High-resolution micro-OCT for endothelial cell visualization in the coronary arteries (Conference Presentation)

2019 ◽  
Author(s):  
Kensuke Nishimiya ◽  
Osman O. Ahsen ◽  
Biwei Yin ◽  
Zhonglie Piao ◽  
Jiheun Ryu ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Resolution ◽  
Coronary Arteries

SUPER HIGH RESOLUTION µOCT FOR ENDOTHELIAL CELL VISUALIZATION IN THE CORONARY ARTERIES EX VIVO

2018 ◽  
Vol 71 (11) ◽  
pp. A1350
Author(s):  
Kensuke Nishimiya ◽  
Biwei Yin ◽  
Zhonglie Piao ◽  
Gargi Sharma ◽  
Hany Osman ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Resolution ◽  
Coronary Arteries ◽  
Ex Vivo

scholarly journals P2271Super high-resolution OCT for endothelial cell visualization in the coronary arteries

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
K Nishimiya ◽  
B Yin ◽  
Z Piao ◽  
H Osman ◽  
J Ryu ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Resolution ◽  
Coronary Arteries ◽  
High Resolution Oct

scholarly journals Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging

2021 ◽  
Vol 9 ◽  
Author(s):  
Fei Ge ◽  
Qi Pan ◽  
Yue Qin ◽  
Mengping Jia ◽  
Chengchao Ruan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Endothelial Cell ◽  
Single Cell ◽  
Coronary Arteries ◽  
Cell Senescence ◽  
Open Chromatin ◽  
Vegf Receptor ◽  
Aged Mouse ◽  
Vascular Aging ◽  
Master Regulator

Vascular aging is a potent driver of cardiovascular and cerebrovascular diseases. Vascular aging features cellular and functional changes, while its molecular mechanisms and the cell heterogeneity are poorly understood. This study aims to 1) explore the cellular and molecular properties of aged cardiac vasculature in monkey and mouse and 2) demonstrate the role of transcription factor BACH1 in the regulation of endothelial cell (EC) senescence and its mechanisms. Here we analyzed published single-cell RNA sequencing (scRNA-seq) data from monkey coronary arteries and aortic arches and mouse hearts. We revealed that the gene expression of YAP1, insulin receptor, and VEGF receptor 2 was downregulated in both aged ECs of coronary arteries’ of monkey and aged cardiac capillary ECs of mouse, and proliferation-related cardiac capillary ECs were significantly decreased in aged mouse. Increased interaction of ECs and immunocytes was observed in aged vasculature of both monkey and mouse. Gene regulatory network analysis identified BACH1 as a master regulator of aging-related genes in both coronary and aorta ECs of monkey and cardiac ECs of mouse. The expression of BACH1 was upregulated in aged cardiac ECs and aortas of mouse. BACH1 aggravated endothelial cell senescence under oxidative stress. Mechanistically, BACH1 occupied at regions of open chromatin and bound to CDKN1A (encoding for P21) gene enhancers, activating its transcription in senescent human umbilical vein endothelial cells (HUVECs). Thus, these findings demonstrate that BACH1 plays an important role in endothelial cell senescence and vascular aging.

Hybrid imaging: combination of PET, SPECT, CT, and MRI

2015 ◽  
pp. 89-98
Author(s):  
Juhani Knuuti ◽  
Philipp A. Kaufmann
Keyword(s):  
High Resolution ◽  
Coronary Arteries ◽  
Systolic Function ◽  
Nuclear Imaging ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Functional Evaluation ◽  
Functional Information ◽  
Almost All ◽  
Ct And Mri

Hybrid scanners combining PET or SPECT with high resolution multi-detector CT are becoming the standard for almost all commercially available nuclear imaging systems. In addition, the newest generation of scanners offers combination of PET with MRI. Hybrid scanners offer the ability to assess the anatomy of the heart and coronary arteries, and the functional evaluation either at stress (for assessment of induced ischaemia), or at rest (for viability) in association with the left ventricular systolic function. Therefore, combining functional information with anatomy by using hybrid systems is appealing.

Non‐invasive imaging of coronary arteries in living mice using high‐resolution echocardiography

2004 ◽  
Vol 38 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Li‐ming Gan ◽  
Johannes Wikström ◽  
Göran Bergström ◽  
Birger Wandt
Keyword(s):  
High Resolution ◽  
Coronary Arteries ◽  
Non Invasive

scholarly journals High-Resolution Late Gadolinium Enhancement Magnetic Resonance for the Diagnosis of Myocardial Infarction With Nonobstructed Coronary Arteries

2020 ◽  
Vol 13 (5) ◽  
pp. 1135-1148 ◽  
Author(s):  
Pierre-Francois Lintingre ◽  
Hubert Nivet ◽  
Stéphanie Clément-Guinaudeau ◽  
Claudia Camaioni ◽  
Soumaya Sridi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Late Gadolinium Enhancement ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Coronary Arteries ◽  
Gadolinium Enhancement

High-resolution coronary MR angiography for evaluation of patients with anomalous coronary arteries: visualization of the intramural segment

2015 ◽  
Vol 45 (8) ◽  
pp. 1146-1152 ◽  
Author(s):  
David M. Biko ◽  
Claudia Chung ◽  
David M. Hitt ◽  
Gregory Kurio ◽  
Olaf Reinhartz ◽  
...  
Keyword(s):  
High Resolution ◽  
Coronary Arteries ◽  
Mr Angiography ◽  
Anomalous Coronary ◽  
Anomalous Coronary Arteries ◽  
Coronary Mr Angiography

scholarly journals Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.

1988 ◽  
Vol 63 (5) ◽  
pp. 903-910 ◽  
Author(s):  
R A Cohen ◽  
K M Zitnay ◽  
C C Haudenschild ◽  
L D Cunningham
Keyword(s):  
Endothelial Cell ◽  
Coronary Arteries ◽  
Pig Coronary Arteries
Sign in / Sign up

Export Citation Format

Share Document