Evaluation of anti-inflammatory, antioxidant activity and protective effect on ulcerative colitis of traditional Chinese medicine Lian-ai jian

2019 ◽  
Author(s):  
Fan Shi ◽  
Zi-cong Wu ◽  
Zhen-ling Zhao ◽  
Tong-sheng Chen ◽  
Yi-fei Wang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Antioxidant Activity ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Protective Effect ◽  
Anti Inflammatory

scholarly journals Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xingjiang Hu ◽  
Nana Xu ◽  
Xi Yang ◽  
Xi Hu ◽  
Yunliang Zheng ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Inflammatory Response ◽  
Therapeutic Effect ◽  
Antioxidant Activities ◽  
Intestinal Flora ◽  
Signs And Symptoms ◽  
Microbial Composition ◽  
Bacterial Genus

Abstract Nigella A, also named Sieboldianoside A, has been extracted from many kinds of Traditional Chinese Medicine (TCM), such as Nigella glandulifera, Stauntonia chinensis DC., and the leaves of Acanthopanax sieboldianus. Nigella A exhibited potential analgesic, anti-inflammatory, anti-tumor, and antioxidant activities. However, whether Nigella A could treat ulcerative colitis (UC) is still unknown. As saponins always be regarded as the kinds of ingredients that could regulate immunity and intestinal flora. This research aimed to investigate the therapeutic effect of Nigella A on UC and explore its effect on intestinal flora. We noted that Nigella A and Sulfasalazine (SASP) could significantly improve the signs and symptoms, alleviate colonic pathological injury in DSS-induced mice. The changing of many specific bacterial genus such as Lactobacillus, Porphyromonadaceae, Bacteroides and Escherichia might closely related to the recovery of intestinal inflammatory response. This study initially confirmed the therapeutic effect of Nigella A and SASP on DSS-induced colitis by improving the diversity of intestinal microbial composition. Nigella A has the potential to be developed for the treatment of UC and other disorders related to the imbalance of intestinal flora.

scholarly journals Compound Traditional Chinese Medicine Dermatitis Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules in AD

2021 ◽  
Author(s):  
Rongrong Zhang ◽  
Shuai Shao ◽  
Yingxin Shen ◽  
Jiaming Sun ◽  
Songlan Piao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Inflammatory Responses ◽  
Dependent Manner ◽  
Inflammatory Skin Disease ◽  
Fingerprint Analysis ◽  
Hplc Fingerprint ◽  
Effective Components ◽  
Anti Inflammatory ◽  
Dose Dependent

Abstract Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by an itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) is a traditional classics aimed at AD composed of a mixture of extracts from five plants known to have anti-inflammatory and antiallergic effects. Materials and methods: In this study, we used HPLC and LC/MS to analyze the effective components of CTCMDO in detail and establish its HPLC fingerprint analysis. On this basis, this article studied the anti-inflammatory and antipruritic activities of CTCMDO in the treatment of DNCB-induced AD in mice.Results: Through comparison with literature data, a total of 43 compounds were identified, including phenylpropionic acid compounds; alkaloid compounds; curcumin compounds and lignans. On this basis, a fingerprint with 17 common peaks was established. In AD-like mice, CTCMDO treatment suppressed the scratching behavior induced by DNCB in a dose-dependent manner and inhibited the production of Th1/2 cytokines in serum. CTCMDO treatment reversed the up regulation of P substance levels of itch-related genes in the skin. Furthermore, CTCMDO suppressed the phosphorylation of JNK、ERK and p38 in the skin. Conclusion: In all, our work indicated that CTCMDO can signifificantly attenuate the pathological alterations of Th1/2 cytokines and itch-related mediators, and inhibit the phosphorylation of MAPKs to treat AD.

A Literature Review on Indigowoad Root Hydrogel Development for Skincare

2021 ◽  
Vol 14 (1) ◽  
pp. 95-98
Author(s):  
Siukan Law ◽  
Chuiman Lo ◽  
Jie Han ◽  
Albert Wingnang Leung ◽  
Chuanshan Xu
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Literature Review ◽  
Surface Area ◽  
Large Surface Area ◽  
The Future ◽  
Yin Yang ◽  
Anti Inflammatory

Indigowoad Root is traditional Chinese medicine. It belongs to the “cool blood herb” category which has been used for anti-inflammatory and anti-infections situations regarding the Yin-Yang theory. Hydrogel is one of the biomaterials for drug delivery that provided a large surface area and permeability, enhanced the characteristics of solubility and absorption of traditional Chinese medicine, for example, curcumin. Based on the pieces of evidence, these might have some possible methods for the synthesis of Indigowoad Root hydrogel on skincare in the future.

Retracted Article: A self-assembled supramolecular natural product gel from liquidambaric acid in traditional Chinese medicine with inherent anti-inflammatory activity for drug delivery

2020 ◽  
Vol 8 (4) ◽  
pp. 715-726 ◽  
Author(s):  
Kangkang Zhi ◽  
Jiacheng Wang
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Natural Product ◽  
Inflammatory Activity ◽  
Retracted Article ◽  
Anti Inflammatory ◽  
Self Assembled

A supramolecular self-assembled natural product gel from liquidambaric acid in traditional Chinese medicine with inherent anti-inflammatory activity for drug delivery was constructed.

scholarly journals Pharmacological Uses and Health Benefits of Ginger (Zingiber officinale) in Traditional Asian and Ancient Chinese Medicine, and Modern Practice

2019 ◽  
Vol 11 (3) ◽  
pp. 309-319
Author(s):  
Mohamad Hesam SHAHRAJABIAN ◽  
Wenli SUN ◽  
Qi CHENG
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Soft Drink ◽  
Zingiber Officinale ◽  
Modern China ◽  
Ginger Extract ◽  
Nutritional Values ◽  
Anti Oxidant ◽  
Pharmaceutical Industries ◽  
Anti Inflammatory

Ginger (Zingiber officinale) has been used as a spice and a medicine for over 200 years in traditional Chinese medicine. Ginger is an important plant with several medicinal and nutritional values used in Asian and Chinese tradition medicine. Ginger and its general compounds such as Fe, Mg, Ca, vitamin C, flavonoids, phenolic compounds (gingerdiol, gingerol, gingerdione and shogaols), sesquiterpenes, paradols has long been used as an herbal medicine to treat various symptoms including vomiting, pain, cold symptoms and it has been shown to have anti-inflammatory, anti-apoptotic, anti-tumor activities, anti-pyretic, anti-platelet, anti-tumourigenic, anti-hyperglycaemic, antioxidant anti-diabetic, anti-clotting and analgesic properties, cardiotonic, cytotoxic. It has been widely used for arthritis, cramps, sprains, sore throats, rheumatism, muscular aches, pains, vomiting, constipation, indigestion, hypertension, dementia, fever and infectious diseases. Ginger leaves have also been used for food flavouring and Asian traditional medicine especially in China. Ginger oil also used as food flavouring agent in soft drink, as spices in bakery products, in confectionary items, pickles, sauces and as a preservatives. Ginger is available in three forms, namely fresh root ginger, preserved ginger and dried ginger. The pharmacological activities of ginger were mainly attributed to its active phytocompounds 6-gingerol, 6-shogaol, zingerone beside other phenolics and flavonoids. Gingerol and shogaol in particular, is known to have anti-oxidant and anti-inflammatory properties. In both traditional Chinese medicine, and modern China, Ginger is used in about half of all herbal prescriptions. Traditional medicinal plants are often cheaper, locally available and easily consumable raw and as simple medicinal preparations. The obtained findings suggest potential of ginger extract as an additive in the food and pharmaceutical industries.

scholarly journals Clinical evaluation of traditional Chinese medicine on mild active ulcerative colitis

Medicine ◽  
2020 ◽  
Vol 99 (35) ◽  
pp. e21903
Author(s):  
Fu-Shun Kou ◽  
Lei Shi ◽  
Jun-Xiang Li ◽  
Zhi-Bin Wang ◽  
Rui Shi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Evaluation ◽  
Active Ulcerative Colitis
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