Phantom-based ground-truth generation for cerebral vessel segmentation and pulsatile deformation analysis

Author(s):  
Daniel Schetelig ◽  
Dennis Säring ◽  
Till Illies ◽  
Jan Sedlacik ◽  
Fabian Kording ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Orhun Utku Aydin ◽  
Abdel Aziz Taha ◽  
Adam Hilbert ◽  
Ahmed A. Khalil ◽  
Ivana Galinovic ◽  
...  

Abstract Background Arterial brain vessel segmentation allows utilising clinically relevant information contained within the cerebral vascular tree. Currently, however, no standardised performance measure is available to evaluate the quality of cerebral vessel segmentations. Thus, we developed a performance measure selection framework based on manual visual scoring of simulated segmentation variations to find the most suitable measure for cerebral vessel segmentation. Methods To simulate segmentation variations, we manually created non-overlapping segmentation errors common in magnetic resonance angiography cerebral vessel segmentation. In 10 patients, we generated a set of approximately 300 simulated segmentation variations for each ground truth image. Each segmentation was visually scored based on a predefined scoring system and segmentations were ranked based on 22 performance measures common in the literature. The correlation of visual scores with performance measure rankings was calculated using the Spearman correlation coefficient. Results The distance-based performance measures balanced average Hausdorff distance (rank = 1) and average Hausdorff distance (rank = 2) provided the segmentation rankings with the highest average correlation with manual rankings. They were followed by overlap-based measures such as Dice coefficient (rank = 7), a standard performance measure in medical image segmentation. Conclusions Average Hausdorff distance-based measures should be used as a standard performance measure in evaluating cerebral vessel segmentation quality. They can identify more relevant segmentation errors, especially in high-quality segmentations. Our findings have the potential to accelerate the validation and development of novel vessel segmentation approaches.


2021 ◽  
Vol 15 ◽  
Author(s):  
Heping Chen ◽  
Yan Shi ◽  
Bin Bo ◽  
Denghui Zhao ◽  
Peng Miao ◽  
...  

Laser speckle contrast imaging (LSCI) is a full-field, high spatiotemporal resolution and low-cost optical technique for measuring blood flow, which has been successfully used for neurovascular imaging. However, due to the low signal–noise ratio and the relatively small sizes, segmenting the cerebral vessels in LSCI has always been a technical challenge. Recently, deep learning has shown its advantages in vascular segmentation. Nonetheless, ground truth by manual labeling is usually required for training the network, which makes it difficult to implement in practice. In this manuscript, we proposed a deep learning-based method for real-time cerebral vessel segmentation of LSCI without ground truth labels, which could be further integrated into intraoperative blood vessel imaging system. Synthetic LSCI images were obtained with a synthesis network from LSCI images and public labeled dataset of Digital Retinal Images for Vessel Extraction, which were then used to train the segmentation network. Using matching strategies to reduce the size discrepancy between retinal images and laser speckle contrast images, we could further significantly improve image synthesis and segmentation performance. In the testing LSCI images of rodent cerebral vessels, the proposed method resulted in a dice similarity coefficient of over 75%.


2021 ◽  
Vol 7 (2) ◽  
pp. 21
Author(s):  
Roland Perko ◽  
Manfred Klopschitz ◽  
Alexander Almer ◽  
Peter M. Roth

Many scientific studies deal with person counting and density estimation from single images. Recently, convolutional neural networks (CNNs) have been applied for these tasks. Even though often better results are reported, it is often not clear where the improvements are resulting from, and if the proposed approaches would generalize. Thus, the main goal of this paper was to identify the critical aspects of these tasks and to show how these limit state-of-the-art approaches. Based on these findings, we show how to mitigate these limitations. To this end, we implemented a CNN-based baseline approach, which we extended to deal with identified problems. These include the discovery of bias in the reference data sets, ambiguity in ground truth generation, and mismatching of evaluation metrics w.r.t. the training loss function. The experimental results show that our modifications allow for significantly outperforming the baseline in terms of the accuracy of person counts and density estimation. In this way, we get a deeper understanding of CNN-based person density estimation beyond the network architecture. Furthermore, our insights would allow to advance the field of person density estimation in general by highlighting current limitations in the evaluation protocols.


2019 ◽  
Vol 53 (1) ◽  
pp. 38-39
Author(s):  
Anjie Fang

Recently, political events, such as elections, have raised a lot of discussions on social media networks, in particular, Twitter. This brings new opportunities for social scientists to address social science tasks, such as understanding what communities said or identifying whether a community has an influence on another. However, identifying these communities and extracting what they said from social media data are challenging and non-trivial tasks. We aim to make progress towards understanding 'who' (i.e. communities) said 'what' (i.e. discussed topics) and 'when' (i.e. time) during political events on Twitter. While identifying the 'who' can benefit from Twitter user community classification approaches, 'what' they said and 'when' can be effectively addressed on Twitter by extracting their discussed topics using topic modelling approaches that also account for the importance of time on Twitter. To evaluate the quality of these topics, it is necessary to investigate how coherent these topics are to humans. Accordingly, we propose a series of approaches in this thesis. First, we investigate how to effectively evaluate the coherence of the topics generated using a topic modelling approach. The topic coherence metric evaluates the topical coherence by examining the semantic similarity among words in a topic. We argue that the semantic similarity of words in tweets can be effectively captured by using word embeddings trained using a Twitter background dataset. Through a user study, we demonstrate that our proposed word embedding-based topic coherence metric can assess the coherence of topics like humans [1, 2]. In addition, inspired by the precision at k metric, we propose to evaluate the coherence of a topic model (containing many topics) by averaging the top-ranked topics within the topic model [3]. Our proposed metrics can not only evaluate the coherence of topics and topic models, but also can help users to choose the most coherent topics. Second, we aim to extract topics with a high coherence from Twitter data. Such topics can be easily interpreted by humans and they can assist to examine 'what' has been discussed and 'when'. Indeed, we argue that topics can be discussed in different time periods (see [4]) and therefore can be effectively identified and distinguished by considering their time periods. Hence, we propose an effective time-sensitive topic modelling approach by integrating the time dimension of tweets (i.e. 'when') [5]. We show that the time dimension helps to generate topics with a high coherence. Hence, we argue that 'what' has been discussed and 'when' can be effectively addressed by our proposed time-sensitive topic modelling approach. Next, to identify 'who' participated in the topic discussions, we propose approaches to identify the community affiliations of Twitter users, including automatic ground-truth generation approaches and a user community classification approach. We show that the mentioned hashtags and entities in the users' tweets can indicate which community a Twitter user belongs to. Hence, we argue that they can be used to generate the ground-truth data for classifying users into communities. On the other hand, we argue that different communities favour different topic discussions and their community affiliations can be identified by leveraging the discussed topics. Accordingly, we propose a Topic-Based Naive Bayes (TBNB) classification approach to classify Twitter users based on their words and discussed topics [6]. We demonstrate that our TBNB classifier together with the ground-truth generation approaches can effectively identify the community affiliations of Twitter users. Finally, to show the generalisation of our approaches, we apply our approaches to analyse 3.6 million tweets related to US Election 2016 on Twitter [7]. We show that our TBNB approach can effectively identify the 'who', i.e. classify Twitter users into communities. To investigate 'what' these communities have discussed, we apply our time-sensitive topic modelling approach to extract coherent topics. We finally analyse the community-related topics evaluated and selected using our proposed topic coherence metrics. Overall, we contribute to provide effective approaches to assist social scientists towards analysing political events on Twitter. These approaches include topic coherence metrics, a time-sensitive topic modelling approach and approaches for classifying the community affiliations of Twitter users. Together they make progress to study and understand the connections and dynamics among communities on Twitter. Supervisors : Iadh Ounis, Craig Macdonald, Philip Habel The thesis is available at http://theses.gla.ac.uk/41135/


2013 ◽  
Vol 31 (12) ◽  
pp. 921-934 ◽  
Author(s):  
Ruan Lakemond ◽  
Clinton Fookes ◽  
Sridha Sridharan

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Orhun Utku Aydin ◽  
Abdel Aziz Taha ◽  
Adam Hilbert ◽  
Ahmed A. Khalil ◽  
Ivana Galinovic ◽  
...  

AbstractAverage Hausdorff distance is a widely used performance measure to calculate the distance between two point sets. In medical image segmentation, it is used to compare ground truth images with segmentations allowing their ranking. We identified, however, ranking errors of average Hausdorff distance making it less suitable for applications in segmentation performance assessment. To mitigate this error, we present a modified calculation of this performance measure that we have coined “balanced average Hausdorff distance”. To simulate segmentations for ranking, we manually created non-overlapping segmentation errors common in magnetic resonance angiography cerebral vessel segmentation as our use-case. Adding the created errors consecutively and randomly to the ground truth, we created sets of simulated segmentations with increasing number of errors. Each set of simulated segmentations was ranked using both performance measures. We calculated the Kendall rank correlation coefficient between the segmentation ranking and the number of errors in each simulated segmentation. The rankings produced by balanced average Hausdorff distance had a significantly higher median correlation (1.00) than those by average Hausdorff distance (0.89). In 200 total rankings, the former misranked 52 whilst the latter misranked 179 segmentations. Balanced average Hausdorff distance is more suitable for rankings and quality assessment of segmentations than average Hausdorff distance.


2021 ◽  
Author(s):  
Tatsat R. Patel ◽  
Nandor Pinter ◽  
Seyyed M.M.J. Sarayi ◽  
Adnan H. Siddiqui ◽  
Vincent M. Tutino ◽  
...  

Author(s):  
Shibaprasad Sen ◽  
Ankan Bhattacharyya ◽  
Ram Sarkar ◽  
Kaushik Roy

The work reported in this article deals with the ground truth generation scheme for online handwritten Bangla documents at text-line, word, and stroke levels. The aim of the proposed scheme is twofold: firstly, to build a document level database so that future researchers can use the database to do research in this field. Secondly, the ground truth information will help other researchers to evaluate the performance of their algorithms developed for text-line extraction, word extraction, word segmentation, stroke recognition, and word recognition. The reported ground truth generation scheme starts with text-line extraction from the online handwritten Bangla documents, then words extraction from the text-lines, and finally segmentation of those words into basic strokes. After word segmentation, the basic strokes are assigned appropriate class labels by using modified distance-based feature extraction procedure and the MLP ( Multi-layer Perceptron ) classifier. The Unicode for the words are then generated from the sequence of stroke labels. XML files are used to store the stroke, word, and text-line levels ground truth information for the corresponding documents. The proposed system is semi-automatic and each step such as text-line extraction, word extraction, word segmentation, and stroke recognition has been implemented by using different algorithms. Thus, the proposed ground truth generation procedure minimizes huge manual intervention by reducing the number of mouse clicks required to extract text-lines, words from the document, and segment the words into basic strokes. The integrated stroke recognition module also helps to minimize the manual labor needed to assign appropriate stroke labels. The freely available and can be accessed at https://byanjon.herokuapp.com/ .


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