Empirical neural network forward model for maximum likelihood material decomposition in spectral CT

2017 ◽  
Author(s):  
Kevin C. Zimmerman ◽  
Adam Petschke
Author(s):  
Suzanne Bussod ◽  
Juan F.P.J. Abascal ◽  
Simon Arridge ◽  
Andreas Hauptmann ◽  
Christine Chappard ◽  
...  

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 953
Author(s):  
Florian T. Gassert ◽  
Johannes Hammel ◽  
Felix C. Hofmann ◽  
Jan Neumann ◽  
Claudio E. von Schacky ◽  
...  

The aim of this study is to assess whether perifocal bone marrow edema (BME) in patients with osteoid osteoma (OO) can be accurately detected on dual-layer spectral CT (DLCT) with three-material decomposition. To that end, 18 patients with OO (25.33 ± 12.44 years; 7 females) were pairwise-matched with 18 patients (26.72 ± 9.65 years; 9 females) admitted for suspected pathologies other than OO in the same anatomic location but negative imaging findings. All patients were examined with DLCT and MRI. DLCT data was decomposed into hydroxyapatite and water- and fat-equivalent volume fraction maps. Two radiologists assessed DLCT-based volume fraction maps for the presence of perifocal BME, using a Likert scale (1 = no edema; 2 = likely no edema; 3 = likely edema; 4 = edema). Accuracy, sensitivity, and specificity for the detection of BME on DLCT were analyzed using MR findings as standard of reference. For the detection of BME in patients with OO, DLCT showed a sensitivity of 0.92, a specificity of 0.94, and an accuracy of 0.92 for both radiologists. Interreader agreement for the assessment of BME with DLCT was substantial (weighted κ = 0.78; 95% CI, 0.59, 0.94). DLCT with material-specific volume fraction maps allowed accurate detection of BME in patients with OO. This may spare patients additional examinations and facilitate the diagnosis of OO.


IEEE Access ◽  
2020 ◽  
pp. 1-1
Author(s):  
Xiaojie Lv ◽  
Xuezhi Ren ◽  
Peng He ◽  
Mi Zhou ◽  
Zourong Long ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Guanglei Xu ◽  
William S. Oates

AbstractRestricted Boltzmann Machines (RBMs) have been proposed for developing neural networks for a variety of unsupervised machine learning applications such as image recognition, drug discovery, and materials design. The Boltzmann probability distribution is used as a model to identify network parameters by optimizing the likelihood of predicting an output given hidden states trained on available data. Training such networks often requires sampling over a large probability space that must be approximated during gradient based optimization. Quantum annealing has been proposed as a means to search this space more efficiently which has been experimentally investigated on D-Wave hardware. D-Wave implementation requires selection of an effective inverse temperature or hyperparameter ($$\beta $$ β ) within the Boltzmann distribution which can strongly influence optimization. Here, we show how this parameter can be estimated as a hyperparameter applied to D-Wave hardware during neural network training by maximizing the likelihood or minimizing the Shannon entropy. We find both methods improve training RBMs based upon D-Wave hardware experimental validation on an image recognition problem. Neural network image reconstruction errors are evaluated using Bayesian uncertainty analysis which illustrate more than an order magnitude lower image reconstruction error using the maximum likelihood over manually optimizing the hyperparameter. The maximum likelihood method is also shown to out-perform minimizing the Shannon entropy for image reconstruction.


2011 ◽  
Vol 58-60 ◽  
pp. 1847-1853 ◽  
Author(s):  
Yan Zhang ◽  
Cun Bao Chen ◽  
Li Zhao

In this paper, Gaussian Mixture model (GMM) as specific method is applied to noise classification. On this basis, a modified Gaussian Mixture Model with an embedded Auto-Associate Neural Network (AANN) is proposed. It integrates the merits of GMM and AANN. We train GMM and AANN as a whole and they are trained by means of Maximum Likelihood (ML). In the process of training, the parameter of GMM and AANN are updated alternately. AANN reshapes the distribution of the data and improves the similarity of the feature data in the same distribution type of noise. Experiments show that the GMM with embedded AANN improves accuracy rate of noise classification against baseline GMM.


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