Optical surgical navigation for nodal staging: to see or not to see?

2016 ◽  
Author(s):  
Eva M. Sevick-Muraca ◽  
Barrett R. Harvey ◽  
John C. Rasmussen ◽  
Banghe Zhu
Keyword(s):  
Surgical Navigation ◽  
Nodal Staging ◽  
Optical Surgical Navigation

scholarly journals Novel Peptide NIRF Optical Surgical Navigation Agents for HNSCC

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3070 ◽  
Author(s):  
Haiming Ding ◽  
Shankaran Kothandaraman ◽  
Li Gong ◽  
Chadwick L. Wright ◽  
Quintin Pan ◽  
...  
Keyword(s):  
Surgical Navigation ◽  
Survival Rates ◽  
Uptake Kinetics ◽  
Cell Uptake ◽  
Cell Binding ◽  
Promising Candidate ◽  
Optical Surgical Navigation ◽  
Structural Variables ◽  
Xenograft Mice ◽  
Background Contrast

Head and neck squamous cell carcinoma (HNSCC) survival rates have not improved in a decade, with a 63% 5-year recurrence rate after surgery, making HNSCC a compelling indication for optical surgical navigation (OSN). A promising peptide, HN1, targeted and internalized in human HNSCC cells in multiple laboratories, but was slow (24 h) to accumulate. We modified HN1 and explored structural variables to improve the uptake kinetics and create IRdye800 adducts useful for OSN. Eleven new molecules were synthesized and characterized chemically, in human HNSCC cells (Cal 27), and in HNSCC xenograft mice. Cal 27 flank xenografts in Balb/c nude mice were imaged for 3–48 h after 40 nmol intravenous doses of IR800-labeled molecules. Cell uptake kinetics in the 1–2 h window incubated at 1–10 μM were independent of the dye label (FITC, Cy5, or IR800), but increased markedly with additional N-terminal lipophilic substitution, and after resequencing the peptide to separate polar amino acids and move the lysine-dye more centrally. Microscopy confirmed the strong Cal 27 cell binding and demonstrated primarily cytosolic and membrane localization of the fastest peptide, 4Iphf-HN17. 4Iph-HN17-IR800 showed 26-fold greater rate of uptake in cells than HN1-IR800, and far stronger OSN imaging intensity and tumor to background contrast in mice, suggesting that the new peptide is a promising candidate for OSN of HNSCC.

scholarly journals Optical Surgical Navigation for Precision in Tumor Resections

2017 ◽  
Vol 19 (3) ◽  
pp. 357-362 ◽  
Author(s):  
Stefan Harmsen ◽  
Nutte Teraphongphom ◽  
Michael F. Tweedle ◽  
James P. Basilion ◽  
Eben L. Rosenthal
Keyword(s):  
Surgical Navigation ◽  
Optical Surgical Navigation

scholarly journals Effects of an Unlabeled Loading Dose on Tumor-Specific Uptake of a Fluorescently Labeled Antibody for Optical Surgical Navigation

2016 ◽  
Vol 19 (4) ◽  
pp. 610-616 ◽  
Author(s):  
Lindsay S. Moore ◽  
Eben L. Rosenthal ◽  
Esther de Boer ◽  
Andrew C. Prince ◽  
Neel Patel ◽  
...  
Keyword(s):  
Surgical Navigation ◽  
Loading Dose ◽  
Optical Surgical Navigation ◽  
Specific Uptake

Real-time automatic registration in optical surgical navigation

2016 ◽  
Vol 76 ◽  
pp. 375-385 ◽  
Author(s):  
Qinyong Lin ◽  
Rongqian Yang ◽  
Ken Cai ◽  
Xuan Si ◽  
Xiuwen Chen ◽  
...  
Keyword(s):  
Real Time ◽  
Surgical Navigation ◽  
Automatic Registration ◽  
Optical Surgical Navigation

scholarly journals Sialendoscopy and CT navigation assistance in the surgery of sialolithiasis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleksandar Anicin ◽  
Jure Urbancic
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Computer Tomography ◽  
Surgical Navigation ◽  
Diagnostic Procedures ◽  
Combined Approach ◽  
Tertiary Institution ◽  
Navigation Assistance ◽  
Optical Surgical Navigation ◽  
Salivary Gland Disease

Abstract Background A sialendoscopy-assisted combined approach is well established in the surgery of sialolithiasis. In cases of proximal salivary stones, transcutaneous sialendoscopy-assisted extractions with parotid and submandibular gland preservation is the primary intention of treatment. We recently added computer tomography (CT) navigation to improve the results of this challenging surgery equally in both localizations. Patients and methods Al l the patients who submitted to sialendoscopy and sialendoscopy-assisted procedures at the tertiary institution between January 2012 and October 2020 were included in the present study. From November 2019, CT navigation was added in cases with sialolithiasis and a presumably poor sialendoscopic visibility. We evaluated the parameters of the disease, diagnostic procedures, sialendoscopic findings and outcomes, with or without optical surgical navigation. Results We performed 178 successful salivary stone removals in 372 patients, of which 118 were combined sialendos-copy-assisted approaches, including 16 transcutaneous proximal, 10 submandibular and 6 parotid stone operations. Surgical navigation was used in six patients, four times for submandibular and twice for parotid sialolithiasis. These were all non-palpable, sialendoscopically invisible or partially visible stones, and we managed to preserve five of the six salivary glands. Conclusions The addition of CT navigation to sialendoscopy-assisted procedures for non-palpable, sialendoscopically invisible and fixed stones is a significant advantage in managing sialolithiasis. By consistently performing sialendoscopy and related preservation procedures, we significantly reduced the need for sialoadenectomies in patients with obstructive salivary gland disease.

Simulation and Visualization of Liver Cancer Ablation Focus in Optical Surgical Navigation

2015 ◽  
Vol 40 (1) ◽  
Author(s):  
Ken Cai ◽  
Rongqian Yang ◽  
Huazhou Chen ◽  
Hai Ning ◽  
Amin Ma ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Surgical Navigation ◽  
Optical Surgical Navigation ◽  
Cancer Ablation

Geometric calibration of markerless optical surgical navigation system

2019 ◽  
Vol 15 (2) ◽  
pp. e1978 ◽  
Author(s):  
Qinyong Lin ◽  
Ken Cai ◽  
Rongqian Yang ◽  
Weihu Xiao ◽  
Jinhua Huang ◽  
...  
Keyword(s):  
Navigation System ◽  
Surgical Navigation ◽  
Geometric Calibration ◽  
Surgical Navigation System ◽  
Optical Surgical Navigation

scholarly journals Optical surgical navigation system causes pulse oximeter malfunction

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
Masaaki Satoh ◽  
Tetsuhito Hara ◽  
Kenji Tamai ◽  
Juntaro Shiba ◽  
Kunihisa Hotta ◽  
...  
Keyword(s):  
Navigation System ◽  
Pulse Oximeter ◽  
Surgical Navigation ◽  
Surgical Navigation System ◽  
Optical Surgical Navigation
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