Near-infrared (NIR) fluorescence imaging of head and neck squamous cell carcinoma for fluorescence-guided surgery (Conference Presentation)

2016 ◽  
Author(s):  
Lindsay Moore ◽  
Jason M. Warram ◽  
Esther de Boer ◽  
William R. Carroll ◽  
Anthony Morlandt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Fluorescence Imaging ◽  
Squamous Cell ◽  
Near Infrared ◽  
Neck Squamous Cell Carcinoma ◽  
Guided Surgery ◽  
Nir Fluorescence ◽  
Fluorescence Guided Surgery

scholarly journals Targeting CD44v6 for fluorescence-guided surgery in head and neck squamous cell carcinoma

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Julia Odenthal ◽  
Mark Rijpkema ◽  
Desirée Bos ◽  
Esther Wagena ◽  
Huib Croes ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

EGFR-Targeted Fluorescence Guided Surgery in Head and Neck Squamous Cell Carcinoma

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 5-6
Author(s):  
J.G. de Wit ◽  
F.J. Voskuil ◽  
J. Vonk ◽  
M.D. Linssen ◽  
W.T.R. Hooghiemstra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

Fluorescence Imaging of Head and Neck Squamous Cell Carcinoma

2014 ◽  
Vol 151 (1_suppl) ◽  
pp. P56-P57
Author(s):  
Samantha J. Hauff ◽  
Sharat C. Raju ◽  
Ryan K. Orosco ◽  
Nadia Nashi ◽  
Elamprakash N. Savariar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Fluorescence Imaging ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals NIR Imaging of the Integrin-Rich Head and Neck Squamous Cell Carcinoma Using Ternary Copper Indium Selenide/Zinc Sulfide-Based Quantum Dots

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3727
Author(s):  
Ilya Yakavets ◽  
Aurelie Francois ◽  
Maelle Guiot ◽  
Nicolas Lequeux ◽  
Alexandra Fragola ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Near Infrared ◽  
Specific Binding ◽  
Neck Squamous Cell Carcinoma ◽  
Αvβ6 Integrin ◽  
3D Spheroids

The efficient intraoperative identification of cancers requires the development of the bright, minimally-toxic, tumor-specific near-infrared (NIR) probes as contrast agents. Luminescent semiconductor quantum dots (QDs) offer several unique advantages for in vivo cellular imaging by providing bright and photostable fluorescent probes. Here, we present the synthesis of ZnCuInSe/ZnS core/shell QDs emitting in NIR (~750 nm) conjugated to NAVPNLRGDLQVLAQKVART (A20FMDV2) peptide for targeting αvβ6 integrin-rich head and neck squamous cell carcinoma (HNSCC). Integrin αvβ6 is usually not detectable in nonpathological tissues, but is highly upregulated in HNSCC. QD-A20 showed αvβ6 integrin-specific binding in two-dimension (2D) monolayer and three-dimension (3D) spheroid in vitro HNSCC models. QD-A20 exhibit limited penetration (ca. 50 µm) in stroma-rich 3D spheroids. Finally, we demonstrated the potential of these QDs by time-gated fluorescence imaging of stroma-rich 3D spheroids placed onto mm-thick tissue slices to mimic imaging conditions in tissues. Overall, QD-A20 could be considered as highly promising nanoprobes for NIR bioimaging and imaging-guided surgery.

scholarly journals Fluorescence imaging to localize head and neck squamous cell carcinoma for enhanced pathological assessment

2016 ◽  
Vol 2 (2) ◽  
pp. 104-112 ◽  
Author(s):  
Jason M Warram ◽  
Esther de Boer ◽  
Gooitzen M van Dam ◽  
Lindsay S Moore ◽  
Stephanie L Bevans ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Fluorescence Imaging ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Pathological Assessment
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