Phantom-less bone mineral density (BMD) measurement using dual energy computed tomography-based 3-material decomposition

2016 ◽  
Author(s):  
Philipp Hofmann ◽  
Martin Sedlmair ◽  
Bernhard Krauss ◽  
Julian L. Wichmann ◽  
Ralf W. Bauer ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Dual Energy ◽  
Material Decomposition ◽  
Mineral Density ◽  
Dual Energy Computed Tomography

scholarly journals Use of dual-energy computed tomography to measure skeletal-wide marrow composition and cancellous bone mineral density

2016 ◽  
Vol 35 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Luke Arentsen ◽  
Karen E. Hansen ◽  
Masashi Yagi ◽  
Yutaka Takahashi ◽  
Ryan Shanley ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Cancellous Bone ◽  
Dual Energy ◽  
Mineral Density ◽  
Dual Energy Computed Tomography

scholarly journals Diagnostic accuracy of quantitative dual-energy CT-based volumetric bone mineral density assessment for the prediction of osteoporosis-associated fractures

2021 ◽  
Author(s):  
Leon D. Gruenewald ◽  
Vitali Koch ◽  
Simon S. Martin ◽  
Ibrahim Yel ◽  
Katrin Eichler ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
At Risk ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Volumetric Bone Mineral Density ◽  
Material Decomposition ◽  
Mineral Density ◽  
Risk Patients

Abstract Objectives To evaluate the predictive value of volumetric bone mineral density (BMD) assessment of the lumbar spine derived from phantomless dual-energy CT (DECT)-based volumetric material decomposition as an indicator for the 2-year occurrence risk of osteoporosis-associated fractures. Methods L1 of 92 patients (46 men, 46 women; mean age, 64 years, range, 19–103 years) who had undergone third-generation dual-source DECT between 01/2016 and 12/2018 was retrospectively analyzed. For phantomless BMD assessment, dedicated DECT postprocessing software using material decomposition was applied. Digital files of all patients were sighted for 2 years following DECT to obtain the incidence of osteoporotic fractures. Receiver operating characteristic (ROC) analysis was used to calculate cut-off values and logistic regression models were used to determine associations of BMD, sex, and age with the occurrence of osteoporotic fractures. Results A DECT-derived BMD cut-off of 93.70 mg/cm3 yielded 85.45% sensitivity and 89.19% specificity for the prediction to sustain one or more osteoporosis-associated fractures within 2 years after BMD measurement. DECT-derived BMD was significantly associated with the occurrence of new fractures (odds ratio of 0.8710, 95% CI, 0.091–0.9375, p < .001), indicating a protective effect of increased DECT-derived BMD values. Overall AUC was 0.9373 (CI, 0.867–0.977, p < .001) for the differentiation of patients who sustained osteoporosis-associated fractures within 2 years of BMD assessment. Conclusions Retrospective DECT-based volumetric BMD assessment can accurately predict the 2-year risk to sustain an osteoporosis-associated fracture in at-risk patients without requiring a calibration phantom. Lower DECT-based BMD values are strongly associated with an increased risk to sustain fragility fractures. Key Points •Dual-energy CT–derived assessment of bone mineral density can identify patients at risk to sustain osteoporosis-associated fractures with a sensitivity of 85.45% and a specificity of 89.19%. •The DECT-derived BMD threshold for identification of at-risk patients lies above the American College of Radiology (ACR) QCT guidelines for the identification of osteoporosis (93.70 mg/cm3 vs 80 mg/cm3).

scholarly journals Modern approaches and possibilities for assessing bone mineral density by quantitative computed tomography (literature review)

2021 ◽  
Vol 23 (4) ◽  
pp. 372-381
Author(s):  
Aleksandr A. Melnikov ◽  
◽  
Viktor V. Diachenko ◽  
Igor V. Shubin ◽  
Aleksei E. Nikitin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Dual Energy ◽  
Mineral Density ◽  
Diagnosis Of Osteoporosis ◽  
X Ray ◽  
Clinically Significant

The review provides the literature data on the basal issues of bone remodeling and the applied use of medical imaging techniques for the prevention of clinically significant consequences of osteoporosis. The article discusses the role and prospects of using the method of quantitative computed tomography and its modifications for the diagnosis of osteoporosis and osteopenic syndrome. It considers the advantages of quantitative computed tomography over widely used medical techniques for assessing bone mineral density (mono- and dual-energy X-ray absorptiometry, mono- and dual-energy isotope absorptiometry).

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