Adaptive optics full-field OCT: a resolution almost insensitive to aberrations (Conference Presentation)

2016 ◽  
Author(s):  
Peng Xiao ◽  
Mathias Fink ◽  
Claude Boccara
Keyword(s):  
Adaptive Optics ◽  
Full Field

Adaptive Optics and Full-field OCT: the expected gain

2018 ◽  
Author(s):  
Peng Xiao ◽  
Viacheslav Mazlin ◽  
Jules Scholler ◽  
Mathias Fink ◽  
Claude Boccara
Keyword(s):  
Adaptive Optics ◽  
Full Field ◽  
Expected Gain

scholarly journals Subaperture correlation based digital adaptive optics for full field optical coherence tomography

2013 ◽  
Vol 21 (9) ◽  
pp. 10850 ◽  
Author(s):  
Abhishek Kumar ◽  
Wolfgang Drexler ◽  
Rainer A. Leitgeb
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Optical Coherence ◽  
Full Field

scholarly journals Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics

2020 ◽  
Author(s):  
Denise Valente ◽  
Kari V. Vienola ◽  
Robert J. Zawadzki ◽  
Ravi S. Jonnal
Keyword(s):  
Adaptive Optics ◽  
High Speed ◽  
Imaging System ◽  
Optical Design ◽  
Attractive Potential ◽  
Swept Source ◽  
Full Field ◽  
Common Path ◽  
Cmos Sensor ◽  
Volumetric Images

AbstractA retinal imaging system was designed for full-field (FF) swept-source (SS) optical coherence tomography (OCT) with cellular resolution. The system incorporates a real-time adaptive optics (AO) subsystem and a very high speed CMOS sensor, and is capable of acquiring volumetric images of the retina at rates up to 1 kHz. While digital aberration correction (DAC) is an attractive potential alternative to AO, it has not yet been shown to provide resolution of cones in the fovea, where early detection of functional deficits is most critical. Here we demonstrate that FF-SS-OCT with hardware AO permits resolution of foveal cones, with volume rates adequate to measure light-evoked changes in photoreceptors. With the reference arm blocked, the system can operate as kilohertz AO flood illumination fundus camera with adjustable temporal coherence and is expected to allow measurement of light-evoked changes caused by common path interference in photoreceptor outer segments (OS). In this work, we describe the system’s optical design, characterize its performance, and demonstrate its ability to produce images of the human photoreceptor mosaic.

scholarly journals Investigating the causes of stimulus-evoked changes in cone reflectance using a combined adaptive optics SLO-OCT system

2021 ◽  
Author(s):  
Mehdi Azimipour ◽  
Denise Valente ◽  
John S Werner ◽  
Robert J Zawadzki ◽  
Ravi S Jonnal
Keyword(s):  
Adaptive Optics ◽  
High Volume ◽  
Phase Changes ◽  
Functional Responses ◽  
Full Field ◽  
Physiological Processes ◽  
Potential Applications ◽  
In Vivo Functional Imaging ◽  
Ophthalmic Disease

In vivo functional imaging of human photoreceptors is an emerging field, with compelling potential applications in basic science, translational research, and clinical management of ophthalmic disease. Measurements of light-evoked changes in the photoreceptors has been successfully demonstrated using adaptive optics (AO) coherent flood illumination (CFI), AO scanning light ophthalmoscopy (SLO), AO optical coherence tomography (OCT), and full-field OCT with digital AO (dAO). While the optical principles and data processing of these systems differ greatly, and while these differences manifest in the resulting measurements, we believe that the underlying physiological processes involved in each of those techniques are likely the same. AO CFI and AOSLO systems are more widely used than OCT systems. However, those systems produce only two-dimensional images and so, less can be said about the anatomical and physiological origins of the observed signal. OCT signal, on the other hand, provides 3D imaging but at a cost of high volume of data, making it impractical to clinical purposes. In light of this, we employed a combined AO OCT SLO system with point for point correspondence between the OCT and SLO images to measure functional responses simultaneously with both and investigate SLO retinal functional biomarkers based on OCT response. The resulting SLO images reveal reflectance changes in the cones which are consistent with those previously reported using AO CFI and AO SLO. The resulting OCT volumes show phase changes in the cone outer segment (OS) consistent with those previously reported by us and others. We recapitulate a model of the cone OS previously proposed to explain AO-CFI reflectance changes, and show how this model can be used to predict the signal in AO SLO. The limitations of the model is also discussed in this manuscript.

Mechanical Oscillations Simulation of an Adaptive Flexible Mirror

2015 ◽  
Vol 792 ◽  
pp. 546-550
Author(s):  
Feodor Kanev ◽  
Nailia Makenova ◽  
Roman Nesterov
Keyword(s):  
Adaptive Optics ◽  
Information Transfer ◽  
Control Algorithm ◽  
Active Element ◽  
Nonlinear Crystal ◽  
Phase Conjugation ◽  
Full Field ◽  
Mechanical Oscillations ◽  
Reflecting Surface ◽  
Adaptive Optics System

The whole model of adaptive optics system of energy and information transfer should include a model of an active element [1] construction of which is defined by parameters of the system and beam control algorithm. In the algorithm of full-field phase conjugation a nonlinear crystal or two flexible mirrors with a layer of free space between them are usually employed [2, 3], while a system of phase conjugation requires a flexible mirror as an active element [4]. In the paper the model of a flexible mirror is considered which takes into account dynamic oscillation of reflecting surface.

Adding the third dimension on adaptive optics retina imager thanks to full-field optical coherence tomography

2009 ◽  
Author(s):  
Marie Blavier ◽  
Leonardo Blanco ◽  
Marie Glanc ◽  
Florence Pouplard ◽  
Sarah Tick ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Optical Coherence ◽  
Full Field ◽  
The Third ◽  
Third Dimension

Retinal imaging with adaptive optics full-field OCT

2017 ◽  
Author(s):  
Peng Xiao ◽  
Mathias Fink ◽  
A. Claude Boccara
Keyword(s):  
Adaptive Optics ◽  
Retinal Imaging ◽  
Full Field

scholarly journals Full-field flicker evoked changes in parafoveal retinal blood flow

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Raymond L. Warner ◽  
Alberto de Castro ◽  
Lucie Sawides ◽  
Tom Gast ◽  
Kaitlyn Sapoznik ◽  
...  
Keyword(s):  
Adaptive Optics ◽  
Visual Stimulation ◽  
Vascular Diseases ◽  
Neurovascular Coupling ◽  
Vessel Diameter ◽  
Retinal Blood Flow ◽  
Retinal Vessels ◽  
Vascular Response ◽  
Full Field ◽  
Dual Beam

Abstract When retinal activity is increased by exposure to dynamic visual stimuli, blood vessels dilate and the flow of blood within vessels increases to meet the oxygen and glucose demands of the neurons. This relationship is termed ‘neurovascular coupling’ and it is critical for regulating control of the human retinal vasculature. In this study, we used a recently developed technique based on a dual-beam adaptive optics scanning laser ophthalmoscope to measure changes in red blood cell velocities, vessel diameter, and flow in interconnected small parafoveal retinal vessels (< 50 µm) of nine healthy participants. A full-field flicker stimulus was presented onto the retina to induce a vascular response to neural activity. Flicker stimulation increased blood velocity, vessel diameter, and therefore flow in arterioles, capillaries, and venules in all nine subjects. ANOVA and post hoc t-test showed significant increases in velocity and flow in arterioles and venules. These measurements indicate that the mechanism of neurovascular coupling systematically affects the vascular response in small retinal vessels in order to maintain hemodynamic regulation in the retina when exposed to visual stimulation, in our case flicker. Our findings may provide insight into future investigations on the impairments of neurovascular coupling from vascular diseases such as diabetic mellitus.

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