Photothermal therapy to damage PC3 cancer cells: in vitro studies of a pulsed laser (Conference Presentation)

2017 ◽  
Author(s):  
Noe Zamora-Romero ◽  
Guillermo Aguilar ◽  
Luis F. Devia-Cruz ◽  
Darren Banks ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Pulsed Laser ◽  
In Vitro Studies

In vitro studies of glucose concentrations for Cell viability in normal and cancer cells

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
MOUNICA RAJU DANTULURI ◽  
ANIMISHA MOKKAPATI ◽  
RADHAKRISHNA NAGUMANTRI ◽  
SATYANARAYANA RENTALA
Keyword(s):  
Cell Viability ◽  
Cancer Cells ◽  
In Vitro Studies

scholarly journals Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoxia Song ◽  
Zhi Chen ◽  
Xue Zhang ◽  
Junfeng Xiong ◽  
Teng Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Stimuli Responsive ◽  
Lung Cancer Cell ◽  
Precise Movement ◽  
Photothermal Property

AbstractMagnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.

CORMs loaded nanoplatform for the single NIR light-activated bioimaging, gas therapy, and photothermal therapy in vitro

2021 ◽  
Author(s):  
Shihao Pei ◽  
Jia-Bei Li ◽  
Zhuo Wang ◽  
Yao Xie ◽  
Jiabo Chen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Cancer Treatment ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Nir Light ◽  
Potential Alternative

Carbon monoxide (CO) can cause mitochondrial dysfunction, inducing apoptosis of cancer cells which sheds light on a potential alternative for cancer treatment. However, the existing CO-based compounds are inherently limited...

In vivo and in vitro studies of anticancer actions of α-TEA for human prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (8) ◽  
pp. 849-860 ◽  
Author(s):  
Li Jia ◽  
Weiping Yu ◽  
Pei Wang ◽  
Bob G. Sanders ◽  
Kimberly Kline
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
In Vitro Studies ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

pH-Responsible fluorescent carbon nanoparticles for tumor selective theranostics via pH-turn on/off fluorescence and photothermal effect in vivo and in vitro

Nanoscale ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 2512-2523 ◽  
Author(s):  
Eun Bi Kang ◽  
Jung Eun Lee ◽  
Zihnil Adha Islamy Mazrad ◽  
Insik In ◽  
Ji Hoon Jeong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Carbon Nanoparticles ◽  
Fluorescence Probes ◽  
Photothermal Effect ◽  
Turn On ◽  
Fluorescent Carbon Nanoparticles ◽  
Tumor Selective

Here we designed the functionalized FNP as “switch-on” fluorescence probes to sense intracellular cancer cells and controllable photothermal therapy (PTT) in vivo and in vitro.

Liposomes for dihydroartemisinin delivery to cancer cells: development, characterization and in vitro studies

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Coronnello ◽  
A Mastrantoni ◽  
M Bergonzi ◽  
A Bilia
Keyword(s):  
Cancer Cells ◽  
In Vitro Studies

scholarly journals Improving Plasmonic Photothermal Therapy of Lung Cancer Cells with Anti-EGFR Targeted Gold Nanorods

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1307 ◽  
Author(s):  
Oscar Knights ◽  
Steven Freear ◽  
James R. McLaughlan
Keyword(s):  
Lung Cancer ◽  
Minimally Invasive ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Continuous Wave ◽  
Treatment Options ◽  
Lung Cancer Cells ◽  
Heat Conducting

Lung cancer is a particularly difficult form of cancer to diagnose and treat, due largely to the inaccessibility of tumours and the limited available treatment options. The development of plasmonic gold nanoparticles has led to their potential use in a large range of disciplines, and they have shown promise for applications in this area. The ability to functionalise these nanoparticles to target to specific cancer types, when combined with minimally invasive therapies such as photothermal therapy, could improve long-term outcomes for lung cancer patients. Conventionally, continuous wave lasers are used to generate bulk heating enhanced by gold nanorods that have accumulated in the target region. However, there are potential negative side-effects of heat-induced cell death, such as the risk of damage to healthy tissue due to heat conducting to the surrounding environment, and the development of heat and drug resistance. In this study, the use of pulsed lasers for photothermal therapy was investigated and compared with continuous wave lasers for gold nanorods with a surface plasmon resonance at 850 nm, which were functionalised with anti-EGFR antibodies. Photothermal therapy was performed with both laser systems, on lung cancer cells (A549) in vitro populations incubated with untargeted and targeted nanorods. It was shown that the combination of pulse wave laser illumination of targeted nanoparticles produced a reduction of 93 % ± 13 % in the cell viability compared with control exposures, which demonstrates a possible application for minimally invasive therapies for lung cancer.

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