Single-molecule DNA hybridization on nanoporous gold nanoparticle array chip

2017 ◽  
Author(s):  
Jingting Li ◽  
Fusheng Zhao ◽  
Wei-Chuan Shih
Keyword(s):  
Gold Nanoparticle ◽  
Single Molecule ◽  
Dna Hybridization ◽  
Nanoporous Gold ◽  
Nanoparticle Array

scholarly journals Sensitive and Reproducible Gold SERS Sensor Based on Interference Lithography and Electrophoretic Deposition

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 4076 ◽  
Author(s):  
June Hwang ◽  
Minyang Yang
Keyword(s):  
Gold Nanoparticle ◽  
Electrophoretic Deposition ◽  
Large Scale ◽  
Surface Enhanced Raman Spectroscopy ◽  
Localized Surface Plasmon ◽  
Interference Lithography ◽  
Metal Nanostructures ◽  
Nanoparticle Array ◽  
Laser Ablation In Liquid ◽  
Label Free Detection

Surface-enhanced Raman spectroscopy (SERS) is a promising analytical tool due to its label-free detection ability and superior sensitivity, which enable the detection of single molecules. Since its sensitivity is highly dependent on localized surface plasmon resonance, various methods have been applied for electric field-enhanced metal nanostructures. Despite the intensive research on practical applications of SERS, fabricating a sensitive and reproducible SERS sensor using a simple and low-cost process remains a challenge. Here, we report a simple strategy to produce a large-scale gold nanoparticle array based on laser interference lithography and the electrophoretic deposition of gold nanoparticles, generated through a pulsed laser ablation in liquid process. The fabricated gold nanoparticle array produced a sensitive, reproducible SERS signal, which allowed Rhodamine 6G to be detected at a concentration as low as 10−8 M, with an enhancement factor of 1.25 × 105. This advantageous fabrication strategy is expected to enable practical SERS applications.

scholarly journals Facile Detection and Quantification of Acetamiprid Using a Portable Raman Spectrometer Combined with Self-Assembled Gold Nanoparticle Array

Chemosensors ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 327
Author(s):  
Panxue Wang ◽  
Yan Sun ◽  
Li Wang ◽  
Xiang Li ◽  
Miaomiao Liu ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Correlation Coefficients ◽  
Nanoparticle Array ◽  
Sers Signal ◽  
Sers Substrates ◽  
Specificity And Sensitivity ◽  
Exciting Opportunity ◽  
Sers Detection ◽  
Self Assembled ◽  
Detection And Quantification

Rapid and facile determination of pesticides is critically important in food and environmental monitoring. This study developed a self-assembled gold nanoparticle array based SERS method for highly specific and sensitive detection of acetamiprid, a neonicotinoid pesticide that used to be difficult in SERS analysis due to its low affinity with SERS substrates. SERS detection and quantification of acetamiprid was conducted with self-assembled gold nanoparticle arrays at the interface of chloroform and water as the enhancing substrate. Since targets dissolved in chloroform (organic phase) also have access to the hot-spots of Au NP array, the developed method exhibited good sensitivity and specificity for acetamiprid determination. Under the optimal conditions, SERS intensities at Raman shifts of 631 cm−1 and 1109 cm−1 displayed a good linear relationship with the logarithm concentration of acetamiprid in the range of 5.0 × 10−7 to 1.0 × 10−4 mol/L (0.11335 ppm to 22.67 ppm), with correlation coefficients of 0.97972 and 0.97552, respectively. The calculated LOD and LOQ of this method were 1.19 × 10−7 mol/L (0.265 ppb) and 2.63 × 10−7 mol/L (0.586 ppb), respectively, using SERS signal at 631 cm−1, and 2.95 × 10−7 mol/L (0.657 ppb) and 3.86 × 10−7 mol/L (0.860 ppb) using SERS signal at 1109 cm−1, respectively. Furthermore, the developed SERS method was successfully applied in determining acetamiprid on the surface of apple and spinach. This method offers an exciting opportunity for rapid detection of acetamiprid and other organic pesticides considering its advantages of simple preparation process, good specificity and sensitivity, and short detection time (within 1 h).

One-step integration of a multiple-morphology gold nanoparticle array on a TiO2filmviaa facile sonochemical method for highly efficient organic photovoltaics

2018 ◽  
Vol 6 (18) ◽  
pp. 8419-8429 ◽  
Author(s):  
Weijing Shao ◽  
Zhiqiang Liang ◽  
Tianfu Guan ◽  
Jianmei Chen ◽  
Zhifang Wang ◽  
...  
Keyword(s):  
Thin Film ◽  
Absorption Band ◽  
Gold Nanoparticle ◽  
Organic Photovoltaics ◽  
Device Performance ◽  
Sonochemical Method ◽  
Nanoparticle Array ◽  
Au Nps ◽  
Highly Efficient ◽  
One Step

Well-dispersed Au NPs arrays with multiple morphology are integrated on a TiO2thin filmviaa facile sonochemical approach, which exhibit a broadened absorption band, and enable a noticeable enhancement in device performance of organic photovoltaics.

scholarly journals Comparison of in-vitro and in-vivo DNA Hybridization Kinetics using 3D Single-Molecule Tracking Method

2020 ◽  
Vol 118 (3) ◽  
pp. 616a
Author(s):  
Yuan-I Chen ◽  
Yin-Jui Chang ◽  
Trung D. Nguyen ◽  
Cong Liu ◽  
Stephanie Phillion ◽  
...  
Keyword(s):  
Single Molecule ◽  
Dna Hybridization ◽  
Single Molecule Tracking ◽  
Tracking Method

The Structural Characterization of Oligonucleotide-Modified Gold Nanoparticle Networks Formed by DNA Hybridization

2004 ◽  
Vol 108 (33) ◽  
pp. 12375-12380 ◽  
Author(s):  
So-Jung Park ◽  
Anne A. Lazarides ◽  
James J. Storhoff ◽  
Lorenzo Pesce ◽  
Chad A. Mirkin
Keyword(s):  
Gold Nanoparticle ◽  
Structural Characterization ◽  
Dna Hybridization
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