Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina (Conference Presentation)

Author(s):  
Weiye Song ◽  
Libo Zhou ◽  
Ji Yi
1994 ◽  
Vol 173-174 ◽  
pp. 203-208
Author(s):  
B.H. Bairamov ◽  
I.P. Ipatova ◽  
G. Irmer ◽  
J. Monecke ◽  
V.K. Negoduyko ◽  
...  

2021 ◽  
Author(s):  
Timothy Wan Hei Luk

Optical coherence tomography (OCT) is an imaging modality that uses near infrared light interferometry for non-invasive, near-histological resolution imaging at the micron level. Concepts from dynamic light scattering (DLS) can be adapted to OCT to detect and measure the motions in the target tissue. Tissue dynamics can be observed by measuring the speckle decorrelation time (DT) of the tissue. DT analysis was performed in a preclinical study to demonstrate the repeatability and feasibility of using DLS-OCT to observe mouse tumours undergoing cisplatin treatment over a 48-hour period. Differences in the average DT data were observed for control and cisplatin-injected mice. Image segmentation based on DT values was also performed to subtract the DT contributions of pixels at blood vessel locations, resulting in the improvement of average DT calculations of the tumour tissue. The results presented are a preliminary step to analyzing and monitoring tumour growth and treatment response in vivo.


2021 ◽  
Author(s):  
Timothy Wan Hei Luk

Optical coherence tomography (OCT) is an imaging modality that uses near infrared light interferometry for non-invasive, near-histological resolution imaging at the micron level. Concepts from dynamic light scattering (DLS) can be adapted to OCT to detect and measure the motions in the target tissue. Tissue dynamics can be observed by measuring the speckle decorrelation time (DT) of the tissue. DT analysis was performed in a preclinical study to demonstrate the repeatability and feasibility of using DLS-OCT to observe mouse tumours undergoing cisplatin treatment over a 48-hour period. Differences in the average DT data were observed for control and cisplatin-injected mice. Image segmentation based on DT values was also performed to subtract the DT contributions of pixels at blood vessel locations, resulting in the improvement of average DT calculations of the tumour tissue. The results presented are a preliminary step to analyzing and monitoring tumour growth and treatment response in vivo.


2021 ◽  
Vol 127 (4) ◽  
Author(s):  
S. Skruszewicz ◽  
S. Fuchs ◽  
J. J. Abel ◽  
J. Nathanael ◽  
J. Reinhard ◽  
...  

AbstractWe present an overview of recent results on optical coherence tomography with the use of extreme ultraviolet and soft X-ray radiation (XCT). XCT is a cross-sectional imaging method that has emerged as a derivative of optical coherence tomography (OCT). In contrast to OCT, which typically uses near-infrared light, XCT utilizes broad bandwidth extreme ultraviolet (XUV) and soft X-ray (SXR) radiation (Fuchs et al in Sci Rep 6:20658, 2016). As in OCT, XCT’s axial resolution only scales with the coherence length of the light source. Thus, an axial resolution down to the nanometer range can be achieved. This is an improvement of up to three orders of magnitude in comparison to OCT. XCT measures the reflected spectrum in a common-path interferometric setup to retrieve the axial structure of nanometer-sized samples. The technique has been demonstrated with broad bandwidth XUV/SXR radiation from synchrotron facilities and recently with compact laboratory-based laser-driven sources. Axial resolutions down to 2.2 nm have been achieved experimentally. XCT has potential applications in three-dimensional imaging of silicon-based semiconductors, lithography masks, and layered structures like XUV mirrors and solar cells.


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