scholarly journals High level adaptive optics supervision software for fast transition to optimal performance

2018 ◽  
Author(s):  
Visa A. Korkiakoski ◽  
François Rigaut ◽  
Ian Price ◽  
Doris Grosse ◽  
Michael Copeland ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
Optimal Performance ◽  
High Level

scholarly journals How to Use Linear Programming for Information System Performances Optimization

2014 ◽  
Vol 5 (3) ◽  
pp. 49-66
Author(s):  
Marko Hell ◽  
Tea Dragičević
Keyword(s):  
Linear Programming ◽  
National Park ◽  
Dynamic Environment ◽  
Optimal Performance ◽  
Quantitative Methodology ◽  
Strategic Objectives ◽  
Strategic Objective ◽  
Business Goals ◽  
High Level

Abstract Background: Organisations nowadays operate in a very dynamic environment, and therefore, their ability of continuously adjusting the strategic plan to the new conditions is a must for achieving their strategic objectives. BSC is a well-known methodology for measuring performances enabling organizations to learn how well they are doing. In this paper, “BSC for IS” will be proposed in order to measure the IS impact on the achievement of organizations’ business goals. Objectives: The objective of this paper is to present the original procedure which is used to enhance the BSC methodology in planning the optimal targets of IS performances value in order to maximize the organization's effectiveness. Methods/Approach: The method used in this paper is the quantitative methodology - linear programming. In the case study, linear programming is used for optimizing organization’s strategic performance. Results: Results are shown on the example of a case study national park. An optimal performance value for the strategic objective has been calculated, as well as an optimal performance value for each DO (derived objective). Results are calculated in Excel, using Solver Add-in. Conclusions: The presentation of methodology through the case study of a national park shows that this methodology, though it requires a high level of formalisation, provides a very transparent performance calculation.

Effects of Fast, Slow, and Adaptive Amplitude Compression on Children’s and Adults’ Perception of Meaningful Acoustic Information

2014 ◽  
Vol 25 (09) ◽  
pp. 834-847 ◽  
Author(s):  
Andrea L. Pittman ◽  
Ashley J. Pederson ◽  
Madalyn A. Rash
Keyword(s):  
Optimal Performance ◽  
Speech Stimulus ◽  
Environmental Sound ◽  
Environmental Sounds ◽  
Low Level ◽  
Release Times ◽  
Compression Speed ◽  
Amplitude Compression ◽  
Adaptive Compression ◽  
High Level

Background: Fast- and slow-acting amplitude compression parameters have complementary strengths and weaknesses that limit the full benefit of this feature to hearing aid users. Adaptive time constants have been suggested in the literature as a means of optimizing the benefits of amplitude compression. Purpose: The purpose of this study was to compare the effects of three amplitude compression release times (slow, fast, and adaptive) on children’s and adults’ accuracy for categorizing speech and environmental sounds. Research Design: Participants were asked to categorize speech or environmental sounds embedded in short trials containing low-level playground noise. Stimulus trials included either a high-level environmental sound followed by a lower-level speech stimulus (word) or a high-level speech stimulus followed by a lower-level environmental sound. The listeners responded to the second (low-level) stimulus in each trial. The two stimuli overlapped temporally in half of the trials but not in the other half. The stimulus trials were processed to simulate amplitude compression having fast (40 msec), slow (800 msec), or adaptive release times. The adaptive-compression parameters operated in a slow fashion until a sudden increase/decrease in level required a rapid change in gain. Study Sample: Participants were 15 children and 26 adults with hearing loss (HL) as well as 20 children and 21 adults with normal hearing (NH). Data Collection and Analyses: Performance (in % correct) was arcsine transformed and subjected to repeated-measures analysis of variance with pairwise comparisons of significant main effects using Bonferroni adjustments for multiple comparisons. Results: Overall, the performance of listeners with HL was poorer than that of the listeners with NH and performance for the environmental sounds was poorer than for the speech stimuli, particularly for the adults and children with HL. Significant effects of age group, stimulus overlap, and compression speed were observed for the listeners with NH, whereas effects of stimulus overlap and compression speed were found for the listeners with HL. Whereas listeners with NH achieved optimal performance with slow-acting compression, the listeners with HL achieved optimal performance with adaptive compression. Conclusions: Although slow, fast, and adaptive compression affects the acoustic signal in a subtle fashion, amplitude compression significantly affects perception of speech and environmental sounds.

Transcription factor/DNA interactions visualized by electron spectroscopic imaging

1992 ◽  
Vol 50 (1) ◽  
pp. 450-451
Author(s):  
David P. Bazett-Jones ◽  
Mark L. Brown
Keyword(s):  
Transcription Factor ◽  
Dna Sequences ◽  
Transcription Initiation ◽  
Molecular Mechanisms ◽  
Phosphorus Content ◽  
Spectroscopic Imaging ◽  
Electron Spectroscopic Imaging ◽  
Dna Backbone ◽  
Two Parameters ◽  
High Level

A multisubunit RNA polymerase enzyme is ultimately responsible for transcription initiation and elongation of RNA, but recognition of the proper start site by the enzyme is regulated by general, temporal and gene-specific trans-factors interacting at promoter and enhancer DNA sequences. To understand the molecular mechanisms which precisely regulate the transcription initiation event, it is crucial to elucidate the structure of the transcription factor/DNA complexes involved. Electron spectroscopic imaging (ESI) provides the opportunity to visualize individual DNA molecules. Enhancement of DNA contrast with ESI is accomplished by imaging with electrons that have interacted with inner shell electrons of phosphorus in the DNA backbone. Phosphorus detection at this intermediately high level of resolution (≈lnm) permits selective imaging of the DNA, to determine whether the protein factors compact, bend or wrap the DNA. Simultaneously, mass analysis and phosphorus content can be measured quantitatively, using adjacent DNA or tobacco mosaic virus (TMV) as mass and phosphorus standards. These two parameters provide stoichiometric information relating the ratios of protein:DNA content.

Advances in Stem Instrumentation for Biology

1990 ◽  
Vol 48 (1) ◽  
pp. 362-363
Author(s):  
J. S. Wall
Keyword(s):  
Scanning Transmission Electron Microscope ◽  
Carbon Films ◽  
Specimen Preparation ◽  
Material Deposition ◽  
Active User ◽  
Percent Improvement ◽  
Scanning Transmission ◽  
The Moment ◽  
Film Substrate ◽  
High Level

The forte of the Scanning transmission Electron Microscope (STEM) is high resolution imaging with high contrast on thin specimens, as demonstrated by visualization of single heavy atoms. of equal importance for biology is the efficient utilization of all available signals, permitting low dose imaging of unstained single molecules such as DNA.Our work at Brookhaven has concentrated on: 1) design and construction of instruments optimized for a narrow range of biological applications and 2) use of such instruments in a very active user/collaborator program. Therefore our program is highly interactive with a strong emphasis on producing results which are interpretable with a high level of confidence.The major challenge we face at the moment is specimen preparation. The resolution of the STEM is better than 2.5 A, but measurements of resolution vs. dose level off at a resolution of 20 A at a dose of 10 el/A2 on a well-behaved biological specimen such as TMV (tobacco mosaic virus). To track down this problem we are examining all aspects of specimen preparation: purification of biological material, deposition on the thin film substrate, washing, fast freezing and freeze drying. As we attempt to improve our equipment/technique, we use image analysis of TMV internal controls included in all STEM samples as a monitor sensitive enough to detect even a few percent improvement. For delicate specimens, carbon films can be very harsh-leading to disruption of the sample. Therefore we are developing conducting polymer films as alternative substrates, as described elsewhere in these Proceedings. For specimen preparation studies, we have identified (from our user/collaborator program ) a variety of “canary” specimens, each uniquely sensitive to one particular aspect of sample preparation, so we can attempt to separate the variables involved.

A Questionnaire Survey of Current Rehabilitation Practices for Adults With Normal Hearing Sensitivity Who Experience Auditory Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 738-761
Author(s):  
Tess K. Koerner ◽  
Melissa A. Papesh ◽  
Frederick J. Gallun
Keyword(s):  
Hearing Aids ◽  
Questionnaire Survey ◽  
Patient Population ◽  
Clinical Care ◽  
Normal Hearing ◽  
Auditory Training ◽  
Training Methods ◽  
Hearing Sensitivity ◽  
Considerable Benefit ◽  
High Level

Purpose A questionnaire survey was conducted to collect information from clinical audiologists about rehabilitation options for adult patients who report significant auditory difficulties despite having normal or near-normal hearing sensitivity. This work aimed to provide more information about what audiologists are currently doing in the clinic to manage auditory difficulties in this patient population and their views on the efficacy of recommended rehabilitation methods. Method A questionnaire survey containing multiple-choice and open-ended questions was developed and disseminated online. Invitations to participate were delivered via e-mail listservs and through business cards provided at annual audiology conferences. All responses were anonymous at the time of data collection. Results Responses were collected from 209 participants. The majority of participants reported seeing at least one normal-hearing patient per month who reported significant communication difficulties. However, few respondents indicated that their location had specific protocols for the treatment of these patients. Counseling was reported as the most frequent rehabilitation method, but results revealed that audiologists across various work settings are also successfully starting to fit patients with mild-gain hearing aids. Responses indicated that patient compliance with computer-based auditory training methods was regarded as low, with patients generally preferring device-based rehabilitation options. Conclusions Results from this questionnaire survey strongly suggest that audiologists frequently see normal-hearing patients who report auditory difficulties, but that few clinicians are equipped with established protocols for diagnosis and management. While many feel that mild-gain hearing aids provide considerable benefit for these patients, very little research has been conducted to date to support the use of hearing aids or other rehabilitation options for this unique patient population. This study reveals the critical need for additional research to establish evidence-based practice guidelines that will empower clinicians to provide a high level of clinical care and effective rehabilitation strategies to these patients.

805: High-Level Cyclin D1 is Associated with High Gleason Grade and Predicts Worse Biochemical-Free Survival in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Rile Li ◽  
Hong Dai ◽  
Thomas M. Wheeler ◽  
Anna Frolov ◽  
Gustavo Ayala
Keyword(s):  
Prostate Cancer ◽  
Cyclin D1 ◽  
Gleason Grade ◽  
Free Survival ◽  
High Level
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