scholarly journals Analysis of optical neural stimulation effects on neural networks affected by neurodegenerative diseases

2016 ◽  
Author(s):  
M. Zverev ◽  
F. Fanjul-Vélez ◽  
I. Salas-García ◽  
N. Ortega-Quijano ◽  
J. L. Arce-Diego
Keyword(s):  
Neural Networks ◽  
Neurodegenerative Diseases ◽  
Neural Stimulation ◽  
Optical Neural Stimulation

scholarly journals Optical neural stimulation modeling on degenerative neocortical neural networks

2015 ◽  
Author(s):  
M. Zverev ◽  
F. Fanjul-Vélez ◽  
I. Salas-García ◽  
J. L. Arce-Diego
Keyword(s):  
Neural Networks ◽  
Neural Stimulation ◽  
Optical Neural Stimulation

scholarly journals Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting

2014 ◽  
Vol 11 (4) ◽  
pp. 046005 ◽  
Author(s):  
T K T Nguyen ◽  
Z Navratilova ◽  
H Cabral ◽  
L Wang ◽  
G Gielen ◽  
...  
Keyword(s):  
Closed Loop ◽  
Low Noise ◽  
Neural Stimulation ◽  
Recording System ◽  
Spike Sorting ◽  
Optical Neural Stimulation

3D waveguide penetrating arrays for optical neural stimulation

2012 ◽  
Author(s):  
T. V. F. Abaya ◽  
M. Diwekar ◽  
S. Blair ◽  
P. Tathireddy ◽  
L. Rieth ◽  
...  
Keyword(s):  
Neural Stimulation ◽  
Optical Neural Stimulation

Transient optical neural stimulation in vivo

2007 ◽  
Author(s):  
Anita Mahadevan-Jansen ◽  
Jonathon D. Wells ◽  
Chris Kao ◽  
E. Duco Jansen ◽  
Peter E. Konrad
Keyword(s):  
Neural Stimulation ◽  
Optical Neural Stimulation

Targeted Optical Neural Stimulation: A New Era for Personalized Medicine

2021 ◽  
pp. 107385842110570
Author(s):  
An Ping ◽  
Li Pan ◽  
Jianmin Zhang ◽  
Kedi Xu ◽  
Kenneth E. Schriver ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Neural Stimulation ◽  
Optical Stimulation ◽  
New Era ◽  
Thermal Transients ◽  
Current State ◽  
Optical Tools ◽  
Infrared Neural Stimulation ◽  
Optical Neural Stimulation ◽  
Theoretical Foundations

Targeted optical neural stimulation comprises infrared neural stimulation and optogenetics, which affect the nervous system through induced thermal transients and activation of light-sensitive proteins, respectively. The main advantage of this pair of optical tools is high functional selectivity, which conventional electrical stimulation lacks. Over the past 15 years, the mechanism, safety, and feasibility of optical stimulation techniques have undergone continuous investigation and development. When combined with other methods like optical imaging and high-field functional magnetic resonance imaging, the translation of optical stimulation to clinical practice adds high value. We review the theoretical foundations and current state of optical stimulation, with a particular focus on infrared neural stimulation as a potential bridge linking optical stimulation to personalized medicine.

scholarly journals Using multielectrode arrays to investigate neurodegenerative effects of the amyloid-beta peptide

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Steven Schulte ◽  
Manuela Gries ◽  
Anne Christmann ◽  
Karl-Herbert Schäfer
Keyword(s):  
Alzheimer’S Disease ◽  
Neural Networks ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Amyloid Β ◽  
Long Term Potentiation ◽  
Neuronal Cultures ◽  
Amyloid Β Peptide ◽  
Multielectrode Arrays

Abstract Background Multielectrode arrays are widely used to analyze the effects of potentially toxic compounds, as well as to evaluate neuroprotective agents upon the activity of neural networks in short- and long-term cultures. Multielectrode arrays provide a way of non-destructive analysis of spontaneous and evoked neuronal activity, allowing to model neurodegenerative diseases in vitro. Here, we provide an overview on how these devices are currently used in research on the amyloid-β peptide and its role in Alzheimer’s disease, the most common neurodegenerative disorder. Main body: Most of the studies analysed here indicate fast responses of neuronal cultures towards aggregated forms of amyloid-β, leading to increases of spike frequency and impairments of long-term potentiation. This in turn suggests that this peptide might play a crucial role in causing the typical neuronal dysfunction observed in patients with Alzheimer’s disease. Conclusions Although the number of studies using multielectrode arrays to examine the effect of the amyloid-β peptide onto neural cultures or whole compartments is currently limited, they still show how this technique can be used to not only investigate the interneuronal communication in neural networks, but also making it possible to examine the effects onto synaptic currents. This makes multielectrode arrays a powerful tool in future research on neurodegenerative diseases.

Sign in / Sign up

Export Citation Format

Share Document