Real-time guidance of radiofrequency ablation catheter contact orientation with cardiac tissue using optical coherence tomography (Conference Presentation)

2019 ◽  
Author(s):  
Xin Yu ◽  
Rajinder P. Singh-Moon ◽  
Christine P. Hendon
Keyword(s):  
Optical Coherence Tomography ◽  
Radiofrequency Ablation ◽  
Real Time ◽  
Cardiac Tissue ◽  
Optical Coherence ◽  
Ablation Catheter ◽  
Contact Orientation

scholarly journals Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaowei Zhao ◽  
Ohad Ziv ◽  
Reza Mohammadpour ◽  
Benjamin Crosby ◽  
Walter J. Hoyt ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Radiofrequency Ablation ◽  
Left Atrium ◽  
Real Time ◽  
Wall Thickness ◽  
Ex Vivo ◽  
Optical Coherence ◽  
Percutaneous Radiofrequency Ablation ◽  
Cardiac Wall

AbstractRadiofrequency ablation (RFA) is commonly used to treat atrial fibrillation (AF). However, the outcome is often compromised due to the lack of direct real-time feedback to assess lesion transmurality. In this work, we evaluated the ability of polarization-sensitive optical coherence tomography (PSOCT) to measure cardiac wall thickness and assess RF lesion transmurality during left atrium (LA) RFA procedures. Quantitative transmural lesion criteria using PSOCT images were determined ex vivo using an integrated PSOCT-RFA catheter and fresh swine hearts. LA wall thickness of living swine was measured with PSOCT and validated with a micrometer after harvesting the heart. A total of 38 point lesions were created in the LA of 5 living swine with the integrated PSOCT-RFA catheter using standard clinical RFA procedures. For all lesions with analyzable PSOCT images, lesion transmurality was assessed with a sensitivity of 89% (17 of 19 tested positive) and a specificity of 100% (5 of 5 tested negative) using the quantitative transmural criteria. This is the first report of using PSOCT to assess LA RFA lesion transmurality in vivo. The results indicate that PSOCT may potentially provide direct real-time feedback for LA wall thickness and lesion transmurality.

scholarly journals Multi-center clinical study using optical coherence tomography for evaluation of cervical lesions in-vivo

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chenchen Ren ◽  
Xianxu Zeng ◽  
Zhongna Shi ◽  
Chunyan Wang ◽  
Huifen Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Real Time ◽  
Precancerous Lesions ◽  
Diagnostic Value ◽  
Optical Coherence ◽  
Cervical Lesions ◽  
In Vivo Evaluation ◽  
Histological Sections ◽  
Histological Images

AbstractIn this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. 733 patients from 5 Chinese hospitals were inspected with OCT and colposcopy-directed biopsy. The OCT images were compared with the histological sections to find out the characteristics of various categories of lesions. The OCT images were also interpreted by 3 investigators to make a 2-class classification, and the results were compared against the pathological results. Various structures of the cervical tissue were clearly observed in OCT images, which matched well with the corresponding histological sections. The OCT diagnosis results delivered a sensitivity of 87.0% (95% confidence interval, CI 82.2–90.7%), a specificity of 84.1% (95% CI 80.3–87.2%), and an overall accuracy of 85.1%. Both good consistency of OCT images and histological images and satisfactory diagnosis results were provided by OCT. Due to its features of non-invasion, real-time, and accuracy, OCT is valuable for the in-vivo evaluation of cervical lesions and has the potential to be one of the routine cervical diagnosis methods.

scholarly journals Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit

2012 ◽  
Vol 3 (7) ◽  
pp. 1557 ◽  
Author(s):  
Kenneth K. C. Lee ◽  
Adrian Mariampillai ◽  
Joe X. Z. Yu ◽  
David W. Cadotte ◽  
Brian C. Wilson ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Real Time ◽  
Graphics Processing Unit ◽  
Processing Unit ◽  
Optical Coherence ◽  
Swept Source ◽  
Graphics Processing

Real-time lesion assessment using a novel combined ultrasound and radiofrequency ablation catheter

Heart Rhythm ◽  
2011 ◽  
Vol 8 (2) ◽  
pp. 304-312 ◽  
Author(s):  
Matthew Wright ◽  
Erik Harks ◽  
Szabolcs Deladi ◽  
Freek Suijver ◽  
Maya Barley ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Real Time ◽  
Ablation Catheter
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