scholarly journals Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold

2018 ◽  
Author(s):  
Li Lin ◽  
Peng Hu ◽  
Junhui Shi ◽  
Konstantin I. Maslov ◽  
Lihong V. Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Breath Hold ◽  
Human Breast ◽  
Single Breath ◽  
Single Breath Hold

scholarly journals Single breath-hold saturation recovery 3D cardiac T1 mapping via compressed SENSE at 3T

2020 ◽  
Vol 33 (6) ◽  
pp. 865-876
Author(s):  
Tiago Ferreira da Silva ◽  
Carlos Galan-Arriola ◽  
Paula Montesinos ◽  
Gonzalo Javier López-Martín ◽  
Manuel Desco ◽  
...  
Keyword(s):  
Heart Rate ◽  
Saturation Recovery ◽  
Acquisition Time ◽  
Breath Hold ◽  
Post Contrast ◽  
In Vivo Experiments ◽  
Single Breath ◽  
Single Breath Hold ◽  
Phantom Experiments

Abstract Objectives To propose and validate a novel imaging sequence that uses a single breath-hold whole-heart 3D T1 saturation recovery compressed SENSE rapid acquisition (SACORA) at 3T. Methods The proposed sequence combines flexible saturation time sampling, compressed SENSE, and sharing of saturation pulses between two readouts acquired at different RR intervals. The sequence was compared with a 3D saturation recovery single-shot acquisition (SASHA) implementation with phantom and in vivo experiments (pre and post contrast; 7 pigs) and was validated against the reference inversion recovery spin echo (IR-SE) sequence in phantom experiments. Results Phantom experiments showed that the T1 maps acquired by 3D SACORA and 3D SASHA agree well with IR-SE. In vivo experiments showed that the pre-contrast and post-contrast T1 maps acquired by 3D SACORA are comparable to the corresponding 3D SASHA maps, despite the shorter acquisition time (15s vs. 188s, for a heart rate of 60 bpm). Mean septal pre-contrast T1 was 1453 ± 44 ms with 3D SACORA and 1460 ± 60 ms with 3D SASHA. Mean septal post-contrast T1 was 824 ± 66 ms and 824 ± 60 ms. Conclusion 3D SACORA acquires 3D T1 maps in 15 heart beats (heart rate, 60 bpm) at 3T. In addition to its short acquisition time, the sequence achieves good T1 estimation precision and accuracy.

scholarly journals Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo

2021 ◽  
Author(s):  
Hailong He ◽  
Christine Schoenmann ◽  
Mathias Schwarz ◽  
Benedikt Hindelang ◽  
Andrei Bereznhoi ◽  
...  
Keyword(s):  
Three Dimensional ◽  
High Sensitivity ◽  
Skin Lesions ◽  
Skin Depth ◽  
Motion Artifacts ◽  
Breath Hold ◽  
Single Breath ◽  
Single Breath Hold ◽  
Raster Scan

The development and progression of melanoma tumors is associated with angiogenesis, manifesting as changes in vessel density, morphology, and architecture that may extend through the entire skin depth. Three-dimensional imaging of vascular characteristics in skin lesions could allow diagnostic insights not available to the conventional visual inspection. Raster-scan optoacoustic mesoscopy (RSOM) has emerged as a unique modality to image microvasculature through the entire skin depth with resolutions of tens of micrometers, offering new possibilities to assess angiogenetic processes. However, current RSOM implementations are slow, exacerbating motion artifacts and reducing image quality, particularly when imaging melanoma lesions that often appear on the upper torso where breathing motion is strongest. To visualize for the first time melanoma vasculature in humans, in high-resolution, we accelerated RSOM scanning using an illumination scheme that is co-axial with a high-sensitivity ultrasound detector path, yielding 15 second single-breath-hold scans that minimize motion artifacts. Applied to 10 melanomas and 10 benign nevi in humans, we demonstrate visualization of microvasculature with performance never before shown in vivo. We show marked differences between malignant and benign lesions, supporting the possibility to use vasculature as a biomarker for lesion characterization. The study points to promising clinical potential for Fast-RSOM (FRSOM) as a three dimensional visualization method that can enable the complete assessment of microvascular parameters of melanoma and improve diagnostics.

scholarly journals Evaluation of pulmonary function using single-breath-hold dual-energy computed tomography with xenon

Medicine ◽  
2017 ◽  
Vol 96 (3) ◽  
pp. e5937 ◽  
Author(s):  
Hiroyuki Kyoyama ◽  
Yusuke Hirata ◽  
Satoshi Kikuchi ◽  
Kosuke Sakai ◽  
Yuriko Saito ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Pulmonary Function ◽  
Dual Energy ◽  
Breath Hold ◽  
Dual Energy Computed Tomography ◽  
Single Breath ◽  
Single Breath Hold

scholarly journals Single-breath-hold photoacoustic computed tomography of the breast

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Li Lin ◽  
Peng Hu ◽  
Junhui Shi ◽  
Catherine M. Appleton ◽  
Konstantin Maslov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Breath Hold ◽  
Single Breath ◽  
Single Breath Hold

scholarly journals High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Li Lin ◽  
Peng Hu ◽  
Xin Tong ◽  
Shuai Na ◽  
Rui Cao ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Speed ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Clinical Translation ◽  
Breath Hold ◽  
Human Breast ◽  
Preclinical Research ◽  
Imaging Depth

AbstractPhotoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications of this technology. To overcome these issues, we developed a three-dimensional photoacoustic computed tomography (3D-PACT) system that features large imaging depth, scalable field of view with isotropic spatial resolution, high imaging speed, and superior image quality. 3D-PACT allows for multipurpose imaging to reveal detailed angiographic information in biological tissues ranging from the rodent brain to the human breast. In the rat brain, we visualize whole brain vasculatures and hemodynamics. In the human breast, an in vivo imaging depth of 4 cm is achieved by scanning the breast within a single breath hold of 10 s. Here, we introduce the 3D-PACT system to provide a unique tool for preclinical research and an appealing prototype for clinical translation.

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