Controllable gas in oil in water double emulsion formation in a non-planar microfluidic device

2017 ◽  
Author(s):  
Cong Huang ◽  
Hong-Bo Zhang ◽  
Katharina K. C. Koch ◽  
Rui-Xue Yin ◽  
Wen-Jun Zhang
Keyword(s):  
Microfluidic Device ◽  
Double Emulsion ◽  
Oil In Water

scholarly journals Microencapsulation of Purple Cactus Pear Fruit (Opuntia ficus indica) Extract by the Combined Method W/O/W Double Emulsion-Spray Drying and Conventional Spray Drying: A Comparative Study

Processes ◽  
2018 ◽  
Vol 6 (10) ◽  
pp. 189 ◽  
Author(s):  
Keren Toledo-Madrid ◽  
Tzayhrí Gallardo-Velázquez ◽  
Guillermo Osorio-Revilla
Keyword(s):  
Spray Drying ◽  
Desirability Function ◽  
Double Emulsion ◽  
Dry Weight ◽  
Antioxidant Compounds ◽  
Pear Fruit ◽  
Cactus Pear ◽  
Opuntia Ficus Indica ◽  
Globule Size ◽  
Oil In Water

The aim of this study was to microencapsulate an optimized extract of purple cactus pear fruit (Opuntia ficus indica), rich in phenolic compounds (PC), betacyanins (BC), and betaxanthins (BX), with antioxidant capacity (AC), by two methodologies: combined water-in-oil-in water double emulsions-spray drying (W/O/W-SP) and conventional spray drying, studying the effect of spray drying (SP) on PC and AC. Optimal extraction conditions for bioactive compounds were: 52 °C, for 30 min, using aqueous ethanol (40%) as the solvent, with a 0.85 desirability function, obtaining 17.39 ± 0.11 mg GAE/gdw (gallic acid equivalents per gram of dry weight) for PC, 0.35 mg BE/gdw (betanin equivalents per gram of dry weight) for BC, and 0.26 mg IE/gdw (indicaxanthin equivalents per gram of dry weight) for BX. The best combination of temperatures for conventional SP and W/O/W-SP was 160–80 °C obtaining the highest retention and encapsulation efficiencies for PC. For conventional SP, results were: 107% and 100% PC and AC retention efficiencies (RE-PC and RE-AC), respectively, with 97% of PC encapsulation efficiency (EE-PC), meanwhile for the W/O/W-SP results were: 78% and 103% RE-PC and RE-AC, respectively, with 70% of EE-PC. Microcapsules obtained with W/O/W-SP maintained their structure and integrity and showed a considerable reduction in globule size in the reconstituted W/O/W emulsions due to the spray drying stress. Despite having lower EE-PC than conventional SP, spray dried W/O/W emulsions seems to be a promising controlled-delivery vehicle for antioxidant compounds.

scholarly journals Microfluidic Based Fabrication and Characterization of Highly Porous Polymeric Microspheres

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 419 ◽  
Author(s):  
Benzion Amoyav ◽  
Ofra Benny
Keyword(s):  
Tissue Engineering ◽  
Microfluidic Device ◽  
Polymer Concentration ◽  
Double Emulsion ◽  
Polymeric Microspheres ◽  
Porous Particles ◽  
Floating Drug Delivery ◽  
Porous Beads ◽  
Batch Formulation ◽  
New Applications

Polymeric porous particles are currently used for various applications in biotechnology, tissue engineering and pharmaceutical science, e.g., floating drug delivery systems and inhaled formulations. Particle shape and size depend on variable parameters; among them, polymer type and concentration, stirring speed, pH and type of solvent. In this study, porous poly(lactic-co-glycolic) acid (PLGA) and poly(d,l-lactide) (PLA) microspheres (MPs), with varying sizes and morphologies, were synthesized and optimized using both batch formulation and a flow-focusing microfluidic device. A well-established method of preparation utilizing solvent evaporation and the double emulsion technique was performed. Similar to other batch encapsulation methods, this technique is time and reagent consuming and consists of several steps. Hence, although porous structures provide tremendous opportunity in the design of new applications for tissue engineering and as improved controlled-release carriers, the synthesis of these particles with predefined properties remains challenging. We demonstrated the fabrication of porous MPs using a simple microfluidic device, compared to batch synthesis fabrication; and the effect of solvent, polymer concentration and type, post-hydrolysis treatment, on porosity degree. Moreover, a kinetic release study of fluorescent molecule was conducted for non-porous in comparison to porous particles. An overview of future prospects and the potential of these porous beads in this scientific area are discussed.

Modification of PDMS to fabricate PLGA microparticles by a double emulsion method in a single microfluidic device

Lab on a Chip ◽  
2016 ◽  
Vol 16 (14) ◽  
pp. 2596-2600 ◽  
Author(s):  
Leila Montazeri ◽  
Shahin Bonakdar ◽  
Mojtaba Taghipour ◽  
Philippe Renaud ◽  
Hossein Baharvand
Keyword(s):  
Microfluidic Device ◽  
Double Emulsion ◽  
Emulsion Method ◽  
Plga Microparticles

We present an easy, durable method to generate a partially hydrophilic/hydrophobic poly(dimethylsiloxane) (PDMS) microfluidic device.

A simple microfluidic device for fabrication of double emulsion droplets and polymer microcapsules

2012 ◽  
Vol 3 (4) ◽  
pp. 1043 ◽  
Author(s):  
Gabit Nurumbetov ◽  
Nicholas Ballard ◽  
Stefan A. F. Bon
Keyword(s):  
Microfluidic Device ◽  
Double Emulsion ◽  
Emulsion Droplets ◽  
Double Emulsion Droplets

Fabrication of Ofloxacin/PLGA Microsphere for Bone Tuberculosis Therapy

2013 ◽  
Vol 647 ◽  
pp. 176-180 ◽  
Author(s):  
Gang Wu ◽  
Long Chen ◽  
Chun Ling Deng ◽  
Kun Wei
Keyword(s):  
Double Emulsion ◽  
Distribution Analysis ◽  
Mesoporous Silicon ◽  
Water Solvent ◽  
Loading Efficiency ◽  
Internal Phase ◽  
Oil In Water ◽  
Phase Group ◽  
Bone Tuberculosis ◽  
Tuberculosis Therapy

The purpose of this research was to use mesoporous silicon (mpSi) as internal phase additive to improve the hydrophilic ofloxacin loaded by the hydrophobic PLGA materials through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Laser distribution analysis displayed low impact of MS additive on the final particles size. When compared to particle loading efficiency of none internal phase additives, MS internal phase group showed higher loading efficiency, and it increased with MS amounts inside the microparticles. All the burst releases of MS internal phase groups were severe than none MS group and was directly related the MS amount inside the microsphere. The release rate was increasing with the MS amounts added into the internal phase.

Internal Coalescence as a Mechanism of Instability in Water-in-Oil-in-Water Double-Emulsion Globules

Langmuir ◽  
2003 ◽  
Vol 19 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Carlos H. Villa ◽  
Louise B. Lawson ◽  
Yimin Li ◽  
Kyriakos D. Papadopoulos
Keyword(s):  
Double Emulsion ◽  
Oil In Water
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