Examination of single-substance multiphase material distribution in a cylindrical container using acoustic wavenumber spectroscopy

2017 ◽  
Author(s):  
John R. Rees ◽  
Elise Anne C. Koskelo ◽  
Niall M. O'Dowd ◽  
Eric B. Flynn
Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 746
Author(s):  
Magdalena Turk ◽  
Rok Šibanc ◽  
Rok Dreu ◽  
Maja Frankiewicz ◽  
Małgorzata Sznitowska

This study concerned the quality of mini-tablets’ coating uniformity obtained by either the bottom spray chamber with a classical Wurster distributor (CW) or a swirl distributor (SW). Mini-tablets with a diameter of 2.0, 2.5, and 3.0 mm were coated with hypromellose using two different inlet air distributors as well as inlet airflow rates (130 and 156 m3/h). Tartrazine was used as a colorant in the coating layer and the coating uniformity was assessed by spectrophotometric analysis of solutions obtained after disintegration of the mini-tablets (n = 100). Higher uniformity of coating material distribution among the mini-tablets was observed in the case of SW distributor, even for the biggest mini-tablets (d = 3.0 mm), with an RSD no larger than 5.0%. Additionally, coating thickness was evaluated by colorimetric analysis (n = 1000), using a scanner method, and expressed as a hue value. A high correlation (R = 0.993) between inter-tablet variability of hue and UV-Vis results was obtained. Mini-tablets were successfully coated in a fluid bed system using both a classical Wurster distributor as well as a swirl generator. However, regardless of the mini-tablets’ diameter, better film uniformity was achieved in the case of a distributor with a swirl generator.


2021 ◽  
pp. 101900
Author(s):  
Rafael Quelho de Macedo ◽  
Rafael Thiago Luiz Ferreira ◽  
Andrew Gleadall ◽  
Ian Ashcroft

2020 ◽  
Vol 1677 ◽  
pp. 012076
Author(s):  
B. R. Sharifullin ◽  
I. V. Naumov ◽  
M. A. Tsoy ◽  
V. N. Shtern

Nanoscale ◽  
2021 ◽  
Author(s):  
Ning Jiang ◽  
Bo Yang ◽  
Yulong Bai ◽  
Yaoxiang Jiang ◽  
Shifeng Zhao

Both surface and interface scattering induced a sign reversal of anomalous Hall effects (AHE) in a few heterostructures. The sign reversal exiting in a single-substance can clarify the role of...


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