Ge-Sb-Se glass fiber-optics for in-vivo mid-infrared optical biopsy

2016 ◽  
Author(s):  
H. Parnell ◽  
J. H. Butterworth ◽  
H. Sakr ◽  
Z. Tang ◽  
D. Furniss ◽  
...  
Keyword(s):  
Glass Fiber ◽  
Fiber Optics ◽  
Optical Biopsy ◽  
Mid Infrared ◽  
Se Glass

Mid-infrared supercontinuum generation by pumping at normal dispersion regime of As-Se glass fiber

2018 ◽  
Vol 484 ◽  
pp. 26-29 ◽  
Author(s):  
Lei Yang ◽  
Yinsheng Xu ◽  
Junzhou Tang ◽  
Chenyang You ◽  
Yingying Wang ◽  
...  
Keyword(s):  
Glass Fiber ◽  
Supercontinuum Generation ◽  
Mid Infrared ◽  
Normal Dispersion ◽  
Dispersion Regime ◽  
Se Glass

Mid-infrared single-Mode As-S-Se glass fiber and its supercontinuum generation

2021 ◽  
Vol 567 ◽  
pp. 120925
Author(s):  
Zan Feng ◽  
Guolin Wu ◽  
Jun Wang ◽  
Jinjing Wang ◽  
Weilu Sun ◽  
...  
Keyword(s):  
Glass Fiber ◽  
Single Mode ◽  
Supercontinuum Generation ◽  
Mid Infrared ◽  
Se Glass

scholarly journals 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Jun Zhu ◽  
Hercules Rezende Freitas ◽  
Izumi Maezawa ◽  
Lee-way Jin ◽  
Vivek J. Srinivasan
Keyword(s):  
Minimally Invasive ◽  
Mouse Brain ◽  
Numerical Aperture ◽  
Optical Biopsy ◽  
Optical Coherence ◽  
Label Free ◽  
Optical Coherence Microscopy ◽  
Minimal Invasiveness ◽  
Cortical Regions

AbstractIn vivo, minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging. To address this challenge, we present an in vivo high numerical aperture optical coherence microscopy (OCM) approach that fully utilizes the water absorption window around 1700 nm, where ballistic attenuation in the brain is minimized. Key issues, including detector noise, excess light source noise, chromatic dispersion, and the resolution-speckle tradeoff, are analyzed and optimized. Imaging through a thinned-skull preparation that preserves intracranial space, we present volumetric imaging of cytoarchitecture and myeloarchitecture across the entire depth of the mouse neocortex, and some sub-cortical regions. In an Alzheimer’s disease model, we report that findings in superficial and deep cortical layers diverge, highlighting the importance of deep optical biopsy. Compared to other microscopic techniques, our 1700 nm OCM approach achieves a unique combination of intrinsic contrast, minimal invasiveness, and high resolution for deep brain imaging.

scholarly journals In vivo optical cellular diagnosis for uterine cervical or vaginal intraepithelial neoplasia using flexible gastrointestinal endocytoscopy -a prospective pilot study-

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shoko Ono ◽  
Ayako Nozaki ◽  
Kana Matsuda ◽  
Emi Takakuwa ◽  
Naoya Sakamoto ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Intraepithelial Neoplasia ◽  
Observer Agreement ◽  
Optical Biopsy ◽  
Link Type ◽  
Guided Biopsy ◽  
Vaginal Intraepithelial Neoplasia ◽  
High Level

Abstract Backgrouund For patients with any kind of atypical squamous intraepithelial lesion of the uterine cervix or vagina, colposcopy and punch biopsy are common procedures for histological determination following cytology. However, colposcopy-guided biopsy does not provide a high level of diagnostic accuracy. The aim of this study was to determine the usefulness of optical biopsy in vivo using endocytoscopy compared with conventional procedures using colposcopy. Methods Between May 2018 and March 2019, patients who were scheduled for cervical conization or mapping biopsies of the vagina were prospectively enrolled. Endocytoscopy was performed by senior endoscopists prior to scheduled procedures, and endocytoscopic images and biopsy samples were taken from the most prominent site and surrounding area of the cervical or vaginal lesions. The collection process of images was randomized and anonymous, and three doctors separately evaluated the images according to the ECA classification. ECA 4 and 5 are indicative of endoscopic malignancy. The primary endpoint was diagnostic accuracy (benign or malignant: cervical intraepithelial neoplasia (CIN) 3 or vaginal intraepithelial neoplasia (VAIN) 3 or worse) of cell images at the most prominent site in each patient. Results A total of 28 consecutive patients were enrolled. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of endocytoscopic images were 95.0% (84.8–98.6%), 87.5% (61.9–96.5%), 95.0% (84.8–98.6%), 87.5% (61.9–96.5%) and 92.9% (78.2–98.0%), respectively. Inter-observer agreement among three reviewers was 0.78 (0.08–9.88, P < 0.01). On the other hand, the accuracy of colposcopy-guided biopsy was 74.1% (64.0–84.0%). Conclusions Optical cell diagnosis of cervical or vaginal intraepithelial neoplasia using endocytoscopy provides a high level of diagnostic accuracy. Trial registration The study was registered with the UMIN database (ID: 000031712). UMIN000031712. Registered 16 March 2017,

scholarly journals Development of low‐loss lead‐germanate glass for mid‐infrared fiber optics: II. preform extrusion and fiber fabrication

2020 ◽  
Vol 104 (2) ◽  
pp. 833-850 ◽  
Author(s):  
Pengfei Wang ◽  
Alson Kwun Leung Ng ◽  
Alastair Dowler ◽  
Heike Ebendorff‐Heidepriem
Keyword(s):  
Fiber Optics ◽  
Lead Germanate ◽  
Low Loss ◽  
Germanate Glass ◽  
Mid Infrared ◽  
Fiber Fabrication

Laser system for optical biopsy and in-vivo study of the human skin

2001 ◽  
Author(s):  
Ekaterina G. Borisova ◽  
Lachezar A. Avramov
Keyword(s):  
Human Skin ◽  
Laser System ◽  
Optical Biopsy ◽  
In Vivo Study
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