Physico-chemical and biochemical approaches to assessing the development of precancerous pathologies of the gastrointestinal tract during their modeling in mice with complex effects of stress factors of different nature

2016 ◽  
Author(s):  
Zamira O. Alieva ◽  
Matvej V. Kanevskiy ◽  
Anna A. Galitskaya ◽  
Irina K. Mironova ◽  
Ekaterina V. Pleshakova ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Stress Factors ◽  
Physico Chemical ◽  
Effects Of Stress

Physico-chemical parameters of the best varieties of peach in the subtropics of Russia

2021 ◽  
Author(s):  
Yu.S. Abilfazova ◽  
Keyword(s):  
Scientific Research ◽  
Stress Factors ◽  
Research Center ◽  
Chemical Parameters ◽  
Subtropical Zone ◽  
Russian Academy Of Sciences ◽  
Federal Research ◽  
Physico Chemical ◽  
Resistance To Stress ◽  
Academy Of Sciences

the characteristic the best varieties peach plants cultivated in the subtropical zone Krasnodar Territory is given. The study collection plantations peach in the subtropical zone Krasnodar Territory has been carried out since 2009 at the Federal Research Center Scientific Research Center of the Russian Academy of Sciences. The results of many years of research have identified the best peach varieties (Redhaven, Favorita Morettini, Larisa, Medin red, Veteran, Fayet), distinguished by resistance to stress factors and high palatability of the fruits.

An overview of Natural Superdisintegrants

2021 ◽  
pp. 113-124
Author(s):  
Shushank Sharma
Keyword(s):  
Gastrointestinal Tract ◽  
Aqueous Media ◽  
Chemical Properties ◽  
Cost Effective ◽  
Oral Route ◽  
Drug Formulation ◽  
Release Time ◽  
Disintegration Time ◽  
Physico Chemical ◽  
Set Up

The oral route is the most convenient route of administration for various drugs. It is viewed as the most convenient, most secure, and economical route for patients. Fast disintegrating tablets are popular these days as they disintegrate in the mouth within a few seconds without the use of water. The burdens of regularly used medications in pediatric and geriatric patients have been overwhelmed by quick-dissolving tablets. Natural superdisintegrants have been used for fast-dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable, and generally accessible. Natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Natural super disintegrants decrease the release time and give healthful results to the patients. Most polymers are obtained from nature, they are cost-effective, non-toxic, and non-irritants. Disintegration is the most important step for releasing the drug from the tablet matrix to decrease the disintegration time. In this, drug and polymers come in contact with water, it swells, hydrate, and react chemically to release the drug in the mouth and gastrointestinal tract. Superdisintegrants are those substances that encourage the quick breaking down with a lesser amount contrasted with disintegrants. The quick disintegrants tablets are set up by utilizing suitable polymers which rely on the Physico-chemical properties of drugs and excipients, for example, drug and polymer compatibility, hardness and thickness of tablet, nature of drug and excipients, PH of drug and release parameters of drug formulation. Superdisintegrants are the vehicles added to tablet formulation to advance the breaking of tablets and capsules into small microparticles in aqueous media resulting in to increase in the surface area and promote quick drug release. The disintegrants have a significant capacity to oppose the efficacy of tablet binders and compression forces to form the tablet. Commonly there are three methods to incorporate disintegrants into the tablet: A. Inner addition, B. External expansion, C. Internal, and external addition. Most of the regularly based tablets are those expected to be swallow, disintegrate and release medicaments in the gastrointestinal tract but over a while tablets are manufactured to deliver medicaments in the mouth and gastrointestinal tract within few seconds of swallowing. It has been demonstrated that characteristic polymers are more effective than synthetic polymers. Some research is going to develop safe and effective medication with super disintegrating agents that can be dissolved rapidly to treat the disease.

The first trimeric Galanthus nivalis agglutinin-related lectin of Orchidaceae was found in Dendrobium pendulum: purification, characterization, and effects of stress factors

2015 ◽  
Vol 34 (7) ◽  
pp. 1253-1262 ◽  
Author(s):  
Patthraporn Siripipatthana ◽  
Narumon Phaonakrop ◽  
Sittiruk Roytrakul ◽  
Gulsiri Senawong ◽  
Rasika G. Mudalige-Jayawickrama ◽  
...  
Keyword(s):  
Stress Factors ◽  
Galanthus Nivalis Agglutinin ◽  
Galanthus Nivalis ◽  
Effects Of Stress ◽  
Dendrobium Pendulum

The Effects of Stress Factors on the Growth of Spoilage Yeasts Isolated From Apple-Related Environments in Apple Juice

2015 ◽  
Vol 36 (2) ◽  
pp. 162-171 ◽  
Author(s):  
Huxuan Wang ◽  
Zhongqiu Hu ◽  
Fangyu Long ◽  
Chunfeng Guo ◽  
Chen Niu ◽  
...  
Keyword(s):  
Apple Juice ◽  
Stress Factors ◽  
Spoilage Yeasts ◽  
Effects Of Stress

Differential response of Pichia guilliermondii spoilage isolates to biological and physico-chemical factors prevailing in Patagonian wine fermentations

2009 ◽  
Vol 55 (7) ◽  
pp. 801-809 ◽  
Author(s):  
Christian A. Lopes ◽  
Julieta S. Sáez ◽  
Marcela P. Sangorrín
Keyword(s):  
Maximum Level ◽  
Pichia Anomala ◽  
Stress Factors ◽  
Response Patterns ◽  
Pichia Guilliermondii ◽  
Volatile Phenols ◽  
Principal Coordinates Analysis ◽  
Killer Yeasts ◽  
Principal Coordinates ◽  
Physico Chemical

Pichia guilliermondii can produce volatile phenols in the initial stages of wine fermentation; however, its response to different wine stress conditions has been poorly studied. In this work, we present an analysis of the response of 23 P. guilliermondii indigenous isolates to physical and chemical wine stress factors and to indigenous wine killer yeasts. Principal coordinates analysis (PCoA), based on data obtained from response patterns, was carried out to evaluate the relationships among the isolates. Major differences among the isolates were detected in media plates containing 8% ethanol and in those containing 280 g/L glucose. PCoA identified 3 clusters of isolates with different stress response patterns, indicating a relationship between the tolerance to these compounds and the origin of the isolates. Pichia guilliermondii isolates were sensitive to the toxins produced by the species Hanseniaspora uvarum , Metschnikowia pulcherrima , Wickerhamomyces anomala (ex Pichia anomala ), and Pichia kluyveri , with a maximum level of sensitivity against W. anomala (91% on average). Those isolates obtained from fermenting must proved to be more resistant to killer yeasts than those obtained from grape surfaces. The combined evaluation of the response to physico-chemical and biological factors presented in this work could be a useful standard protocol for the evaluation of the potential spoilage capacity of yeasts in winemaking.

A review: An overview of Natural Superdisintegrants

2021 ◽  
pp. 13-24
Author(s):  
Shushank Sharma ◽  
Sikha Chauhan
Keyword(s):  
Gastrointestinal Tract ◽  
Aqueous Media ◽  
Chemical Properties ◽  
Cost Effective ◽  
Oral Route ◽  
Drug Formulation ◽  
Release Time ◽  
Disintegration Time ◽  
Physico Chemical ◽  
Set Up

The oral route is the most convenient route of administration for various drugs. It is viewed as the most convenient, most secure, and economical route for patients. Fast disintegrating tablets are popular these days as they disintegrate in the mouth within a few seconds without the use of water. The burdens of regularly used medications in pediatric and geriatric patients have been overwhelmed by quick-dissolving tablets. Natural superdisintegrants have been used for fast-dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable, and generally accessible. Natural polymer improves the properties of the tablet as it is commonly used as diluents and binders. Natural super disintegrants decrease the release time and give healthful results to the patients. Most polymers are obtained from nature, they are cost-effective, non-toxic, and non-irritants. Disintegration is the most important step for releasing the drug from the tablet matrix to decrease the disintegration time. In this, drug and polymers come in contact with water, it swells, hydrate, and react chemically to release the drug in the mouth and gastrointestinal tract. Superdisintegrants are those substances that encourage the quick breaking down with a lesser amount contrasted with disintegrants. The quick disintegrants tablets are set up by utilizing suitable polymers which rely on the Physico-Chemical properties of drugs and excipients, for example, drug and polymer compatibility, hardness and thickness of tablet, nature of drug and excipients, PH of drug and release parameters of drug formulation. Superdisintegrants are the vehicles added to tablet formulation to advance the breaking of tablets and capsules into small microparticles in aqueous media resulting in to increase in the surface area and promote quick drug release. The disintegrants have a significant capacity to oppose the efficacy of tablet binders and compression forces to form the tablet. Commonly there are three methods to incorporate disintegrants into the tablet: A. Inner addition, B. External expansion, C. Internal, and external addition. Most of the regularly based tablets are those expected to be swallow, disintegrate and release medicaments in the gastrointestinal tract but over a while tablets are manufactured to deliver medicaments in the mouth and gastrointestinal tract within few seconds of swallowing. It has been demonstrated that characteristic polymers are more effective than synthetic polymers. Some research is going to develop safe and effective medication with super disintegrating agents that can be dissolved rapidly to treat the disease.

Signalling from the gut lumen

2017 ◽  
Vol 57 (11) ◽  
pp. 2175 ◽  
Author(s):  
John B. Furness ◽  
Jeremy J. Cottrell
Keyword(s):  
Nervous System ◽  
Gastrointestinal Tract ◽  
Pathogen Detection ◽  
Chemical Properties ◽  
Endocrine System ◽  
Enteroendocrine Cells ◽  
Local Tissue ◽  
Physico Chemical ◽  
Specific Receptors ◽  
Free Fatty Acid Receptors

The lining of the gastrointestinal tract needs to be easily accessible to nutrients and, at the same time, defend against pathogens and chemical challenges. This lining is the largest and most vulnerable surface that faces the outside world. To manage the dual problems of effective nutrient conversion and defence, the gut lining has a sophisticated system for detection of individual chemical entities, pathogenic organisms and their products, and physico-chemical properties of its contents. Detection is through specific receptors that signal to the gut endocrine system, the nervous system, the immune system and local tissue defence systems. These effectors, in turn, modify digestive functions and contribute to tissue defence. Receptors for nutrients include taste receptors for sweet, bitter and savoury, free fatty acid receptors, peptide and phytochemical receptors, that are primarily located on enteroendocrine cells. Hormones released by enteroendocrine cells act locally, through the circulation and via the nervous system, to optimise digestion and mucosal health. Pathogen detection is both through antigen presentation to T-cells and through pattern-recognition receptors (PRRs). Activation of PRRs triggers local tissue defence, for example, by causing release of antimicrobials from Paneth cells. Toxic chemicals, including plant toxins, are sensed and then avoided, expelled or metabolised. It continues to be a major challenge to develop a comprehensive understanding of the integrated responses of the gastrointestinal tract to its luminal contents.

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