Targeting drug-resistant glioblastoma stem cells using photodynamic therapy (Conference Presentation)

2019 ◽  
Author(s):  
Bryan Q. Spring ◽  
Kohei Watanabe ◽  
Megumi Ichikawa ◽  
Srivalleesha Mallidi ◽  
Tatsuyuki Matsudaira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Glioblastoma Stem Cells

scholarly journals p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis

2015 ◽  
Vol 11 (6) ◽  
pp. 4165-4173 ◽  
Author(s):  
WANG MIAO ◽  
XIAODONG LIU ◽  
HONGQIN WANG ◽  
YIMIN FAN ◽  
SHIZHONG LIAN ◽  
...  
Keyword(s):  
Stem Cells ◽  
Drug Resistant ◽  
Glioblastoma Stem Cells

scholarly journals Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells

2016 ◽  
Vol 79 (10) ◽  
pp. 538-545 ◽  
Author(s):  
Wen-Shin Song ◽  
Yi-Ping Yang ◽  
Chi-Shuan Huang ◽  
Kai-Hsi Lu ◽  
Wei-Hsiu Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Drug Resistant ◽  
Glioblastoma Stem Cells

Targeting glioblastoma stem cells: the first steps of photodynamic therapy

2021 ◽  
pp. 102585
Author(s):  
Lechner Rodríguez Aguilar ◽  
María Laura Vilchez ◽  
Laura N. Milla Sanabria
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Glioblastoma Stem Cells

Nano-curcumin influences blue light photodynamic therapy for restraining glioblastoma stem cells growth

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95165-95168 ◽  
Author(s):  
A. Dev ◽  
A. K. Srivastava ◽  
S. Roy Choudhury ◽  
S. Karmakar
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Blue Light ◽  
Therapeutic Potential ◽  
Glioblastoma Stem Cells

Nano-curcumin based blue light photodynamic therapy has therapeutic potential in the arsenal of glioblastoma cancer stem cells recurrence.

Targeted Delivery of Tumor Suppressor microRNA-1 by Transferrin- Conjugated Lipopolyplex Nanoparticles to Patient-Derived Glioblastoma Stem Cells

2014 ◽  
Vol 15 (9) ◽  
pp. 839-846 ◽  
Author(s):  
Xinmei Wang ◽  
Xiaomeng Huang ◽  
Zhaogang Yang ◽  
Daniel Gallego-Perez ◽  
Junyu Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Suppressor ◽  
Targeted Delivery ◽  
Glioblastoma Stem Cells

Keratin nanoparticles and photodynamic therapy enhance the anticancer stem cells activity of salinomycin

2021 ◽  
Vol 122 ◽  
pp. 111899
Author(s):  
Greta Avancini ◽  
Andrea Guerrini ◽  
Claudia Ferroni ◽  
Daniele Tedesco ◽  
Marco Ballestri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy

scholarly journals DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells

2021 ◽  
Vol 22 (8) ◽  
pp. 4011
Author(s):  
Brianna Chen ◽  
Dylan McCuaig-Walton ◽  
Sean Tan ◽  
Andrew P. Montgomery ◽  
Bryan W. Day ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Critical Role ◽  
Stem Cell Differentiation ◽  
Neural Progenitor Cell ◽  
Cellular Heterogeneity ◽  
Differentiation Potential ◽  
Glioblastoma Stem Cells ◽  
Glioblastoma Stem Cell

Glioblastoma display vast cellular heterogeneity, with glioblastoma stem cells (GSCs) at the apex. The critical role of GSCs in tumour growth and resistance to therapy highlights the need to delineate mechanisms that control stemness and differentiation potential of GSC. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) regulates neural progenitor cell differentiation, but its role in cancer stem cell differentiation is largely unknown. Herein, we demonstrate that DYRK1A kinase is crucial for the differentiation commitment of glioblastoma stem cells. DYRK1A inhibition insulates the self-renewing population of GSCs from potent differentiation-inducing signals. Mechanistically, we show that DYRK1A promotes differentiation and limits stemness acquisition via deactivation of CDK5, an unconventional kinase recently described as an oncogene. DYRK1A-dependent inactivation of CDK5 results in decreased expression of the stemness gene SOX2 and promotes the commitment of GSC to differentiate. Our investigations of the novel DYRK1A-CDK5-SOX2 pathway provide further insights into the mechanisms underlying glioblastoma stem cell maintenance.

MerTK activity is not necessary for the proliferation of glioblastoma stem cells

2021 ◽  
Vol 186 ◽  
pp. 114437
Author(s):  
Monira Hoque ◽  
Siu Wai Wong ◽  
Ariadna Recasens ◽  
Ramzi Abbassi ◽  
Nghi Nguyen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioblastoma Stem Cells
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