scholarly journals Linear-array based full-view high-resolution photoacoustic computed tomography of whole mouse brain functions in vivo

2018 ◽  
Author(s):  
Lei Li ◽  
Pengfei Zhang ◽  
Lihong Wang
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Mouse Brain ◽  
Linear Array ◽  
Full View ◽  
Brain Functions

scholarly journals Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Philipp S. Lienemann ◽  
Stéphanie Metzger ◽  
Anna-Sofia Kiveliö ◽  
Alain Blanc ◽  
Panagiota Papageorgiou ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Histological Evaluation ◽  
Biological Processes ◽  
Micro Ct ◽  
Pinhole Spect

Abstract Over the last decades, great strides were made in the development of novel implants for the treatment of bone defects. The increasing versatility and complexity of these implant designs request for concurrent advances in means to assess in vivo the course of induced bone formation in preclinical models. Since its discovery, micro-computed tomography (micro-CT) has excelled as powerful high-resolution technique for non-invasive assessment of newly formed bone tissue. However, micro-CT fails to provide spatiotemporal information on biological processes ongoing during bone regeneration. Conversely, due to the versatile applicability and cost-effectiveness, single photon emission computed tomography (SPECT) would be an ideal technique for assessing such biological processes with high sensitivity and for nuclear imaging comparably high resolution (<1 mm). Herein, we employ modular designed poly(ethylene glycol)-based hydrogels that release bone morphogenetic protein to guide the healing of critical sized calvarial bone defects. By combined in vivo longitudinal multi-pinhole SPECT and micro-CT evaluations we determine the spatiotemporal course of bone formation and remodeling within this synthetic hydrogel implant. End point evaluations by high resolution micro-CT and histological evaluation confirm the value of this approach to follow and optimize bone-inducing biomaterials.

scholarly journals Noninvasive quantification of heterogeneous lung growth following extensive lung resection by high-resolution computed tomography

2009 ◽  
Vol 107 (5) ◽  
pp. 1569-1578 ◽  
Author(s):  
Cuneyt Yilmaz ◽  
Priya Ravikumar ◽  
D. Merrill Dane ◽  
Dennis J. Bellotto ◽  
Robert L. Johnson ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Connective Tissue ◽  
Coefficient Of Variation ◽  
Lung Resection ◽  
Lung Growth ◽  
High Resolution Computed Tomography ◽  
Extensive Resection ◽  
Compensatory Lung Growth

To quantify the in vivo magnitude and distribution of regional compensatory lung growth following extensive lung resection, we performed high-resolution computed tomography at 15- and 30-cmH2O transpulmonary pressures and measured air and tissue (including microvascular blood) volumes within and among lobes in six adult male foxhounds, before and after balanced 65% lung resection (∼32% removed from each side). Each lobe was identified from lobar fissures. Intralobar gradients in air and tissue volumes were expressed along standardized x, y, z-coordinate axes. Fractional tissue volume (FTV) was calculated as the volume ratio of tissue/(tissue + air). Following resection compared with before, lobar air and tissue volumes increased 1.8- to 3.5-fold, and whole lung air and tissue volumes were 67 and 90% of normal, respectively. Lobar-specific compliance doubled post-resection, and whole lung-specific compliance normalized. These results are consistent with vigorous compensatory growth in all remaining lobes. Compared with pre-resection, post-resection interlobar heterogeneity of FTV, assessed from the coefficient of variation, decreased at submaximal inflation, but was unchanged at maximal inflation. The coefficient of variation of intralobar FTV gradients changed variably due to the patchy development of thickened pleura and alveolar septa, with elevated alveolar septal density and connective tissue content in posterior-caudal and peripheral regions of the remaining lobes; these areas likely experienced disproportional mechanical stress. We conclude that HRCT can noninvasively and quantitatively assess the magnitude and spatial distribution of compensatory lung growth. Following extensive resection, heterogeneous regional mechanical lung strain may exceed the level that could be sustained solely by existing connective tissue elements.

Resolution, sensitivity, and in vivo application of high-resolution computed tomography for titanium-coated polymethyl methacrylate (PMMA) dental implants

2013 ◽  
Vol 25 (3) ◽  
pp. 359-365 ◽  
Author(s):  
Vincent M. J. I. Cuijpers ◽  
Jacub Jaroszewicz ◽  
Sukumaran Anil ◽  
Abdullah Al Farraj Aldosari ◽  
X. Frank Walboomers ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Dental Implants ◽  
Polymethyl Methacrylate ◽  
High Resolution Computed Tomography

Accuracy of High-resolution Small-volume Cone-Beam Computed Tomography in the Diagnosis of Vertical Root Fracture: An In Vivo Analysis

2020 ◽  
Vol 46 (8) ◽  
pp. 1059-1066 ◽  
Author(s):  
Debora R. Dias ◽  
Lilian C.V. Iwaki ◽  
Alexandre C.A. de Oliveira ◽  
Felipe S. Martinhão ◽  
Robson M. Rossi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Cone Beam Computed Tomography ◽  
Small Volume ◽  
Cone Beam ◽  
Root Fracture ◽  
Vertical Root Fracture ◽  
In Vivo Analysis
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