Optogenetic pacing in Drosophila models (Conference Presentation)

2017 ◽  
Author(s):  
Penghe Wu ◽  
Airong Li ◽  
Jing Men ◽  
Rudolph E. Tans ◽  
Chao Zhou
Keyword(s):  
Drosophila Models

scholarly journals Ku70 Alleviates Neurodegeneration in Drosophila Models of Huntington's Disease

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27408 ◽  
Author(s):  
Takuya Tamura ◽  
Masaki Sone ◽  
Takeshi Iwatsubo ◽  
Kazuhiko Tagawa ◽  
Erich E. Wanker ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Drosophila Models

scholarly journals L-Carnitine in Drosophila: A Review

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1310
Author(s):  
Maria Rosaria Carillo ◽  
Carla Bertapelle ◽  
Filippo Scialò ◽  
Mario Siervo ◽  
Gianrico Spagnuolo ◽  
...  
Keyword(s):  
Transport System ◽  
Essential Role ◽  
Energy Homeostasis ◽  
Current Knowledge ◽  
Fatty Acyl ◽  
Amino Acid Derivative ◽  
Carnitine Transport ◽  
Human Transport ◽  
Drosophila Models

L-Carnitine is an amino acid derivative that plays a key role in the metabolism of fatty acids, including the shuttling of long-chain fatty acyl CoA to fuel mitochondrial β-oxidation. In addition, L-carnitine reduces oxidative damage and plays an essential role in the maintenance of cellular energy homeostasis. L-carnitine also plays an essential role in the control of cerebral functions, and the aberrant regulation of genes involved in carnitine biosynthesis and mitochondrial carnitine transport in Drosophila models has been linked to neurodegeneration. Drosophila models of neurodegenerative diseases provide a powerful platform to both unravel the molecular pathways that contribute to neurodegeneration and identify potential therapeutic targets. Drosophila can biosynthesize L-carnitine, and its carnitine transport system is similar to the human transport system; moreover, evidence from a defective Drosophila mutant for one of the carnitine shuttle genes supports the hypothesis of the occurrence of β-oxidation in glial cells. Hence, Drosophila models could advance the understanding of the links between L-carnitine and the development of neurodegenerative disorders. This review summarizes the current knowledge on L-carnitine in Drosophila and discusses the role of the L-carnitine pathway in fly models of neurodegeneration.

scholarly journals Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

2017 ◽  
Vol 2 ◽  
pp. 15-26 ◽  
Author(s):  
Stephane Dissel ◽  
Markus Klose ◽  
Jeff Donlea ◽  
Lijuan Cao ◽  
Denis English ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Deficits ◽  
Underlying Pathology ◽  
Drosophila Models
Sign in / Sign up

Export Citation Format

Share Document