Projection-based motion estimation for cardiac functional analysis with high temporal resolution: a proof-of-concept study with digital phantom experiment

2017 ◽  
Author(s):  
Yuki Suzuki ◽  
George S. K. Fung ◽  
Zeyang Shen ◽  
Yoshito Otake ◽  
Okkyun Lee ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Motion Estimation ◽  
Temporal Resolution ◽  
High Temporal Resolution ◽  
Proof Of Concept ◽  
Phantom Experiment ◽  
Concept Study ◽  
Digital Phantom

scholarly journals The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Frans Vinberg ◽  
Tian Wang ◽  
Alicia De Maria ◽  
Haiqing Zhao ◽  
Steven Bassnett ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Temporal Resolution ◽  
Light Adaptation ◽  
Critical Role ◽  
High Temporal Resolution ◽  
Deficient Mouse ◽  
Operating Range ◽  
Response Recovery ◽  
Wide Operating

Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation. Despite the critical role of Ca2+ in supporting the function and survival of cones, the mechanism for its extrusion from cone outer segments is not well understood. Here, we show that the Na+/Ca2+, K+ exchanger NCKX4 is expressed in zebrafish, mouse, and primate cones. Functional analysis of NCKX4-deficient mouse cones revealed that this exchanger is essential for the wide operating range and high temporal resolution of cone-mediated vision. We show that NCKX4 shapes the cone photoresponse together with the cone-specific NCKX2: NCKX4 acts early to limit response amplitude, while NCKX2 acts late to further accelerate response recovery. The regulation of Ca2+ by NCKX4 in cones is a novel mechanism that supports their ability to function as daytime photoreceptors and promotes their survival.

scholarly journals Automatic Definition of an Anatomic Field of View for Volumetric Cardiac Motion Estimation at High Temporal Resolution

2017 ◽  
Vol 7 (7) ◽  
pp. 752 ◽  
Author(s):  
Alejandra Ortega ◽  
João Pedrosa ◽  
Brecht Heyde ◽  
Ling Tong ◽  
Jan D’hooge
Keyword(s):  
Motion Estimation ◽  
Temporal Resolution ◽  
Cardiac Motion ◽  
Field Of View ◽  
High Temporal Resolution ◽  
Definition Of

Multidetector-row Computed Tomography in the Assessment of Coronary Artery Disease – New Techniques and Insights

2010 ◽  
Vol 6 (2) ◽  
pp. 43 ◽  
Author(s):  
Andreas H Mahnken ◽  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Data Acquisition ◽  
Temporal Resolution ◽  
High Temporal Resolution ◽  
Multidetector Row ◽  
Ct Scanners ◽  
Artery Disease ◽  
Cardiac Mdct

Over the last decade, cardiac computed tomography (CT) technology has experienced revolutionary changes and gained broad clinical acceptance in the work-up of patients suffering from coronary artery disease (CAD). Since cardiac multidetector-row CT (MDCT) was introduced in 1998, acquisition time, number of detector rows and spatial and temporal resolution have improved tremendously. Current developments in cardiac CT are focusing on low-dose cardiac scanning at ultra-high temporal resolution. Technically, there are two major approaches to achieving these goals: rapid data acquisition using dual-source CT scanners with high temporal resolution or volumetric data acquisition with 256/320-slice CT scanners. While each approach has specific advantages and disadvantages, both technologies foster the extension of cardiac MDCT beyond morphological imaging towards the functional assessment of CAD. This article examines current trends in the development of cardiac MDCT.

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