Investigation of prefrontal cerebral hemodynamics during quantitative autonomic testing using NIRS (Conference Presentation)

Author(s):  
Zephaniah Phillips ◽  
Seung-ho Paik ◽  
Yoohwan Kim ◽  
Byung-Jo Kim ◽  
Youngwoon Choi ◽  
...  
2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
H Zotter ◽  
B Urlesberger ◽  
R Kerbl ◽  
G Pichler ◽  
W Müller

1991 ◽  
Vol 17 (3-4) ◽  
pp. 128-132 ◽  
Author(s):  
Heike Rabe ◽  
Gerhard Jorch

Hypertension ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 712-720 ◽  
Author(s):  
Chang-Yang Xing ◽  
Takashi Tarumi ◽  
Rutger L. Meijers ◽  
Marcel Turner ◽  
Justin Repshas ◽  
...  

Author(s):  
Heidrun H. Krämer ◽  
Cora Rebhorn ◽  
Christian Geber ◽  
Frank Birklein

Abstract Objective To explore small fiber somatosensory and sympathetic function in PD and MSA. Methods We recruited 20 PD patients (7 women, median age 65.5 years; IQR 54.75–70.0), 10 MSA patients (4 women; median age 68 years; IQR 66.25–74.0), and 10 healthy subjects (HC; 4 women, median age 68; IQR 59.0–71.0 years). Autonomic testing included forehead cooling, intradermal microdialysis of norepinephrine (NE; 10–5; 10–6; 10–7; and 10–8), and orthostatic hypotension (OH); somatosensory testing included quantitative sensory testing (QST) according to the protocol of the German Research Network on Neuropathic Pain (DFNS). Results OH occurred more frequently in PD (p = 0.018) and MSA (p = 0.002) compared to HC. Vasoconstriction responses were stronger in PD compared to MSA during forehead cooling (p = 0.044) and microdialysis of physiologically concentrated NE solutions (10–7; 10–8; p = 0.017). PD and MSA had impaired cold (PD: p < 0.01; MSA: p < 0.05) and warm detection thresholds (PD and MSA, both p < 0.05). The mechanical detection threshold was higher in PD (p < 0.01). Conversely, mechanical pain thresholds were decreased in PD and MSA (both p < 0.001), indicating mechanical hyperalgesia. Conclusion In contrast to MSA, we found evidence of peripheral adrenoreceptor hypersensitivity in PD, probably caused by peripheral sympathetic denervation. Sensory testing revealed peripheral neuropathy and central pain sensitization in PD and MSA. Jointly, our data demonstrate autonomic and somatosensory dysfunction in PD and MSA.


2010 ◽  
Vol 21 (2) ◽  
pp. 432-435 ◽  
Author(s):  
Bingyu Wang ◽  
Zhihua Cheng ◽  
Xiongzheng Mu ◽  
Baohua Fan ◽  
Zhilin Guo

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