scholarly journals Calibration free beam hardening correction for cardiac CT perfusion imaging

2016 ◽  
Author(s):  
Jacob Levi ◽  
Rachid Fahmi ◽  
Brendan L. Eck ◽  
Anas Fares ◽  
Hao Wu ◽  
...  
Keyword(s):  
Perfusion Imaging ◽  
Cardiac Ct ◽  
Ct Perfusion ◽  
Beam Hardening ◽  
Ct Perfusion Imaging ◽  
Beam Hardening Correction ◽  
Calibration Free ◽  
Free Beam

scholarly journals Calibration‐free beam hardening correction for myocardial perfusion imaging using CT

2019 ◽  
Vol 46 (4) ◽  
pp. 1648-1662 ◽  
Author(s):  
Jacob Levi ◽  
Brendan L. Eck ◽  
Rachid Fahmi ◽  
Hao Wu ◽  
Mani Vembar ◽  
...  
Keyword(s):  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
Beam Hardening ◽  
Beam Hardening Correction ◽  
Calibration Free ◽  
Free Beam

scholarly journals Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kai Scherer ◽  
Johannes Hammel ◽  
Thorsten Sellerer ◽  
Korbinian Mechlem ◽  
Bernhard Renger ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Perfusion Imaging ◽  
Porcine Model ◽  
Ct Perfusion ◽  
Dual Energy Ct ◽  
Beam Hardening ◽  
Low Contrast ◽  
Time To Peak ◽  
Coronary Ct

Abstract Ischemic heart disease is the globally leading cause of death. When using coronary CT angiography, the functional hemodynamics within the myocardium remain uncertain. In this study myocardial CT perfusion imaging using iodine contrast agent demonstrated to strongly improve the assessment of myocardial disorders. However, a retrieval of such dynamics using Hounsfield units from conventional CT poses concerns with respect to beam-hardening effects and low contrast-to-noise ratio (CNR). Dual-energy CT offers novel approaches to overcome aforementioned limitations. Quantitative peak enhancement, perfusion, time to peak and iodine volume measurements inside the myocardium were determined resulting in 0.92 mg/ml, 0.085 mg/ml/s 17.12 s and 29.89 mg/ml*s, respectively. We report on the first extensive quantitative and iodine-based analysis of myocardial dynamics in a healthy porcine model using a dual-layer spectral CT. We further elucidate on the potential of reducing the radiation dose from 135 to 18 mGy and the contrast agent volume from 60 to 30 mL by presenting a two-shot acquisition approach and measuring iodine concentrations in the myocardium in-vivo down to 1 mg/ml, respectively. We believe that dynamic quantitative iodine perfusion imaging may be a highly sensitive tool for the precise functional assessment and monitoring of early myocardial ischemia.

Reproducibility of quantitative CT perfusion imaging

2001 ◽  
Vol 74 (882) ◽  
pp. 552-555 ◽  
Author(s):  
J H Gillard ◽  
N M Antoun ◽  
N G Burnet ◽  
J D Pickard
Keyword(s):  
Perfusion Imaging ◽  
Ct Perfusion ◽  
Quantitative Ct ◽  
Ct Perfusion Imaging
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