Gold nanoprisms enhanced optical coherence tomography angiography of live animals in the second near infrared window (Conference Presentation)

2019 ◽  
Author(s):  
Peng Si ◽  
Edwin Yuan ◽  
Orly Liba ◽  
Yonatan Winetraub ◽  
Siavash Yousefi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Near Infrared ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Gold Nanoprisms ◽  
Infrared Window

scholarly journals Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 11986-11994 ◽  
Author(s):  
Peng Si ◽  
Edwin Yuan ◽  
Orly Liba ◽  
Yonatan Winetraub ◽  
Siavash Yousefi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Contrast Agents ◽  
Near Infrared ◽  
Optical Coherence ◽  
Gold Nanoprisms ◽  
Infrared Window

scholarly journals Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near Infrared Window for Enhanced Angiography in Live Animals

2018 ◽  
Author(s):  
Peng Si ◽  
Edwin Yuan ◽  
Orly Liba ◽  
Yonatan Winetraub ◽  
Siavash Yousefi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Contrast Agents ◽  
Near Infrared ◽  
Mouse Skin ◽  
Optical Coherence ◽  
Vascular Networks ◽  
Gold Nanoprisms ◽  
Dynamic Scattering ◽  
Infrared Window

ABSTRACTOptical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived from the movements of red blood cells (RBCs). However, the low hematocrit and long latency between RBCs in capillaries makes these OCTA signals discontinuous, leading to incomplete mapping of the vascular networks. OCTA imaging of microvascular circulation is particularly challenging in tumors due to the abnormally slow blood flow in angiogenic tumor vessels and strong attenuation of light by tumor tissue. Here we demonstrate in vivo that gold nanoprisms (GNPRs) can be used as OCT contrast agents working in the second near infrared window, significantly enhancing the dynamic scattering signals in microvessels and improving the sensitivity of OCTA in skin tissue and melanoma tumors in live mice. This is the first demonstration that nanoparticle-based OCT contrast agent work in vivo in the second near infrared window, which allows deeper imaging depth by OCT. With GNPRs as contrast agents, the post-injection OCT angiograms showed 41% and 59% more microvasculature than pre-injection angiograms in healthy mouse skin and melanoma tumors, respectively. By enabling better characterization of microvascular circulation in vivo, GNPR-enhanced OCTA could lead to better understanding of vascular functions during pathological conditions, more accurate measurements of therapeutic response, and improved patient prognoses.

scholarly journals Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

2019 ◽  
Vol 244 (10) ◽  
pp. 813-818 ◽  
Author(s):  
Taeyoon Son ◽  
Minhaj Alam ◽  
Tae-Hoon Kim ◽  
Changgeng Liu ◽  
Devrim Toslak ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Near Infrared ◽  
Optical Coherence Tomography Angiography ◽  
Imaging Modality ◽  
Retinal Diseases ◽  
Optical Coherence ◽  
Tomography Imaging ◽  
Vessel Tracking ◽  
Optical Coherence Tomography Imaging ◽  
Arteries And Veins

Differential artery–vein analysis is valuable for early detection of diabetic retinopathy and other eye diseases. As a new optical coherence tomography imaging modality, optical coherence tomography angiography provides capillary level resolution for accurate examination of retinal vasculatures. However, differential artery–vein analysis in optical coherence tomography angiography particularly for macular region in which blood vessels are small is challenging. In coordination with an automatic vessel tracking algorithm, we report here the feasibility of using near infrared optical coherence tomography oximetry to guide artery–vein classification in optical coherence tomography angiography of macular region. Impact statement It is known that arteries and veins can be affected by retinal diseases differently. Therefore, quantitative artery–vein analysis holds the promise for better disease detection and treatment evaluation. However, clinical optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) instruments lack the function of differential artery–vein analysis. Here, we report the feasibility of near infrared OCT oximetry-guided artery–vein classification in OCTA. Because the OCT and OCTA are naturally captured from the same instrument simultaneously, the presented method is feasible for practical deployment of differential artery–vein analysis in OCTA.

scholarly journals Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marco Nassisi ◽  
Carlo Lavia ◽  
Saddek Mohand-Said ◽  
Vasily Smirnov ◽  
Aline Antonio ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinitis Pigmentosa ◽  
Near Infrared ◽  
Optical Coherence Tomography Angiography ◽  
Structural Integrity ◽  
Fundus Autofluorescence ◽  
Central Area ◽  
Disease Status ◽  
Optical Coherence ◽  
Swept Source

AbstractThirty-eight patients from 37 families with retinitis pigmentosa (RP) underwent macular 6 × 6-mm swept-source optical coherence tomography angiography (SS-OCTA) and 30° near-infrared fundus autofluorescence (NIR-FAF) acquisitions in one eye. Superficial vascular complex (SVC), deep capillary complex (DCC) and choriocapillaris (CC) angiograms were registered with NIR-FAF acquisitions to comparatively assess subjects with and without central area of preserved NIR-FAF (APA). On the subset of patients showing an APA, the vessel densities for SVC and DCC and flow deficits for CC were assessed in three directions (superior, inferior and temporal) from the fovea and compared to healthy 1:1 age-matched controls. Nine patients with no APA had evidence of severe central OCTA alterations at all levels, especially in the DCC. In the other 29 subjects presenting APA, all OCTA parameters were similar to healthy eyes within the APA, where the retina preserves its structural integrity. Outside the APA, both the DCC and CC were significantly reduced in all directions. These alterations are probably related to the outer retinal atrophy outside the APA. Comparing OCTA to other imaging modalities is helpful to determine the potential interest of OCTA findings as an outcome measure for disease status and progression.

scholarly journals Optical coherence tomography angiography monitors human cutaneous wound healing over time

2018 ◽  
Vol 8 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Anthony J. Deegan ◽  
Wendy Wang ◽  
Shaojie Men ◽  
Yuandong Li ◽  
Shaozhen Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Over Time
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