Optical elastography and applications in ocular biomechanics (Conference Presentation)

Transpupillary Collagen Photocrosslinking for Targeted Modulation of Ocular Biomechanics

Biomaterials ◽

10.1016/j.biomaterials.2021.120735 ◽

2021 ◽

pp. 120735

Author(s):

B.G. Gerberich ◽

B.G. Hannon ◽

A. Hejri ◽

E.J. Winger ◽

E. Schrader Echeverri ◽

...

Keyword(s):

Ocular Biomechanics

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Ocular Biomechanics in Glaucoma

Ophthalmology Research™ - Mechanisms of the Glaucomas ◽

10.1007/978-1-59745-373-8_26 ◽

2008 ◽

pp. 471-489

Author(s):

C. Ross Ethier ◽

Victor H. Barocas ◽

J. Crawford Downs

Keyword(s):

Ocular Biomechanics

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Ocular biomechanics due to ground blast reinforcement

Computer Methods and Programs in Biomedicine ◽

10.1016/j.cmpb.2021.106425 ◽

2021 ◽

Vol 211 ◽

pp. 106425

Author(s):

Alireza Karimi ◽

Reza Razaghi ◽

Christopher A. Girkin ◽

J. Crawford Downs

Keyword(s):

Ocular Biomechanics

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Ocular Biomechanics: Measurement Parameters and Terminology

Journal of Refractive Surgery ◽

10.3928/1081597x-20110519-01 ◽

2011 ◽

Vol 27 (6) ◽

pp. 396-397 ◽

Cited By ~ 10

Author(s):

Dan Z. Reinstein ◽

Marine Gobbe ◽

Timothy J. Archer

Keyword(s):

Ocular Biomechanics

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Camera-based optical palpation

Scientific Reports ◽

10.1038/s41598-020-72603-5 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Rowan W. Sanderson ◽

Qi Fang ◽

Andrea Curatolo ◽

Wayne Adams ◽

Devina D. Lakhiani ◽

...

Keyword(s):

Spatial Resolution ◽

Digital Camera ◽

Base Material ◽

Cost Effective ◽

Digital Photograph ◽

Imaging Tool ◽

Measured Strain ◽

Dense Distribution ◽

Optical Elastography ◽

The Relationship

Abstract Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach opens the possibility to greatly expand applications of optical elastography both within and beyond the field of medical imaging. Camera-based optical palpation (CBOP) utilises a digital camera to acquire photographs that quantify the light intensity transmitted through a silicone layer comprising a dense distribution of micro-pores (diameter, 30–100 µm). As the transmission of light through the micro-pores increases with compression, we deduce strain in the layer directly from intensity in the digital photograph. By pre-characterising the relationship between stress and strain of the layer, the measured strain map can be converted to an optical palpogram, a map of stress that visualises mechanical contrast in the sample. We demonstrate a spatial resolution as high as 290 µm in CBOP, comparable to that achieved using an optical coherence tomography-based implementation of optical palpation. In this paper, we describe the fabrication of the micro-porous layer and present experimental results from structured phantoms containing stiff inclusions as small as 0.5 × 0.5 × 1 mm. In each case, we demonstrate high contrast between the inclusion and the base material and validate both the contrast and spatial resolution achieved using finite element modelling. By performing CBOP on freshly excised human breast tissue, we demonstrate the capability to delineate tumour from surrounding benign tissue.

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