Experimental study on swine

2016 ◽  
Vol 38 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Serguei Semenov ◽  
Toan Huynh ◽  
Thomas Williams ◽  
Brian Nicholson ◽  
Anna Vasilenko
Keyword(s):  
Experimental Study ◽  
Ischemic Stroke ◽  
Dielectric Properties ◽  
Acute Ischemic Stroke ◽  
Brain Tissue

scholarly journals Infarct Progression in the Early and Late Phases of Acute Ischemic Stroke

Neurology ◽  
2021 ◽  
Vol 97 (20 Supplement 2) ◽  
pp. S60-S67
Author(s):  
Hamidreza Saber ◽  
David S. Liebeskind
Keyword(s):  
At Risk ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Late Phase ◽  
Functional Independence ◽  
Irreversible Damage ◽  
Ischemic Tissue ◽  
Underlying Pathophysiology ◽  
Core Infarct ◽  
Brain Energy

Purpose of ReviewTo explore factors associated with infarct progression in the early and late phase of acute ischemic stroke in patients undergoing endovascular therapy.Recent FindingsFollowing ischemic stroke, brain injury can progress at a variable rate, at the expense of “penumbral tissue,” which is the ischemic tissue at risk of infarction. Despite dramatic advances in endovascular stroke therapies with early revascularization in more than 80% of cases, nearly half of patients do not achieve functional independence despite successful recanalization. This is largely attributed to the irreversible damage that is already extensive at the time of revascularization.SummaryThe underlying pathophysiology and determinants of the core infarct progression are complex and multifactorial, depending on a balance between brain energy consumption and collateral perfusion supply. It is crucial to develop creative and individualized theranostics to predict infarct progression and to “freeze” the tissue at risk prior to recanalization.

scholarly journals A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia

2000 ◽  
Vol XXXII (3-4) ◽  
pp. 76-76
Author(s):  
J. Yrjanheikki ◽  
T. Tikka ◽  
R. Keinanen ◽  
G. Goldsteins ◽  
P. H. Chan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Acute Ischemic Stroke ◽  
Brain Tissue ◽  
Focal Cerebral Ischemia ◽  
The Brain ◽  
Tetracycline Derivative

One of the reasons for the insufficient effectiveness of treatment of acute ischemic stroke may be secondary inflammation of the brain tissue, which, according to the results of modern studies, significantly worsens the consequences and outcome of the disease.

scholarly journals Reperfusion Into Severely Damaged Brain Tissue Is Associated With Occurrence of Parenchymal Hemorrhage for Acute Ischemic Stroke

2020 ◽  
Vol 11 ◽  
Author(s):  
Songlin Yu ◽  
Samantha J. Ma ◽  
David S. Liebeskind ◽  
Xin J. Qiao ◽  
Lirong Yan ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Brain Tissue
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