Differentiating functional brain regions using optical coherence tomography (Conference Presentation)

2017 ◽  
Author(s):  
Daniel A. Gil ◽  
Hansen C. Bow ◽  
Jin-H. Shen ◽  
Karen M. Joos ◽  
Melissa C. Skala
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Regions ◽  
Optical Coherence ◽  
Functional Brain

scholarly journals Noninvasive, in vivo imaging of subcortical mouse brain regions with 17  μm optical coherence tomography

2015 ◽  
Vol 40 (21) ◽  
pp. 4911 ◽  
Author(s):  
Shau Poh Chong ◽  
Conrad W. Merkle ◽  
Dylan F. Cooke ◽  
Tingwei Zhang ◽  
Harsha Radhakrishnan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Mouse Brain ◽  
In Vivo Imaging ◽  
Brain Regions ◽  
Optical Coherence

scholarly journals Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

2019 ◽  
Vol 9 (10) ◽  
pp. 2100 ◽  
Author(s):  
Johanna Gesperger ◽  
Antonia Lichtenegger ◽  
Thomas Roetzer ◽  
Marco Augustin ◽  
Danielle J. Harper ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Amyloid Beta ◽  
Cross Sections ◽  
Imaging Modality ◽  
Three Dimensional ◽  
Brain Regions ◽  
Optical Coherence ◽  
Amyloid Beta Protein ◽  
Tissue Sections ◽  
Cortical Regions

One key hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining of different brain regions, is required. Here, we present optical coherence tomography (OCT) as a tissue-preserving imaging modality for the visualization of amyloid-beta plaques and compare their contrast in intensity- and polarization-sensitive (PS) OCT. Human brain samples of eleven patients diagnosed with AD were imaged. Three-dimensional PS-OCT datasets were acquired and plaques were manually segmented in 500 intensity and retardation cross-sections per patient using the freely available ITK-SNAP software. The image contrast of plaques was quantified. Histological staining of tissue sections from the same specimens was performed to compare OCT findings against the gold standard. Furthermore, the distribution of plaques was evaluated for intensity-based OCT, PS-OCT and the corresponding histological amyloid-beta staining. Only 5% of plaques were visible in both intensity and retardation segmentations, suggesting that different types of plaques may be visualized by the two OCT contrast channels. Our results indicate that multicontrast OCT imaging might be a promising approach for a tissue-preserving visualization of amyloid-beta plaques in AD.

scholarly journals Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation

2009 ◽  
Vol 178 (1) ◽  
pp. 162-173 ◽  
Author(s):  
Yu Chen ◽  
Aaron D. Aguirre ◽  
Lana Ruvinskaya ◽  
Anna Devor ◽  
David A. Boas ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Activation ◽  
Optical Coherence ◽  
Functional Brain

J022021 3-dimensional and micro-scale functional brain imaging using optical coherence tomography based on Fourier analysis

2011 ◽  
Vol 2011 (0) ◽  
pp. _J022021-1-_J022021-4
Author(s):  
Yu NAKAMICHI ◽  
Valery A. KALATSKY ◽  
Hideyuki WATANABE ◽  
Uma Maheswari RAJAGOPALAN ◽  
Manabu TANIFUJI
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Analysis ◽  
Brain Imaging ◽  
Functional Brain Imaging ◽  
Optical Coherence ◽  
Functional Brain ◽  
3 Dimensional ◽  
Micro Scale

1086: Cystoscopic Optical Coherence Tomography in Diagnosis and Management of Clinical Bladder Tumors

2007 ◽  
Vol 177 (4S) ◽  
pp. 358-359 ◽  
Author(s):  
Christopher S. Lee ◽  
Alek Mishail ◽  
Jason M. Kim ◽  
Alexander Kirshenbaum ◽  
Howard L. Adler ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Tumors ◽  
Diagnosis And Management

1227: Optical Coherence Tomography-Guided Surgery of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 395-395
Author(s):  
Nancy J. Tresser ◽  
Elena V. Zagaynova ◽  
Olga S. Streltsova ◽  
Natalia D. Gladkova ◽  
Vladislav A. Kamensky ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Guided Surgery

258: Diagnosis and Intraoperative Staging of Bladder Disease by in-vivo Optical Coherence Tomography (OCT)

2004 ◽  
Vol 171 (4S) ◽  
pp. 68-68 ◽  
Author(s):  
Markus D. Sachs ◽  
Dmitry Daniltchenko ◽  
Eva Lankenau ◽  
Frank Koenig ◽  
Gerion Huettmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Disease
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