Label-free vascular imaging in a spontaneous hamster cheek pouch carcinogen model for pre-cancer detection (Conference Presentation)

2016 ◽  
Author(s):  
Fangyao Hu ◽  
Robert Morhard ◽  
Heather Liu ◽  
Helen Murphy ◽  
Sina Farsiu ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Vascular Imaging ◽  
Cheek Pouch ◽  
Label Free ◽  
Hamster Cheek Pouch

scholarly journals Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model

2017 ◽  
Vol 77 (24) ◽  
pp. 7109-7119 ◽  
Author(s):  
Fangyao Hu ◽  
Hannah Martin ◽  
Amy Martinez ◽  
Jeffrey Everitt ◽  
Alaattin Erkanli ◽  
...  
Keyword(s):  
Dark Field ◽  
Cheek Pouch ◽  
Label Free ◽  
Hamster Cheek Pouch ◽  
Dark Field Imaging ◽  
Field Imaging

The Study on Oral Cancer Detection Based on 3-D OCT Image

2012 ◽  
Vol 490-495 ◽  
pp. 1797-1801
Author(s):  
Yong Hua Xuan ◽  
Chun Li ◽  
Guo Qing Cao ◽  
Ying Zhang
Keyword(s):  
Oral Cancer ◽  
Cancer Detection ◽  
Structural Information ◽  
Cheek Pouch ◽  
Noninvasive Evaluation ◽  
Hamster Cheek Pouch ◽  
High Resolution Images ◽  
Detection And Diagnosis ◽  
Early Detection And Diagnosis

We have successfully demonstrated the use of 2-D and 3-D OCT for early detection and diagnosis of oral premalignancy and malignancy. Our results demonstrate the feasibility of diagnostic imaging within the oral cavity using this modality. Noninvasive evaluation of neoplasia-related epithelial and subepithelial changes throughout carcinogenesis in the hamster cheek pouch model was achieved. OCT can clearly distinguish many histologic features such as epithelial and subepithelial change. 3-D images provide detailed structural information at any location, and may be viewed at any angle desired by the clinician. The appearance of structures imaged by OCT corresponded closely to histologic images. Given the ability to obtain high resolution images, flexible fiberoptic bronchoscopic compatibility, and in vivo noninvasive measurement, OCT has the potential to be- come a powerful method for early oral cancer detection.

scholarly journals Perchloric acid-soluble proteins from goat liver inhibit chemical carcinogenesis of Syrian hamster cheek-pouch carcinoma

1998 ◽  
Vol 79 (1) ◽  
pp. 54-58 ◽  
Author(s):  
F Ghezzo ◽  
G N Berta ◽  
B Bussolati ◽  
A Bosio ◽  
G Corvetti ◽  
...  
Keyword(s):  
Perchloric Acid ◽  
Syrian Hamster ◽  
Chemical Carcinogenesis ◽  
Soluble Proteins ◽  
Cheek Pouch ◽  
Hamster Cheek Pouch

scholarly journals Signaling via β2 Integrins Triggers Neutrophil-Dependent Alteration in Endothelial Barrier Function

2000 ◽  
Vol 191 (11) ◽  
pp. 1829-1840 ◽  
Author(s):  
Narinder Gautam ◽  
Heiko Herwald ◽  
Per Hedqvist ◽  
Lennart Lindbom
Keyword(s):  
Protein S ◽  
Endothelial Barrier ◽  
Cheek Pouch ◽  
Cross Linking ◽  
Endothelial Lining ◽  
Hamster Cheek Pouch ◽  
Cationic Protein ◽  
Edema Formation ◽  
Β2 Integrins

Activation of polymorphonuclear leukocytes (PMNs) and adhesion to the endothelial lining is a major cause of edema formation. Although known to be dependent on the function of β2 integrins (CD11/CD18), the precise mechanisms by which adherent PMNs may impair endothelial barrier capacity remain unclear. Here, the role of transmembrane signaling by β2 integrins in PMN-induced alterations in tight junctional permeability of cultured endothelial cell (EC) monolayers was investigated. PMN activation, in the absence of proinflammatory stimuli, was accomplished through antibody cross-linking of CD11b/CD18, mimicking adhesion-dependent receptor engagement. CD18 cross-linking in PMNs added to the EC monolayer provoked a prompt increase in EC permeability that coincided with a rise in EC cytosolic free Ca2+ and rearrangement of actin filaments, events similar to those evoked by chemoattractant PMN activation. Cell-free supernatant obtained after CD18 cross-linking in suspended PMNs triggered an EC response indistinguishable from that induced by direct PMN activation, and caused clear-cut venular plasma leakage when added to the hamster cheek pouch in vivo preparation. The PMN-evoked EC response was specific to β2 integrin engagement inasmuch as antibody cross-linking of l-selectin or CD44 was without effect on EC function. Our data demonstrate a causal link between outside-in signaling by β2 integrins and the capacity of PMNs to induce alterations in vascular permeability, and suggest a paracrine mechanism that involves PMN-derived cationic protein(s) in the cellular crosstalk between PMNs and ECs.

Pyran copolymer and 7,12-dimethylbenzanthraceneinduced carcinogenesis in the hamster cheek pouch

1981 ◽  
Vol 26 (10) ◽  
pp. 761-767 ◽  
Author(s):  
A.R. Gould ◽  
C.H. Miller ◽  
A.H. Kafrawy
Keyword(s):  
Cheek Pouch ◽  
Hamster Cheek Pouch
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