Serial assessment of CT coronary calcifications for regression/progression analysis (Conference Presentation)

2018 ◽  
Author(s):  
David L. Wilson ◽  
Di Wen ◽  
Brendan Eck ◽  
Jerry Lipinski ◽  
Jacob Levi ◽  
...  
Keyword(s):  
Coronary Calcifications

scholarly journals Low Bone Volume—A Risk Factor for Coronary Calcifications in Hemodialysis Patients

2009 ◽  
Vol 4 (2) ◽  
pp. 450-455 ◽  
Author(s):  
Teresa Adragao ◽  
Johann Herberth ◽  
Marie-Claude Monier-Faugere ◽  
Adam J. Branscum ◽  
Anibal Ferreira ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hemodialysis Patients ◽  
Bone Volume ◽  
Coronary Calcifications

Low iPTH Can Predict Vascular and Coronary Calcifications in Patients Undergoing Peritoneal Dialysis

2011 ◽  
Vol 117 (2) ◽  
pp. c113-c119 ◽  
Author(s):  
Sun Chul Kim ◽  
Hye Won Kim ◽  
Se Won Oh ◽  
Ha Na Yang ◽  
Myung-Gyu Kim ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Coronary Calcifications

Coronary calcifications and plaque characteristics in patients with end-stage renal disease

2013 ◽  
Vol 24 (6) ◽  
pp. 501-508 ◽  
Author(s):  
Borut Jug ◽  
Jigar Kadakia ◽  
Mohit Gupta ◽  
Jenny Papazian ◽  
Arya Derakhshani ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Coronary Calcifications ◽  
Stage Renal Disease ◽  
End Stage

P873Plasma PCSK9 levels and atherosclerosis burden in the coronary arteries of patients undergoing coronary angiography

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y Panahi ◽  
M S Ghahrodi ◽  
M S Jamshir ◽  
M A Safarpour ◽  
M Pirro ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Coronary Arteries ◽  
Coronary Stenosis ◽  
Coronary Vessels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Vessel Disease ◽  
Coronary Calcifications ◽  
Triple Vessel Disease

Abstract Background Plasma PCSK9 levels, a novel and effective therapeutic target for CVD prevention, have been associated with CVD events irrespective of traditional risk factors. Whether PCSK9 levels predict coronary artery disease (CAD) burden and severity is a matter of dispute. Purpose To investigate the association between plasma PCSK9 levels and CAD characteristics, including number of major diseased vessels, severity of coronary stenosis, and the burden of coronary calcifications. Methods One hundred and one patients undergoing coronary angiography were recruited for this cross-sectional study. The number of major coronary diseased vessels was defined as the presence of ≥1 stenoses ≥50% in diameter of at least one major coronary artery. CAD severity was defined as either the absence of coronary stenosis (no-CAD), CAD<50% or CAD≥50% in one or more coronary arteries. The burden of coronary calcifications was estimated by angiography visual inspection and classified as absent, mild, moderate or severe. Results Coronary angiography showed single, double and triple vessel disease in 26 (25.7%), 23 (22.8%) and 21 (20.8%) patients, respectively; 20 (19.8%) and 11 (10.9%) pts had either minimal CAD (<50%) or normal angiographic findings. Also, calcifications were absent in 65 patients (64.4%), and mild, moderate and severe in 23 (22.8%), 11 (10.9%) and 2 (2%) patients, respectively. Plasma PCSK9 levels were significantly associated with age (rho=0.22, p=0.025) and SBP (rho=0.21, p=0.034), and were almost doubled in patients with chronic kidney disease (CKD) as compared to those without CKD [164.6 ng/mL (104.6–187.0) vs 94.8 ng/mL (86.8–114.9), p=0.006]. Among patients without CKD, those with CAD≥50% had higher plasma PCSK9 levels than those without [97.1 ng/mL (87.8–143.0) vs 83.2 ng/mL (73.4–102.6), p=0.04]. In the overall population, higher plasma PCSK9 levels were found in pts with triple vessel disease [165.7 ng/mL (121.3–180.5)] than in those with double/single vessel involvement [97.9 ng/mL (87.6–99.8) and 88.4 ng/mL (87.3–97.4), p<0.001 for both comparisons] or without CAD [87.5 ng/mL (74.3–114.9), p<0.001]. Also, a trend toward an increase of plasma PCSK9 levels was found with higher CAD severity [no-CAD: 87.5 ng/mL (74.3–114.9), CAD<50%: 89.1 ng/mL (78.9–105.3), CAD≥50%: 97.6 ng/mL (87.9–155.3), p=0.051], which turned significant after exclusion of CKD patients (p=0.042). Adjustment for age, sex, plasma LDL-cholesterol levels, statin use and CKD abolished the association between PCSK9 and CAD severity but not with the number of significantly diseased vessels and the burden of coronary calcifications. Conclusions Circulating PCSK9, whose plasma levels are significantly influenced by the presence of CKD, discriminates patients with significant coronary artery stenosis from those without CAD. In addition, both the number of diseased coronary vessels and total coronary calcifications are independently predicted by an elevated plasma PCSK9 level. Acknowledgement/Funding None

Value of conventional chest radiography for the detection of coronary calcifications: Comparison with MSCT

2009 ◽  
Vol 69 (3) ◽  
pp. 510-516 ◽  
Author(s):  
Andreas H. Mahnken ◽  
Berthold B. Wein ◽  
Anil M. Sinha ◽  
Rolf W. Günther ◽  
Joachim E. Wildberger
Keyword(s):  
Chest Radiography ◽  
Coronary Calcifications
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