Fabrication and simulation of silver nanostructures on different types of porous silicon for surface enhanced Raman spectroscopy

2019 ◽  
Author(s):  
Sergey Redko ◽  
Alexey Dolgiy ◽  
Dmitri Zhygulin ◽  
Viktar Khaliava ◽  
Nadia Khinevich ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Porous Silicon ◽  
Surface Enhanced Raman Spectroscopy ◽  
Silver Nanostructures ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman

scholarly journals Label-Free Detection of Human Serum Using Surface-Enhanced Raman Spectroscopy Based on Highly Branched Gold Nanoparticle Substrates for Discrimination of Non-Small Cell Lung Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Xiaowei Cao ◽  
Zhenyu Wang ◽  
Liyan Bi ◽  
Jie Zheng
Keyword(s):  
Lung Cancer ◽  
Raman Spectroscopy ◽  
Cell Lung Cancer ◽  
Surface Enhanced Raman Spectroscopy ◽  
Small Cell ◽  
Label Free ◽  
Small Cell Lung ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman

Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on serum in screening tests. In this study, a potential label-free serum test based on SERS spectroscopy was developed to analyze human serum for the diagnosis of the non-small cell lung cancer (NSCLC). We firstly synthesized novel highly branched gold nanoparticles (HGNPs) at high yield through a one-step reduction of HAuCl4 with dopamine hydrochloride at 60°C. Then, HGNP substrates with good reproducibility, uniformity, and high SERS effect were fabricated by the electrostatically assisted (3-aminopropyl) triethoxysilane-(APTES-) functionalized silicon wafer surface-sedimentary self-assembly method. Using as-prepared HGNP substrates as a high-performance sensing platform, SERS spectral data of serum obtained from healthy subjects, lung adenocarcinoma patients, lung squamous carcinoma patients, and large cell lung cancer patients were collected. The difference spectra among different types of NSCLC were compared, and analysis result revealed their intrinsic difference in types and contents of nucleic acids, proteins, carbohydrates, amino acids, and lipids. SERS spectra were analyzed by principal component analysis (PCA), which was able to distinguish different types of NSCLC. Considering its time efficiency, being label-free, and sensitivity, SERS based on HGNP substrates is very promising for mass screening NSCLC and plays an important role in the detection and prevention of other diseases.

Nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications

2017 ◽  
Author(s):  
Anil K. Kodali ◽  
Rohit Bhargava
Keyword(s):  
Raman Spectroscopy ◽  
Biomedical Applications ◽  
Spectroscopic Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Ultrasensitive Detection ◽  
Optical Resonances ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman ◽  
Ir And Raman

This article describes the use of nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications. Engineered probes and surfaces are promising tools for enhancing signals for ultrasensitive detection of diseases like carcinoma. Two methods of interest are surface-enhanced infrared absorption (SEIRA) spectroscopy and surface-enhanced Raman spectroscopy (SERS) for IR and Raman modalities, respectively. SERS and SEIRA can be broadly categorized under a common modality termed surface-enhanced vibrational spectroscopy. This article first reviews various breakthrough findings reported in SERS and SEIRA, along with different types ofsubstrates and contrast agents used in realizing the enhancement and theories proposed to explain these findings. It then considers the configurations of nano-LAMPs and presents example results demonstrating their optical resonances and tunability. Finally, it evaluates a few techniques for fabricating multilayered nanoparticles and highlights some issues with respect to fabrication.

Silicon Nanowires Coated with Silver Nanostructures as Ultrasensitive Interfaces for Surface-Enhanced Raman Spectroscopy

2009 ◽  
Vol 1 (7) ◽  
pp. 1396-1403 ◽  
Author(s):  
Elisabeth Galopin ◽  
Jacques Barbillat ◽  
Yannick Coffinier ◽  
Sabine Szunerits ◽  
Gilles Patriarche ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Silicon Nanowires ◽  
Surface Enhanced Raman Spectroscopy ◽  
Silver Nanostructures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface Enhanced Raman Spectroscopy for DNA Biosensors—How Far Are We?

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4423 ◽  
Author(s):  
Edyta Pyrak ◽  
Jan Krajczewski ◽  
Artur Kowalik ◽  
Andrzej Kudelski ◽  
Aleksandra Jaworska
Keyword(s):  
Raman Spectroscopy ◽  
Limit Of Detection ◽  
Surface Enhanced Raman Spectroscopy ◽  
Diagnostic Tools ◽  
Strong Increase ◽  
Raman Signal ◽  
Silver Nanostructures ◽  
Dna Sensors ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

A sensitive and accurate identification of specific DNA fragments (usually containing a mutation) can influence clinical decisions. Standard methods routinely used for this type of detection are PCR (Polymerase Chain Reaction, and its modifications), and, less commonly, NGS (Next Generation Sequencing). However, these methods are quite complicated, requiring time-consuming, multi-stage sample preparation, and specially trained staff. Usually, it takes weeks for patients to obtain their results. Therefore, different DNA sensors are being intensively developed by many groups. One technique often used to obtain an analytical signal from DNA sensors is Raman spectroscopy. Its modification, surface-enhanced Raman spectroscopy (SERS), is especially useful for practical analytical applications due to its extra low limit of detection. SERS takes advantage of the strong increase in the efficiency of Raman signal generation caused by a local electric field enhancement near plasmonic (typically gold and silver) nanostructures. In this condensed review, we describe the most important types of SERS-based nanosensors for genetic studies and comment on their potential for becoming diagnostic tools.

Surface-enhanced Raman spectroscopy on porous silicon membranes decorated with Ag nanoparticles integrated in elastomeric microfluidic chips

RSC Advances ◽  
2016 ◽  
Vol 6 (26) ◽  
pp. 21865-21870 ◽  
Author(s):  
Chiara Novara ◽  
Andrea Lamberti ◽  
Alessandro Chiadò ◽  
Alessandro Virga ◽  
Paola Rivolo ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Porous Silicon ◽  
Microfluidic Chip ◽  
Ag Nanoparticles ◽  
Surface Enhanced Raman Spectroscopy ◽  
Microfluidic Chips ◽  
Label Free ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Silicon Membranes

An elastomeric microfluidic chip integrating SERS active silver-coated porous silicon membranes is developed, which performs label free and calibrated SERS analysis in a multi-analyte configuration.

scholarly journals Gold Nanostructures for Surface-Enhanced Raman Spectroscopy, Prepared by Electrodeposition in Porous Silicon

Materials ◽  
2011 ◽  
Vol 4 (4) ◽  
pp. 791-800 ◽  
Author(s):  
Kazuhiro Fukami ◽  
Mohamed L. Chourou ◽  
Ryohei Miyagawa ◽  
Álvaro Muñoz Noval ◽  
Tetsuo Sakka ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Porous Silicon ◽  
Surface Enhanced Raman Spectroscopy ◽  
Gold Nanostructures ◽  
Surface Enhanced ◽  
Surface Enhanced Raman
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