Resilient modular small-world directed brain networks in healthy subjects with large-scale Granger causality analysis of resting-state functional MRI

2018 ◽  
Author(s):  
Udaysankar Chockanathan ◽  
Anas Z. Abidin ◽  
Adora M. DSouza ◽  
Axel Wismüller ◽  
Giovanni Schifitto
Keyword(s):  
Granger Causality ◽  
Functional Mri ◽  
Resting State ◽  
Healthy Subjects ◽  
Large Scale ◽  
Brain Networks ◽  
Small World ◽  
Causality Analysis ◽  
Granger Causality Analysis

scholarly journals Large-scale Granger causality analysis on resting-state functional MRI

2016 ◽  
Author(s):  
Adora M. D'Souza ◽  
Anas Zainul Abidin ◽  
Lutz Leistritz ◽  
Axel Wismüller
Keyword(s):  
Granger Causality ◽  
Functional Mri ◽  
Resting State ◽  
Large Scale ◽  
Causality Analysis ◽  
Granger Causality Analysis

scholarly journals Stroke-related alterations in inter-areal communication revealed via Granger causality analysis

2021 ◽  
Author(s):  
Michele Allegra ◽  
Chiara Favaretto ◽  
Nicholas Metcalf ◽  
Maurizio Corbetta ◽  
Andrea Brovelli
Keyword(s):  
Functional Connectivity ◽  
Granger Causality ◽  
Resting State ◽  
Information Transfer ◽  
Large Scale ◽  
Functional Organization ◽  
Information Flows ◽  
Causality Analysis ◽  
Stroke Patients ◽  
Granger Causality Analysis

ABSTRACTNeuroimaging and neurological studies suggest that stroke is a brain network syndrome. While causing local ischemia and cell damage at the site of injury, stroke strongly perturbs the functional organization of brain networks at large. Critically, functional connectivity abnormalities parallel both behavioral deficits and functional recovery across different cognitive domains. However, the reasons for such relations remain poorly understood. Here, we tested the hypothesis that alterations in inter-areal communication underlie stroke-related modulations in functional connectivity (FC). To this aim, we used resting-state fMRI and Granger causality analysis to quantify information transfer between brain areas and its alteration in stroke. Two main large-scale anomalies were observed in stroke patients. First, inter-hemispheric information transfer was strongly decreased with respect to healthy controls. Second, information transfer within the affected hemisphere, and from the affected to the intact hemisphere was reduced. Both anomalies were more prominent in resting-state networks related to attention and language, and they were correlated with impaired performance in several behavioral domains. Overall, our results support the hypothesis that stroke perturbs inter-areal communication within and across hemispheres, and suggest novel therapeutic approaches aimed at restoring normal information flow.SIGNIFICANCE STATEMENTA thorough understanding of how stroke perturbs brain function is needed to improve recovery from the severe neurological syndromes affecting stroke patients. Previous resting-state neuroimaging studies suggested that interaction between hemispheres decreases after stroke, while interaction between areas of the same hemisphere increases. Here, we used Granger causality to reconstruct information flows in the brain at rest, and analyze how stroke perturbs them. We showed that stroke causes a global reduction of inter-hemispheric communication, and an imbalance between the intact and the affected hemisphere: information flows within and from the latter are impaired. Our results may inform the design of stimulation therapies to restore the functional balance lost after stroke.

Small-world directed networks in the human brain: Multivariate Granger causality analysis of resting-state fMRI

NeuroImage ◽  
2011 ◽  
Vol 54 (4) ◽  
pp. 2683-2694 ◽  
Author(s):  
Wei Liao ◽  
Jurong Ding ◽  
Daniele Marinazzo ◽  
Qiang Xu ◽  
Zhengge Wang ◽  
...  
Keyword(s):  
Human Brain ◽  
Granger Causality ◽  
Resting State ◽  
Small World ◽  
Resting State Fmri ◽  
Causality Analysis ◽  
Directed Networks ◽  
Granger Causality Analysis

scholarly journals Effective connectivity of the large-scale brain networks for procrastination: A Granger causality analysis

2019 ◽  
Vol 50 (1) ◽  
pp. 54-69
Author(s):  
ZhiYi CHEN ◽  
Ti SU ◽  
Rong ZHANG ◽  
Ting XU ◽  
Fan ZHOU ◽  
...  
Keyword(s):  
Granger Causality ◽  
Large Scale ◽  
Effective Connectivity ◽  
Brain Networks ◽  
Causality Analysis ◽  
Granger Causality Analysis

scholarly journals Multivariate Granger Causality Analysis of Acupuncture Effects in Mild Cognitive Impairment Patients: An fMRI Study

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Shangjie Chen ◽  
Lijun Bai ◽  
Maosheng Xu ◽  
Fang Wang ◽  
Liang Yin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Granger Causality ◽  
Effective Connectivity ◽  
Brain Networks ◽  
Brain Regions ◽  
Causality Analysis ◽  
Granger Causality Analysis ◽  
Cognitive States ◽  
Dorsolateral Prefrontal

Evidence from clinical reports has indicated that acupuncture has a promising effect on mild cognitive impairment (MCI). However, it is still unknown that by what way acupuncture can modulate brain networks involving the MCI. In the current study, multivariate Granger causality analysis (mGCA) was adopted to compare the interregional effective connectivity of brain networks by varying needling depths (deep acupuncture, DA; superficial acupuncture, SA) and at different cognitive states, which were the MCI and healthy control (HC). Results from DA at KI3 in MCI showed that the dorsolateral prefrontal cortex and hippocampus emerged as central hubs and had significant causal influences with each other, but significant in HC for DA. Moreover, only several brain regions had remarkable causal interactions following SA in MCI and even few brain regions following SA in HC. Our results indicated that acupuncture at KI3 at different cognitive states and with varying needling depths may induce distinct reorganizations of effective connectivities of brain networks, and DA at KI3 in MCI can induce the strongest and more extensive effective connectivities related to the therapeutic effect of acupuncture in MCI. The study demonstrated the relatively functional specificity of acupuncture at KI3 in MCI, and needling depths play an important role in acupuncture treatments.

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