Optical guidance for stereotactic brain tumor biopsy procedures: preliminary clinical evaluation (Conference Presentation)

2017 ◽  
Author(s):  
Neda Haj-Hosseini ◽  
Johan Richter ◽  
Peter Milos ◽  
Martin Hallbeck ◽  
Karin Wårdell
Keyword(s):  
Brain Tumor ◽  
Clinical Evaluation ◽  
Tumor Biopsy

scholarly journals Brain Tumor Mutations Detected in Cerebral Spinal Fluid

2015 ◽  
Vol 61 (3) ◽  
pp. 514-522 ◽  
Author(s):  
Wenying Pan ◽  
Wei Gu ◽  
Seema Nagpal ◽  
Melanie Hayden Gephart ◽  
Stephen R Quake
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Cerebral Spinal Fluid ◽  
Digital Pcr ◽  
Spinal Fluid ◽  
Driver Mutations ◽  
Leptomeningeal Disease ◽  
Tumor Biopsy ◽  
Panel Sequencing ◽  
Cancer Panel

Abstract BACKGROUND Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor patients is challenging, presumably owing to the blood–brain barrier. Cerebral spinal fluid (CSF) may serve as an alternative “liquid biopsy” of brain tumors by enabling measurement of circulating DNA within CSF to characterize tumor-specific mutations. Many aspects about the characteristics and detectability of tumor mutations in CSF remain undetermined. METHODS We used digital PCR and targeted amplicon sequencing to quantify tumor mutations in the cfDNA of CSF and plasma collected from 7 patients with solid brain tumors. Also, we applied cancer panel sequencing to globally characterize the somatic mutation profile from the CSF of 1 patient with suspected leptomeningeal disease. RESULTS We detected tumor mutations in CSF samples from 6 of 7 patients with solid brain tumors. The concentration of the tumor mutant alleles varied widely between patients, from <5 to nearly 3000 copies/mL CSF. We identified 7 somatic mutations from the CSF of a patient with leptomeningeal disease by use of cancer panel sequencing, and the result was concordant with genetic testing on the primary tumor biopsy. CONCLUSIONS Tumor mutations were detectable in cfDNA from the CSF of patients with different primary and metastatic brain tumors. We designed 2 strategies to characterize tumor mutations in CSF for potential clinical diagnosis: the targeted detection of known driver mutations to monitor brain metastasis and the global characterization of genomic aberrations to direct personalized cancer care.

Predictive value of clinical evaluation in the follow-up of children with a brain tumor

2002 ◽  
Vol 38 (4) ◽  
pp. 254-257 ◽  
Author(s):  
Nanko de Graaf ◽  
Joffre M. Hew ◽  
Johanna M. Fock ◽  
Willem A. Kamps ◽  
Siebold S.N. de Graaf
Keyword(s):  
Brain Tumor ◽  
Clinical Evaluation ◽  
Predictive Value

Automated Brain Tumor Biopsy Prediction Using Single-labeling cDNA Microarrays-based Gene Expression Profiling

2009 ◽  
Vol 18 (4) ◽  
pp. 206-218 ◽  
Author(s):  
Xavier Castells ◽  
Juan Miguel García-Gómez ◽  
Alfredo Navarro ◽  
Juan José Acebes ◽  
Óscar Godino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Tumor ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Cdna Microarrays ◽  
Tumor Biopsy

Is Intraoperative Pathology Needed if 5-Aminolevulinic-Acid-Induced Tissue Fluorescence Is Found in Stereotactic Brain Tumor Biopsy?

Neurosurgery ◽  
2019 ◽  
Author(s):  
Matthias Millesi ◽  
Barbara Kiesel ◽  
Adelheid Wöhrer ◽  
Petra A Mercea ◽  
Marco Bissolo ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Aminolevulinic Acid ◽  
Tumor Biopsy ◽  
Tissue Fluorescence

scholarly journals CT Guided Stereotactic Brain Tumor Biopsy

2020 ◽  
Vol 9 (2) ◽  
pp. 86-93
Author(s):  
Moududul Haque ◽  
Sudipta Kumar Mukherjee ◽  
Mustafa Kamal ◽  
ABM Manwar Hossain
Keyword(s):  
Brain Tumor ◽  
Stereotactic Biopsy ◽  
Low Cost ◽  
Brain Lesions ◽  
Normal Brain ◽  
Normal Brain Tissue ◽  
Tumor Biopsy ◽  
Ct Guided ◽  
Image Guided ◽  
Stereotactic Biopsies

153 cases of CT guided stereotactic biopsies for intra-axial deep seated brain lesions performed by one neurosurgeon has been analyzed regarding procedure, success rate and complications. Of the 153 cases, positive tissue biopsy was found in 143 cases. In 6 patients, biopsy showed gliotic grain tissue or normal brain tissue.4 patients had complications after the procedure. Three patient developed intracerebral haemorrhage of the two died, and other died Massive MI. There was no post operative new deficits seen. CT guided Stereotactic biopsy is a very effective and low cost procedure caomparing with frameless image guided brain biopsies or open craniotomy for biopsy due to it’s higher complication rate. The detail procedure are being discussed Bang. J Neurosurgery 2020; 9(2): 86-93

scholarly journals High-resolution whole-brain DCE-MRI using constrained reconstruction: Prospective clinical evaluation in brain tumor patients

2016 ◽  
Vol 43 (5) ◽  
pp. 2013-2023 ◽  
Author(s):  
Yi Guo ◽  
R. Marc Lebel ◽  
Yinghua Zhu ◽  
Sajan Goud Lingala ◽  
Mark S. Shiroishi ◽  
...  
Keyword(s):  
Brain Tumor ◽  
High Resolution ◽  
Clinical Evaluation ◽  
Tumor Patients ◽  
Constrained Reconstruction ◽  
Whole Brain ◽  
Dce Mri

Freehand Two-Step CT-Guided Brain Tumor Biopsy: A Fast and Effective Interventional Procedure in Selected Patients

2005 ◽  
Vol 29 (2) ◽  
pp. 264-269 ◽  
Author(s):  
Loukas Thanos ◽  
Sofia Mylona ◽  
Panagiota Galani ◽  
Vasilios Kalioras ◽  
Maria Pomoni ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Interventional Procedure ◽  
Tumor Biopsy ◽  
Ct Guided
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