UV fluorescence excitation spectroscopy as a non-invasive predictor of epidermal proliferation and clinical performance of cosmetic formulations

2017 ◽  
Author(s):  
Robert Maidhof ◽  
Frank Liebel ◽  
Cheng Hwang ◽  
Eduardo Ruvolo ◽  
John Lyga
Keyword(s):  
Clinical Performance ◽  
Fluorescence Excitation ◽  
Uv Fluorescence ◽  
Non Invasive ◽  
Epidermal Proliferation ◽  
Cosmetic Formulations

scholarly journals Accuracy of BIS monitoring using a novel interface device connecting conventional needle-electrodes and BIS sensors during frontal neurosurgical procedures

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258647
Author(s):  
Hideki Harada ◽  
Seiya Muta ◽  
Tatsuyuki Kakuma ◽  
Misa Ukeda ◽  
So Ota ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Mixed Model ◽  
Clinical Performance ◽  
Clinical Situation ◽  
Electrode Placement ◽  
Neurosurgical Procedures ◽  
Non Invasive ◽  
Invasive Method ◽  
Data Points ◽  
Interface Device

Background Bispectral index (BIS) monitoring is a widely used non-invasive method to monitor the depth of anesthesia. However, in the event of surgeries requiring a frontal approach, placement of the electrode may be impossible at the designated area to achieve a proper BIS measurement. Methods We developed an investigational interface device to connect needle-electrodes to BIS sensors. The safety and clinical performance were investigated in patients who underwent surgery. Direct BIS values from a disposable BIS electrode and indirect values via the interface device were simultaneously recorded from the same areas of electrode placement in a single patient. The agreement between the direct and indirect BIS values was statistically analyzed. Results The interface device with a silver electrode demonstrated sufficient electric conduction to transmit electroencephalogram signals. The overall BIS curves were similar to those of direct BIS monitoring. Direct and indirect BIS values from 18 patients were statistically analyzed using a linear mixed model and a significant concordance was confirmed (indirect BIS = 7.0405 + 0.8286 * direct BIS, p<0.0001). Most observed data (2582/2787 data points, 92.64%) had BIS unit differences of 10 or less. Conclusions The interface device provides an opportunity for intraoperative BIS monitoring of patients, whose clinical situation does not permit the placement of conventional adhesive sensors at the standard location.

scholarly journals Clinical Performance of a New Biomimetic Double Network Material

2013 ◽  
Vol 7 (1) ◽  
pp. 118-122 ◽  
Author(s):  
Christine Dirxen ◽  
Uwe Blunck ◽  
Saskia Preissner
Keyword(s):  
Soft Tissues ◽  
Clinical Performance ◽  
Young Patients ◽  
Tooth Wear ◽  
Clinical Situation ◽  
Dental Erosion ◽  
Thin Layers ◽  
Invasive Treatment ◽  
Tooth Structure ◽  
Non Invasive

Background:The development of ceramics during the last years was overwhelming. However, the focus was laid on the hardness and the strength of the restorative materials, resulting in high antagonistic tooth wear. This is critical for patients with bruxism.Objectives:The purpose of this study was to evaluate the clinical performance of the new double hybrid material for non-invasive treatment approaches.Material and Methods:The new approach of the material tested, was to modify ceramics to create a biomimetic material that has similar physical properties like dentin and enamel and is still as strong as conventional ceramics.Results:The produced crowns had a thickness ranging from 0.5 to 1.5 mm. To evaluate the clinical performance and durability of the crowns, the patient was examined half a year later. The crowns were still intact and soft tissues appeared healthy and this was achieved without any loss of tooth structure.Conclusions:The material can be milled to thin layers, but is still strong enough to prevent cracks which are stopped by the interpenetrating polymer within the network. Depending on the clinical situation, minimally- up to non-invasive restorations can be milled.Clinical Relevance:Dentistry aims in preservation of tooth structure. Patients suffering from loss of tooth structure (dental erosion, Amelogenesis imperfecta) or even young patients could benefit from minimally-invasive crowns. Due to a Vickers hardness between dentin and enamel, antagonistic tooth wear is very low. This might be interesting for treating patients with bruxism.

scholarly journals UV fluorescence excitation imaging of healing of wounds in skin: Evaluation of wound closure in organ culture model

2016 ◽  
Vol 48 (7) ◽  
pp. 678-685 ◽  
Author(s):  
Ying Wang ◽  
Enoch Gutierrez‐Herrera ◽  
Antonio Ortega‐Martinez ◽  
Richard Rox Anderson ◽  
Walfre Franco
Keyword(s):  
Organ Culture ◽  
Wound Closure ◽  
Fluorescence Excitation ◽  
Uv Fluorescence ◽  
Culture Model ◽  
Healing Of Wounds
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