Ultrafast laser energy deposition in copper revealed by simulation and experimental determination of optical properties with pump-probe ellipsometry

2017 ◽  
Author(s):  
Jan Winter ◽  
Stephan Rapp ◽  
Michael Schmidt ◽  
Heinz P. Huber
Keyword(s):  
Optical Properties ◽  
Experimental Determination ◽  
Energy Deposition ◽  
Laser Energy ◽  
Ultrafast Laser ◽  
Pump Probe

Computational Simulation of Temperature Elevations in Tumors Using Monte Carlo Method and Comparison to Experimental Measurements in Laser Photothermal Therapy

2013 ◽  
Vol 135 (12) ◽  
Author(s):  
Navid Manuchehrabadi ◽  
Yonghui Chen ◽  
Alexander LeBrun ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Monte Carlo ◽  
Optical Properties ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Energy Deposition ◽  
Thermal Damage ◽  
Laser Energy ◽  
Simulated Temperature ◽  
Laser Energy Absorption ◽  
Laser Photothermal Therapy

Accurate simulation of temperature distribution in tumors induced by gold nanorods during laser photothermal therapy relies on precise measurements of thermal, optical, and physiological properties of the tumor with or without nanorods present. In this study, a computational Monte Carlo simulation algorithm is developed to simulate photon propagation in a spherical tumor to calculate laser energy absorption in the tumor and examine the effects of the absorption (μa) and scattering (μs) coefficients of tumors on the generated heating pattern in the tumor. The laser-generated energy deposition distribution is then incorporated into a 3D finite-element model of prostatic tumors embedded in a mouse body to simulate temperature elevations during laser photothermal therapy using gold nanorods. The simulated temperature elevations are compared with measured temperatures in PC3 prostatic tumors in our previous in vivo experimental studies to extract the optical properties of PC3 tumors containing different concentrations of gold nanorods. It has been shown that the total laser energy deposited in the tumor is dominated by μa, while both μa and μs shift the distribution of the energy deposition in the tumor. Three sets of μa and μs are extracted, representing the corresponding optical properties of PC3 tumors containing different concentrations of nanorods to laser irradiance at 808 nm wavelength. With the injection of 0.1 cc of a 250 optical density (OD) nanorod solution, the total laser energy absorption rate is increased by 30% from the case of injecting 0.1 cc of a 50 OD nanorod solution, and by 125% from the control case without nanorod injection. Based on the simulated temperature elevations in the tumor, it is likely that after heating for 15 min, permanent thermal damage occurs in the tumor injected with the 250 OD nanorod solution, while thermal damage to the control tumor and the one injected with the 50 OD nanorod solution may be incomplete.

Theoretical and experimental determination of optical and magneto-optical properties of LuFe2 single crystal

1998 ◽  
Vol 313-314 ◽  
pp. 222-227 ◽  
Author(s):  
S.J. Lee ◽  
R.J. Lange ◽  
S. Hong ◽  
S. Zollner ◽  
P.C. Canfield ◽  
...  
Keyword(s):  
Optical Properties ◽  
Single Crystal ◽  
Experimental Determination

Experimental determination of a state equation for dissipative granular gases

1999 ◽  
Vol 96 (6) ◽  
pp. 1111-1116 ◽  
Author(s):  
E. Falcon ◽  
S. Fauve ◽  
C. Laroche
Keyword(s):  
Experimental Determination ◽  
State Equation ◽  
Granular Gases
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