Quantitative modulated imaging of turbid media in the high spatial frequency domain

2016 ◽  
Author(s):  
Weihao Lin ◽  
Zili Cao ◽  
Bixin Zeng ◽  
M. Xu
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
High Spatial Frequency ◽  
Turbid Media ◽  
Modulated Imaging ◽  
Spatial Frequency Domain

Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain

2005 ◽  
Vol 30 (11) ◽  
pp. 1354 ◽  
Author(s):  
David J. Cuccia ◽  
Frederic Bevilacqua ◽  
Anthony J. Durkin ◽  
Bruce J. Tromberg
Keyword(s):  
Quantitative Analysis ◽  
Spatial Frequency ◽  
Frequency Domain ◽  
Turbid Media ◽  
Modulated Imaging ◽  
Spatial Frequency Domain

scholarly journals Halftone spatial frequency domain imaging enables kilohertz high-speed label-free non-contact quantitative mapping of optical properties for strongly turbid media

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Yanyu Zhao ◽  
Bowen Song ◽  
Ming Wang ◽  
Yang Zhao ◽  
Yubo Fan
Keyword(s):  
Optical Properties ◽  
Spatial Frequency ◽  
Frequency Domain ◽  
High Speed ◽  
Turbid Media ◽  
Wide Field ◽  
Label Free ◽  
Spatial Frequency Domain Imaging ◽  
Spatial Frequency Domain

AbstractThe ability to quantify optical properties (i.e., absorption and scattering) of strongly turbid media has major implications on the characterization of biological tissues, fluid fields, and many others. However, there are few methods that can provide wide-field quantification of optical properties, and none is able to perform quantitative optical property imaging with high-speed (e.g., kilohertz) capabilities. Here we develop a new imaging modality termed halftone spatial frequency domain imaging (halftone-SFDI), which is approximately two orders of magnitude faster than the state-of-the-art, and provides kilohertz high-speed, label-free, non-contact, wide-field quantification for the optical properties of strongly turbid media. This method utilizes halftone binary patterned illumination to target the spatial frequency response of turbid media, which is then mapped to optical properties using model-based analysis. We validate the halftone-SFDI on an array of phantoms with a wide range of optical properties as well as in vivo human tissue. We demonstrate with an in vivo rat brain cortex imaging study, and show that halftone-SFDI can longitudinally monitor the absolute concentration as well as spatial distribution of functional chromophores in tissue. We also show that halftone-SFDI can spatially map dual-wavelength optical properties of a highly dynamic flow field at kilohertz speed. Together, these results highlight the potential of halftone-SFDI to enable new capabilities in fundamental research and translational studies including brain science and fluid dynamics.

Enhanced scatter contrast color imaging of tissue: methods for comparing high spatial frequency domain and cross-polarization scatter images

2017 ◽  
Author(s):  
Mackenzie L. Carlson ◽  
David M. McClatchy ◽  
Jason R. Gunn ◽  
Jonathan T. Elliott ◽  
Keith D. Paulsen ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
High Spatial Frequency ◽  
Cross Polarization ◽  
Color Imaging ◽  
Spatial Frequency Domain
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