In vivo measurement of retinal neurovascular changes with transcorneal electrical stimulation using optical coherence tomography

2018 ◽  
Author(s):  
Chuanqing Zhou ◽  
Hao Zheng ◽  
Qian Li ◽  
Peng Cheng Sun
Keyword(s):  
Optical Coherence Tomography ◽  
Electrical Stimulation ◽  
Optical Coherence ◽  
Transcorneal Electrical Stimulation ◽  
In Vivo Measurement

scholarly journals Retinal neurovascular responses to transcorneal electrical stimulation measured with optical coherence tomography

2020 ◽  
Vol 245 (4) ◽  
pp. 289-300 ◽  
Author(s):  
Xiaofan Su ◽  
Hao Zheng ◽  
Qian Li ◽  
Pengcheng Sun ◽  
Meixuan Zhou ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Electrical Stimulation ◽  
Optical Coherence ◽  
Neural Responses ◽  
Neuroprotective Effects ◽  
Vascular Responses ◽  
Transcorneal Electrical Stimulation ◽  
Optic Nerve Diseases ◽  
Sd Oct

Noninvasive transcorneal electrical stimulation (TES) has emerged as a potential strategy to facilitate visual restoration and promote retinal cell survival for certain retinal and optic nerve diseases owing to its neuroprotective effects. However, the neurovascular responses of retinal neurons evoked by TES have not been completely determined. To investigate this issue, we utilized a custom-designed spectral-domain optical coherence tomography (SD-OCT) to record the retinal neural and vascular responses under TES in vivo simultaneously. Significant increases of both positive and negative intrinsic optical signal (IOS) changes were recorded in all three segmented retinal layers, which mainly related to neural activities. However, the changes of TES-induced retinal vascular responses, including blood velocity, cross-sectional area of vessel, and blood flow, were not significant. It suggests that TES mainly elicited neural responses in retina, while no significant vascular responses were evoked. Our results provide experimental evidence to the mechanism of retinal neurovascular coupling under TES. Additionally, the present study also suggests that SD-OCT could be utilized as a promoting method to explore neurovascular responses under retinal stimulation in clinical treatment and technology. Impact statement Noninvasive transcorneal electrical stimulation (TES) has emerged as an effective treatment for certain retinal and optic nerve diseases owing to its neuroprotective effects. However, the retinal neurovascular responses evoked by TES have not been completely determined. To investigate this issue, we utilized a custom-designed spectral-domain optical coherence tomography (SD-OCT) to record the retinal neural and vascular responses evoked by TES in vivo simultaneously. The present study suggested that TES mainly elicited neural responses in retina, while no significant vascular responses were evoked. Our results provide experimental evidence to the mechanism of retinal neurovascular coupling evoked by TES. Additionally, the present study also suggests that SD-OCT could be utilized as a promoting method to explore neurovascular responses under retinal electrical stimulation.

scholarly journals Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa

2020 ◽  
Author(s):  
Olga Zabek ◽  
Hanna Camenzind Zuche ◽  
Ursula Müller ◽  
Hendrik P. N. Scholl ◽  
Annekatrin Rickmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Electrical Stimulation ◽  
Retinitis Pigmentosa ◽  
Optical Coherence Tomography Angiography ◽  
Statistical Significance ◽  
Vascular Density ◽  
Optical Coherence ◽  
Transcorneal Electrical Stimulation ◽  
Retinal Layers ◽  
Perfusion Density

Abstract Purpose Transcorneal electrical stimulation (TES) is a novel treatment approach for patients with retinitis pigmentosa (RP). The aim of our study was to observe changes in optical coherence tomography angiography (OCTA) that would be attributed to TES treatment. Methods A total of 73 eyes were included: 43 eyes of 22 subjects (11 ♀, 11 ♂) suffering from RP were examined at baseline (BL), after first stimulation (TS), 1 week (1W), and 6 months (6M) after treatment initiation and were compared with 30 control eyes of 15 subjects (8 ♀, 7 ♂). TES was performed simultaneously on both eyes for 30 min weekly. OCTA scans of 9 × 15 mm were recorded with a PLEX Elite 9000 swept-source OCTA device (Carl Zeiss Meditec AG, Jena). Vascular density metrics such as perfusion density (PD) and vessel density (VD) were calculated automatically for the macular area by using standardised extended early treatment diabetic retinopathy study (ETDRS) grids centred around the fovea. In addition, the capillary perfusion density (CPD) and the capillary flux index (CFI) of the peripapillary nerve fibre layer microvasculature in all four quadrants of an annulus centred at the optic disc were measured. All parameters were determined over all retinal layers and separately for the superficial (SCP) and deep capillary plexus (DCP). ANOVA-based linear mixed-effects models were calculated with SPSS®. Results Throughout the course of TES treatment, the macular VD and PD of all retinal layers in all subsections showed a slight decrement without reaching statistical significance, also when analysed separately in the SCP and DCP (p > 0.08). In analogy, the average CPD and CFI also presented with a slight decrement (p > 0.20). However, when compared with controls, most OCTA parameters showed a significant decrement (p < 0.05). When analysed systematically in all subsections of the extended ETDRS grid, the temporal macular subsections within the outer ring (radius 1.5–3 mm) and also of the peripheral C1, C2, and C3 rings (radius 3–7.5 mm) showed lower VD and PD values when compared with the other subsections (p < 0.05). Conclusion Vascular density metrics in the macular region and the peripapillary microvasculature appear to remain unaffected by continuous TES treatment within a period of 6 months.

In vivo measurement of amplifying motion within the organ of Corti under sound stimulation using optical coherence tomography

2012 ◽  
Author(s):  
Niloy Choudhury ◽  
Fangyi Chen ◽  
Dingjun Zha ◽  
Anders Fridberger ◽  
Jiefu Zheng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Organ Of Corti ◽  
Optical Coherence ◽  
Sound Stimulation ◽  
In Vivo Measurement

In vivo measurement of retinal physiology with high-speed ultrahigh-resolution optical coherence tomography

2006 ◽  
Vol 31 (15) ◽  
pp. 2308 ◽  
Author(s):  
V. J. Srinivasan ◽  
M. Wojtkowski ◽  
J. G. Fujimoto ◽  
J. S. Duker
Keyword(s):  
Optical Coherence Tomography ◽  
High Speed ◽  
Optical Coherence ◽  
Ultrahigh Resolution ◽  
In Vivo Measurement
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