Detecting the efficacy of endotracheal tube suctioning in intubated ICU patients using in vivo catheter-based OCT (Conference Presentation)

2019 ◽  
Author(s):  
Roshan Dsouza ◽  
Darold R. Spillman ◽  
Ronit Barkalifa ◽  
Guillermo L. Monroy ◽  
Eric J. Chaney ◽  
...  
Keyword(s):  
Endotracheal Tube ◽  
Icu Patients

scholarly journals Real-Time Optical Monitoring of Endotracheal Tube Displacement

Biosensors ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 174
Author(s):  
Ramzan Ullah ◽  
Karl Doerfer ◽  
Pawjai Khampang ◽  
Faraneh Fathi ◽  
Wenzhou Hong ◽  
...  
Keyword(s):  
Endotracheal Tube ◽  
Real Time ◽  
Near Infrared ◽  
Ex Vivo ◽  
Light Emitting Diode ◽  
Clinical Care ◽  
Cost Effective ◽  
Infrared Light ◽  
In Vivo Experiments

Proper ventilation of a patient with an endotracheal tube (ETT) requires proper placement of the ETT. We present a sensitive, noninvasive, operator-free, and cost-effective optical sensor, called Opt-ETT, for the real-time assessment of ETT placement and alerting of the clinical care team should the ETT become displaced. The Opt-ETT uses a side-firing optical fiber, a near-infrared light-emitting diode, two photodetectors with an integrated amplifier, an Arduino board, and a computer loaded with a custom LabVIEW program to monitor the position of the endotracheal tube inside the windpipe. The Opt-ETT generates a visual and audible warning if the tube moves over a distance set by the operator. Displacement prediction is made using a second-order polynomial fit to the voltages measured from each detector. The system is tested on ex vivo porcine tissues, and the accuracy is determined to be better than 1.0 mm. In vivo experiments with a pig are conducted to test the performance and usability of the system.

Endotracheal tube cuffs filled with lidocaine as a drug delivery system: in vitro and in vivo investigations

2001 ◽  
Vol 13 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Gilles Dollo ◽  
Jean-Pierre Estebe ◽  
Pascal Le Corre ◽  
François Chevanne ◽  
Claude Ecoffey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Endotracheal Tube ◽  
Drug Delivery System ◽  
Delivery System

Antibacterial Properties and Application of Nanosilver Material in the Tracheal Tube

2020 ◽  
Vol 20 (10) ◽  
pp. 6542-6546
Author(s):  
Yunjie Hu ◽  
Xiaobei Ji ◽  
Dunshuang Wei ◽  
Jun Deng
Keyword(s):  
Endotracheal Tube ◽  
Endotracheal Intubation ◽  
Tracheal Tube ◽  
Antibacterial Properties ◽  
Plate Count ◽  
Control Group ◽  
Significant Difference ◽  
New Type ◽  
Experimental Group

To investigate the antibacterial ability of a new type of antibacterial tracheal tube coated with nanosilver/polyurethane in rats. In January 2016, 48 male SD rats of SPF grade, provided by the medical center of Hong Kong University of science and technology, Peking University, Shenzhen, were selected as the study objects. Twenty-four healthy rats, who underwent endotracheal intubation and retained nanosilver/polyurethane-coated new antibacterial endotracheal tube in vivo, were randomly selected as the experimental group, while 24 healthy rats who underwent endotracheal intubation at the same time and retained common endotracheal tube in vivo were randomly selected as the control group. At 12, 24, 48, and 72 hours after the operation, the number of colonies in the alveolar lavage fluid of the two groups was measured using the plate count method, and the thickness of the biofilm formed by the built-in catheter of the two groups was observed by microscope. Twelve hours after operation, there was no significant difference between the two groups (P <0.05). The colony number in BALF in the experimental group was significantly lower than that in the control group (P < 0.05). At 12 and 24 hours after operation, there was no significant difference in the biofilm thickness between the two groups (P > 0.05). In the experimental group, the thickness of biofilm that had formed by catheterization 48 and 72 hours after operation was significantly lower than that in the control group (P < 0.05). The new type of antibacterial tracheal tube, coated with nanosilver/polyurethane, has stronger antibacterial and anti-biofilm proliferation performance than that of the common tracheal tube.

Aspects of in vivo endotracheal tube intracuff pressure in cats

2019 ◽  
Vol 46 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Alice R. Bird ◽  
David J. Bird ◽  
Matthew W. McMillan
Keyword(s):  
Endotracheal Tube ◽  
Intracuff Pressure

Influence of site of tracheal pressure measurement on in situ estimation of endotracheal tube resistance

1994 ◽  
Vol 77 (6) ◽  
pp. 2899-2906 ◽  
Author(s):  
P. Navalesi ◽  
P. Hernandez ◽  
D. Laporta ◽  
J. S. Landry ◽  
F. Maltais ◽  
...  
Keyword(s):  
Endotracheal Tube ◽  
Fluid Dynamic ◽  
Reference Value ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Tracheal Pressure

In situ measurement of distal tracheal pressure (Ptr) via an intraluminal side-hole catheter (IC) has been used to determine endotracheal tube (Rett) and intrinsic patient (Rpt) resistances in intubated subjects. Because of differences in cross-sectional area between the endotracheal tube (ETT) and trachea, fluid dynamic principles predict that IC position should critically influence these results. Accordingly, the aim of this study was to determine the effect of IC position on Rett. Ptr was recorded in vitro through an IC from 2 cm inside, at the tip of, or 2 cm outside an ETT (7, 8, and 9 mm ID) situated within an artificial trachea (13, 18, and 22 mm ID). A reference value of Rett was also obtained. Results were unaffected by IC position during inspiration, overestimating Rett by 7.9 +/- 0.7% (SE). In contrast, during expiration, Rett fell as IC position changed from outside to inside the ETT and was underestimated by 41.3 +/- 3.6% with Ptr recorded inside the ETT. Varying ETT or tracheal size had little effect on the relative error in Rett. The IC itself did increase Rett due to a reduction in effective cross-sectional area, the change varying directly with IC size and inversely with ETT caliber. In vivo values in 11 intubated patients were comparable to in vitro results. In summary, IC position and size can have important consequences on in situ measurements of Ptr and should be considered when clinically monitoring Rett or Rpt.

scholarly journals Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

2020 ◽  
Vol 222 (11) ◽  
pp. 1789-1793 ◽  
Author(s):  
Christophe Guervilly ◽  
Stephane Burtey ◽  
Florence Sabatier ◽  
Raphaël Cauchois ◽  
Guillaume Lano ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Intensive Care ◽  
Retrospective Study ◽  
Disease Severity ◽  
Inflammatory Cytokines ◽  
Endothelial Injury ◽  
Circulating Endothelial Cells ◽  
Vascular Events ◽  
Icu Patients

Abstract Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.

scholarly journals Penetration of Ertapenem into Muscle Measured by In Vivo Microdialysis in Mechanically Ventilated Patients

2011 ◽  
Vol 55 (7) ◽  
pp. 3573-3575 ◽  
Author(s):  
I. Boyadjiev ◽  
A. Boulamery ◽  
N. Simon ◽  
C. Martin ◽  
B. Bruguerolle ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Large Population ◽  
In Vivo Microdialysis ◽  
Icu Patients ◽  
Once Daily ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Kinetics Of ◽  
Ventilated Patients

ABSTRACTErtapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem concentrations were above the MIC values of targeted pathogens. In a few patients, the concentrations were below the MIC values. The clinical efficiency of ertapenem at 1 g once daily should be evaluated in a large population of ICU patients.

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