EGFR-directed Affibody for fluorescence-guided glioma surgery: time-dose analysis (Conference Presentation)

2016 ◽  
Author(s):  
Ana Luiza Ribeiro de Souza ◽  
Kayla Marra ◽  
Jason R. Gunn ◽  
Jonathan T. Elliott ◽  
Kimberley S. Samkoe ◽  
...  
Keyword(s):  
Glioma Surgery ◽  
Time Dose

Paternal Bisphenol A Exposure Alters Offspring Glucose Tolerance in a Time, Dose, and Sex-Specific Manner

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1363-P
Author(s):  
CETEWAYO S. RASHID ◽  
AMITA BANSAL ◽  
REBECCA A. SIMMONS
Keyword(s):  
Glucose Tolerance ◽  
Bisphenol A ◽  
Specific Manner ◽  
Time Dose

Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection

2020 ◽  
Vol 63 (6) ◽  
Author(s):  
Jorge Navarro-Bonnet ◽  
Paola Suarez-Meade ◽  
Desmond A. Brown ◽  
Kaisorn L. Chaichana ◽  
Alfredo Quinones-Hinojosa
Keyword(s):  
Aminolevulinic Acid ◽  
Sodium Fluorescein ◽  
Glioma Surgery ◽  
Glioma Resection

scholarly journals Structural and Functional Imaging in Glioma Management

Neurosurgery ◽  
2020 ◽  
Author(s):  
Bledi C Brahimaj ◽  
Ryan B Kochanski ◽  
John J Pearce ◽  
Melike Guryildirim ◽  
Carter S Gerard ◽  
...  
Keyword(s):  
Diffusion Tensor ◽  
Imaging Modalities ◽  
Hemispheric Dominance ◽  
Tumor Control ◽  
Histopathological Diagnosis ◽  
Glioma Surgery ◽  
Multiple Modalities ◽  
Advantages And Disadvantages ◽  
Multiple Imaging

Abstract The goal of glioma surgery is maximal safe resection in order to provide optimal tumor control and survival benefit to the patient. There are multiple imaging modalities beyond traditional contrast-enhanced magnetic resonance imaging (MRI) that have been incorporated into the preoperative workup of patients presenting with gliomas. The aim of these imaging modalities is to identify cortical and subcortical areas of eloquence, and their relationship to the lesion. In this article, multiple modalities are described with an emphasis on the underlying technology, clinical utilization, advantages, and disadvantages of each. functional MRI and its role in identifying hemispheric dominance and areas of language and motor are discussed. The nuances of magnetoencephalography and transcranial magnetic stimulation in localization of eloquent cortex are examined, as well as the role of diffusion tensor imaging in defining normal white matter tracts in glioma surgery. Lastly, we highlight the role of stimulated Raman spectroscopy in intraoperative histopathological diagnosis of tissue to guide tumor resection. Tumors may shift the normal arrangement of functional anatomy in the brain; thus, utilization of multiple modalities may be helpful in operative planning and patient counseling for successful surgery.

scholarly journals MS-2 Minimally invasive glioma surgery with navigation system and tubular retractor

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii2-ii3
Author(s):  
Kazuhiko Kurozumi
Keyword(s):  
Navigation System ◽  
Diffusion Tensor ◽  
Therapeutic Option ◽  
Normal Brain ◽  
Navigation Systems ◽  
Glioma Surgery ◽  
Tubular Retractor ◽  
Neuronavigation System ◽  
Magnetic Resonance Imaging Mri ◽  
Neurological Surgery

Abstract Navigation systems are reliable and safe for neurological surgery. Navigation is an attractive and innovative therapeutic option. Recently, endo and exoscopic surgeries have been gradually increasing in neurosurgery. We are currently trialing to use 4K and 8K systems to improve the accuracy and safety of our surgical procedures. Surgeries for deep-seated tumors are challenging because of the difficulty in creating a corridor and observing the interface between lesions and the normal area. In total, 315 patients underwent surgery at Okayama University between 2017 and 2019. Among them, we experienced 92 glioma surgeries using navigation systems. Preoperatively, we performed computed tomography imaging and contrast-enhanced magnetic resonance imaging (MRI) for the neuronavigation system. We experienced Curve(TM) Image Guided Surgery (BrainLab, Munich, Germany). The surgical trajectory was planned with functional MRI and diffusion tensor imaging to protect the eloquent area and critical vasculature of the brain. We used a clear plastic tubular retractor system, the ViewSite Brain Access System, for surgery of deep seated gliomas. We gently inserted and placed the ViewSite using the neuronavigation. The tumor was observed and resected through the ViewSite tubular retractor under a microscope and endoscope. If the tumor was large, we switched the ViewSite tubular retractor to brain spatulas to identify the boundary between the normal brain and lesion. We are currently using the combination of the tubular retractor and brain spatulas using navigation system. Here, we present and analyze our preoperative simulation, surgical procedure, and outcomes.

scholarly journals Ex vivo ultrasonic samples of human brain tumors in the molecular era

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Alastair J Kirby ◽  
José P Lavrador ◽  
Istvan Bodi ◽  
Francesco Vergani ◽  
Ranjeev Bhangoo ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Cellular Proliferation ◽  
Aminolevulinic Acid ◽  
Ex Vivo ◽  
Methylation Status ◽  
Protoporphyrin Ix ◽  
Intratumor Heterogeneity ◽  
Power Relationship ◽  
Surgical Biopsy ◽  
Glioma Surgery

Abstract Background Gliomas are composed of multiple clones of tumor cells. This intratumor heterogeneity contributes to the ability of gliomas to resist treatment. It is vital that gliomas are fully characterized at a molecular level when a diagnosis is made to maximize treatment effectiveness. Methods We collected ultrasonic tissue fragments during glioma surgery. Large tissue fragments were separated in the operating theater and bathed continuously in oxygenated artificial cerebrospinal fluid to keep them alive. The ex vivo tissue fragments were transferred to a laboratory and incubated in 5-aminolevulinic acid (5-ALA). 5-ALA is metabolized to Protoporphyrin IX (PpIX), which accumulates in glioma cells and makes them fluorescent. The molecular and neuropathological features of the PpIX fluorescent ultrasonic tissue fragments were studied. Results We show that PpIX fluorescence can rapidly identify tissue fragments infiltrated by glioma in the laboratory. Ultrasonic tissue fragments from the tumor core provided molecular and neuropathological information about the glioma that was comparable to the surgical biopsy. We characterized the heterogeneity within individual gliomas by studying ultrasonic tissue fragments from different parts of the tumor. We found that gliomas exhibit a power relationship between cellular proliferation and tumor infiltration. Tissue fragments that deviate from this relationship may contain foci of more malignant glioma. The methylation status of the O6-methylguanine DNA methyltransferase gene promoter varied within each glioma. Conclusions Ex vivo ultrasonic tissue fragments can be rapidly screened for glioma infiltration. They offer a viable platform to characterize heterogeneity within individual gliomas, thereby enhancing their diagnosis and treatment.

Simulated real‐time dose reconstruction for moving tumors in stereotactic liver radiotherapy

2019 ◽  
Vol 46 (11) ◽  
pp. 4738-4748 ◽  
Author(s):  
Simon Skouboe ◽  
Per Rugaard Poulsen ◽  
Casper Gammelmark Muurholm ◽  
Esben Worm ◽  
Rune Hansen ◽  
...  
Keyword(s):  
Real Time ◽  
Dose Reconstruction ◽  
Time Dose

Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence

2007 ◽  
Vol 106 (6) ◽  
pp. 1070-1074 ◽  
Author(s):  
Yoshinaga Kajimoto ◽  
Toshihiko Kuroiwa ◽  
Shin-Ichi Miyatake ◽  
Tsugumichi Ichioka ◽  
Minoru Miyashita ◽  
...  
Keyword(s):  
High Risk ◽  
Tumor Tissue ◽  
Aminolevulinic Acid ◽  
Superior Sagittal Sinus ◽  
Residual Tumor ◽  
Strong Fluorescence ◽  
Glioma Surgery ◽  
Risk Of Recurrence ◽  
Sagittal Sinus ◽  
Atypical Meningiomas

✓It has been established that fluorescence-guided resection using 5-aminolevulinic acid (5-ALA) is useful in glioma surgery. The authors report on a 65-year-old woman who had a huge atypical left-hemisphere meningioma, which extended into the skull and to the superior sagittal sinus and demonstrated fluorescence in response to administration of 5-ALA. After the tumor was removed, the operative field was observed under the fluorescent mode of a fluorescence surgical microscopy system. Several minute areas of residual tumor tissue were visualized as strong fluorescence behind the vein and sinus, in a part of the hypertrophic dura, and along the edge of the skull. These remnants were completely removed. The authors concluded that fluorescence-guided resection using 5-ALA is useful in cases of atypical meningiomas with a high risk of recurrence.

Long-term evaluation of cognition after glioma surgery in eloquent areas

2013 ◽  
Vol 116 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Djaina Satoer ◽  
Evy Visch-Brink ◽  
Marion Smits ◽  
Alfred Kloet ◽  
Caspar Looman ◽  
...  
Keyword(s):  
Glioma Surgery ◽  
Eloquent Areas ◽  
Term Evaluation
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