Mueller-matrix mapping of optically anisotropic fluorophores of molecular biological tissues in the diagnosis of death causes

2016 ◽  
Author(s):  
A. G. Ushenko ◽  
A. V. Dubolazov ◽  
V. A. Ushenko ◽  
Yu. A. Ushenko ◽  
L. Y. Pidkamin ◽  
...  
Keyword(s):  
Biological Tissues ◽  
Mueller Matrix ◽  
Matrix Mapping ◽  
Death Causes ◽  
Diagnosis Of Death

Mueller-matrix mapping of biological tissues in differential diagnosis of optical anisotropy mechanisms of protein networks

2015 ◽  
Vol 45 (3) ◽  
pp. 265-269 ◽  
Author(s):  
V A Ushenko ◽  
M I Sidor ◽  
Yu F Marchuk ◽  
N V Pashkovskaya ◽  
D R Andreichuk
Keyword(s):  
Differential Diagnosis ◽  
Optical Anisotropy ◽  
Biological Tissues ◽  
Mueller Matrix ◽  
Protein Networks ◽  
Matrix Mapping

scholarly journals Differential Mueller matrix imaging of partially depolarizing optically anisotropic biological tissues

2019 ◽  
Vol 35 (4) ◽  
pp. 877-891 ◽  
Author(s):  
L. Trifonyuk ◽  
A. Sdobnov ◽  
W. Baranowski ◽  
V. Ushenko ◽  
O. Olar ◽  
...  
Keyword(s):  
Biological Tissues ◽  
Mueller Matrix ◽  
Differential Diagnostics ◽  
Matrix Elements ◽  
Polycrystalline Structure ◽  
First Order ◽  
Histological Sections ◽  
Laser Polarimetry ◽  
Matrix Mapping ◽  
Differential Matrix

AbstractSince recently, a number of innovative polarization-based optical imaging modalities have been introduced and extensively used in various biomedical applications, with an ultimate aim to attain the practical tool for the optical biopsy and functional characterization of biological tissues. The techniques utilize polarization properties of light and Mueller matrix mapping of microscopic images of histological sections of biological tissues or polycrystalline films of biological fluids. The main drawback of currently developed laser polarimetry approaches and Mueller matrix mapping techniques is poor reproducibility of experimental data. This is due to azimuthal dependence of polarization and ellipticity values of most matrix elements to sample orientation in respect to incidence light polarization. Current study aims to generalize the methods of laser polarimetry for diagnosis of partially depolarizing optically anisotropic biological tissues. A method of differential Mueller matrix mapping for reconstruction of linear and circular birefringence and dichroism parameter distributions of partially depolarizing layers of biological tissues of different morphological structure is introduced and practically implemented. The coordinate distributions of the value of the first-order differential matrix elements of histological sections of brain tissue with spatially structured, optically anisotropic fibrillar network, as well as of parenchymatous tissue of the rectum wall with an “islet” polycrystalline structure are determined. Within the statistical analysis of polarization reproduced distributions of the averaged parameters of phase and amplitude anisotropy, the significant sensitivity of the statistical moments of the third and fourth orders to changes in the polycrystalline structure of partially depolarizing layers of biological tissue is observed. The differentiation of female reproductive sphere connective tissue is realized with excellent accuracy. The differential Mueller matrix mapping method for reconstruction of distributions of linear and circular birefringence and dichroism parameters of partially depolarizing layers of biological tissues of different morphological structures is proposed and substantiated. Differential diagnostics of changes in the phase (good balanced accuracy) and amplitude (excellent balanced accuracy) of the anisotropy of the partially depolarizing layers of the vagina wall tissue with prolapse of the genitals is realized. The maximum diagnostic efficiency of the first-order differential matrix method was demonstrated in comparison with the traditional methods of polarization and Mueller matrix mapping of histological sections of light-scattering biological tissues.

System of differential Mueller-matrix mapping of phase and amplitude anisotropy of depolarizing biological tissues

2018 ◽  
Author(s):  
M. I. Sidor ◽  
Olexander V. Dubolazov ◽  
Yuriy Ushenko ◽  
O. V. Olar ◽  
O. B. Bodnar ◽  
...  
Keyword(s):  
Biological Tissues ◽  
Mueller Matrix ◽  
Amplitude Anisotropy ◽  
Matrix Mapping

Azimuth-invariant mueller-matrix differentiation of the optical anisotropy of biological tissues

2014 ◽  
Vol 117 (1) ◽  
pp. 152-157 ◽  
Author(s):  
V. A. Ushenko ◽  
M. I. Sidor ◽  
Yu. F. Marchuk ◽  
N. V. Pashkovskaya ◽  
D. R. Andreichuk
Keyword(s):  
Optical Anisotropy ◽  
Biological Tissues ◽  
Mueller Matrix

scholarly journals Polarization-Singular Approach to Imaging Mueller-Matrix Polarimetry in the Differential Diagnosis of Histological Sections of Biopsy of Tumors of the Uterus and Prostate

2021 ◽  
Vol 9 ◽  
Author(s):  
A. Dubolazov ◽  
V. Ushenko ◽  
L. Trifonyuk ◽  
A. Stashkevich ◽  
I. Soltys ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mueller Matrix ◽  
Evidence Based ◽  
Malignant Tumours ◽  
Diagnostic Use ◽  
Matrix Mapping ◽  
Adenocarcinoma Of The Prostate ◽  
Characteristic Values ◽  
Sensitivity Specificity ◽  
Based Medicine

The possibilities of the diagnostic use of the singular approach of the distributions of the number of characteristic values of the MMI is effective for differentiating the polarization properties of histological biopsy sections of benign and malignant tumours of the uterus and prostate. Within the framework of evidence-based medicine, the sensitivity, specificity and accuracy of the azimuthal-invariant express (∼15 min) method of Mueller-matrix mapping of polarization-singular states in the differential diagnosis of uterine myoma and adenocarcinoma, as well as adenocarcinoma of the prostate with varying degrees of differentiation have been determined.

scholarly journals Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters

2014 ◽  
Vol 5 (12) ◽  
pp. 4223 ◽  
Author(s):  
Minghao Sun ◽  
Honghui He ◽  
Nan Zeng ◽  
E Du ◽  
Yihong Guo ◽  
...  
Keyword(s):  
Biological Tissues ◽  
Mueller Matrix
Sign in / Sign up

Export Citation Format

Share Document