Proposal and justification of a treatment protocol for extraoral photobiomodulation therapy for the prevention of oral mucositis (Conference Presentation)

2019 ◽  
Author(s):  
Ather Adnan ◽  
Wendy B. London ◽  
Christine N. Duncan ◽  
Amy F. Juliano ◽  
Stephen T. Sonis ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Treatment Protocol ◽  
Photobiomodulation Therapy

scholarly journals Photobiomodulation Therapy in the Treatment of Oral Mucositis, Dysgeusia and Oral Dryness as Side-Effects of Head and Neck Radiotherapy in a Cancer Patient: A Case Report

2018 ◽  
Vol 6 (4) ◽  
pp. 64 ◽  
Author(s):  
Marwan El Mobadder ◽  
Fadi Farhat ◽  
Wassim El Mobadder ◽  
Samir Nammour
Keyword(s):  
Case Report ◽  
Oral Mucositis ◽  
Treatment Protocol ◽  
Photobiomodulation Therapy ◽  
International Standards ◽  
World Health ◽  
Oral Dryness ◽  
Health Organization ◽  
International Standards Organization ◽  
Head And Neck Radiotherapy

Successful management of oral mucositis, dysgeusia and oral dryness was made with five sessions of photobiomodulation. The severity of oral mucositis was measured according to the World Health Organization scale for the assessment of oral mucositis. Dysgeusia testing was performed according to the International Standards Organization (ISO). For the assessment of oral dryness or hyposalivation, quantity of the total resting and stimulated saliva (Q-sal, mL/min) was measured. Photobiomodulation parameters, applications, and treatment protocol used were suggested by an international multidisciplinary panel of clinicians and researchers with expertise in the area of supportive care in cancer and/or PBM clinical application and dosimetry. This case report confirms the effectiveness of photobiomodulation therapy in the management of oral mucositis, dysgeusia, and oral dryness.

scholarly journals The Path to an Evidence-Based Treatment Protocol for Extraoral Photobiomodulation Therapy for the Prevention of Oral Mucositis

2021 ◽  
Vol 2 ◽  
Author(s):  
Ather Adnan ◽  
Anna N. Yaroslavsky ◽  
James D. Carroll ◽  
Wayne Selting ◽  
Amy F. Juliano ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Oral Mucositis ◽  
Treatment Protocol ◽  
Photobiomodulation Therapy ◽  
Evidence Based ◽  
Hematopoietic Stem ◽  
Evidence Based Treatment

Oral mucositis is a painful complication of hematopoietic stem cell transplantation for which photobiomodulation therapy (PBMT) is a safe and effective intervention. Extraoral delivery of PBMT has clinical advantages over intraoral delivery but requires additional dosimetric considerations due to the external tissue layers through which the light must propagate before reaching the oral mucosa. Additionally, to date there has been no dose modeling study, a task essential to developing a justified treatment protocol. We review here some of the complexities surrounding extraoral photobiomodulation therapy and offer that may help guide researchers toward an evidence-based treatment protocol for the prevention of oral mucositis.

Intraoral versus extraoral photobiomodulation therapy in the prevention of oral mucositis in HSCT patients: a randomized, single-blind, controlled clinical trial

2021 ◽  
Author(s):  
Mariana Bitu Ramos-Pinto ◽  
Teresa Paula de Lima Gusmão ◽  
Jayr Schmidt-Filho ◽  
Graziella Chagas Jaguar ◽  
Manoela Domingues Martins ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Oral Mucositis ◽  
Photobiomodulation Therapy ◽  
Controlled Clinical Trial ◽  
Single Blind

scholarly journals Photobiomodulation Therapy in Oral Mucositis and Potentially Malignant Oral Lesions: A Therapy Towards the Future

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1949
Author(s):  
Reem Hanna ◽  
Snehal Dalvi ◽  
Stefano Benedicenti ◽  
Andrea Amaroli ◽  
Tudor Sălăgean ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Treatment Modality ◽  
Cellular Proliferation ◽  
Tumour Progression ◽  
Controlled Trial ◽  
Photobiomodulation Therapy ◽  
Evidence Based ◽  
Oral Lesions ◽  
The Impact

Photobiomodulation therapy (PBMT) is an effective treatment modality, which has the significant advantage of enhancing a patient’s quality of life (QoL) by minimising the side effects of oral cancer treatments, as well as assisting in the management of potentially cancerous lesions. It is important to note that the major evidence-based documentation neither considers, nor tackles, the issues related to the impact of PBMT on tumour progression and on the downregulation of cellular proliferation improvement, by identifying the dose- and time-dependency. Moreover, little is known about the risk of this therapy and its safety when it is applied to the tumour, or the impact on the factor of QoL. The review aimed to address the benefits and limitations of PBMT in premalignant oral lesions, as well as the conflicting evidence concerning the relationship between tumour cell proliferation and the applied dose of photonic energy (fluence) in treating oral mucositis induced by head and neck cancer (H&N) treatments. The objective was to appraise the current concept of PBMT safety in the long-term, along with its latent impact on tumour reaction. This review highlighted the gap in the literature and broaden the knowledge of the current clinical evidence-based practice, and effectiveness, of PBMT in H&N oncology patients. As a result, the authors concluded that PBMT is a promising treatment modality. However, due to the heterogeneity of our data, it needs to undergo further testing in well-designed, long-term and randomised controlled trial studies, to evaluate it with diligent and impartial outcomes, and ensure laser irradiation’s safety at the tumour site.

Prophylactic photobiomodulation therapy using 660 nm diode laser for oral mucositis in paediatric patients under chemotherapy: 5-year experience from a Brazilian referral service

2020 ◽  
Vol 35 (8) ◽  
pp. 1857-1866
Author(s):  
Laiz Fernandes Mendes Nunes ◽  
José Alcides Almeida de Arruda ◽  
Alessandra Figueiredo Souza ◽  
Raíssa Cristina Costa Silva ◽  
Célia Regina Moreira Lanza ◽  
...  
Keyword(s):  
Diode Laser ◽  
Oral Mucositis ◽  
Photobiomodulation Therapy ◽  
Referral Service ◽  
Paediatric Patients

Photobiomodulation therapy in the management of oral mucositis: search for the optimal clinical treatment parameters

2018 ◽  
Vol 26 (10) ◽  
pp. 3319-3321 ◽  
Author(s):  
Sharon Elad ◽  
Praveen Arany ◽  
Rene-Jean Bensadoun ◽  
Joel B. Epstein ◽  
Andrei Barasch ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Clinical Treatment ◽  
Photobiomodulation Therapy

The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder

2017 ◽  
Vol 28 (4) ◽  
pp. 441-453 ◽  
Author(s):  
Farzad Salehpour ◽  
Seyed Hossein Rasta
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Near Infrared ◽  
Treatment Protocol ◽  
Photobiomodulation Therapy ◽  
Infrared Light ◽  
Major Depressive ◽  
Atp Production ◽  
Beneficial Effects ◽  
Wide Range

AbstractMajor depressive disorder is a common debilitating mood disorder that affects quality of life. Prefrontal cortex abnormalities, an imbalance in neurotransmitters, neuroinflammation, and mitochondrial dysfunction are the major factors in the etiology of major depressive disorder. Despite the efficacy of pharmacotherapy in the treatment of major depressive disorder, 30%–40% of patients do not respond to antidepressants. Given this, exploring the alternative therapies for treatment or prevention of major depressive disorder has aroused interest among scientists. Transcranial photobiomodulation therapy is the use of low-power lasers and light-emitting diodes in the far-red to near-infrared optical region for stimulation of neuronal activities. This non-invasive modality improves the metabolic capacity of neurons due to more oxygen consumption and ATP production. Beneficial effects of transcranial photobiomodulation therapy in the wide range of neurological and psychological disorders have been already shown. In this review, we focus on some issue relating to the application of photobiomodulation therapy for major depressive disorder. There is some evidence that transcranial photobiomodulation therapy using near-infrared light on 10-Hz pulsed mode appears to be a hopeful technique for treatment of major depressive disorder. However, further studies are necessary to find the safety of this method and to determine its effective treatment protocol.

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