Systematic assessment of blood circulation time of functionalized upconversion nanoparticles in the chick embryo

2015 ◽  
Author(s):  
Annemarie Nadort ◽  
Liuen Liang ◽  
Ekaterina Grebenik ◽  
Anna Guller ◽  
Yiqing Lu ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Blood Circulation ◽  
Circulation Time ◽  
Upconversion Nanoparticles ◽  
Systematic Assessment

scholarly journals Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Hao Qi ◽  
Hao Zhou ◽  
Qiyun Tang ◽  
Jee Young Lee ◽  
Zhiyuan Fan ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Blood Circulation ◽  
Circulation Time

scholarly journals The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5072
Author(s):  
Xiaodong Li ◽  
Yanhong Sun ◽  
Lina Ma ◽  
Guifeng Liu ◽  
Zhenxin Wang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Blood Circulation ◽  
Time Window ◽  
Circulation Time ◽  
Great Success ◽  
Resonance Imaging ◽  
Enhanced Sensitivity ◽  
Magnetic Resonance Imaging Contrast

The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation.

scholarly journals Polysialic Acid Modified Liposomes for Improving Pharmacokinetics and Overcoming Accelerated Blood Clearance Phenomenon

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 834
Author(s):  
Xi Han ◽  
Ting Zhang ◽  
Mengyang Liu ◽  
Yanzhi Song ◽  
Xinrong Liu ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Polysialic Acid ◽  
Repeated Administration ◽  
The Body ◽  
Circulation Time ◽  
Blood Clearance ◽  
In Vivo Evaluation ◽  
Accelerated Blood Clearance ◽  
Abc Phenomenon

Poly (ethylene glycol) (PEG) modified nanocarriers are being used widely in the drug delivery system (DDS). However, the “accelerated blood clearance (ABC) phenomenon” was induced upon repeated administration of PEG-modified liposomes, resulting in reduced blood circulation time, and increased accumulation in liver and spleen. To avoid the unexpected phenomenon, polysialic acid (PSA) was selected to modify liposomes. PSA is a natural, highly hydrophilic polysaccharide polymer for which no receptors exists in the body. It is non-immunogenic, biodegradable and endows the conjugated bioactive macromolecule and drugs with increased circulation time in vivo. In the present study, the in vivo evaluation showed that PSA modified liposomes (PSA-Lip) afford extended blood circulation in wistar rats and beagle dogs. Moreover, the ABC phenomenon did not occur and the IgM antibody was not induced after repeated injections of PSA-Lip. These results strongly suggest that PSA modification represents a promising strategy to afford good stealth of the liposomes without evoking the ABC phenomenon.

Cerebral circulation time with ruptured intracranial aneurysms

1974 ◽  
Vol 41 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Shige-Hisa Okawara ◽  
Jun Kimura ◽  
Joo Y. Hahn
Keyword(s):  
Intracranial Aneurysms ◽  
Blood Circulation ◽  
Circulation Time ◽  
Arterial Phase ◽  
Preoperative Treatment ◽  
Content Type ◽  
Arterial Perfusion ◽  
Ruptured Intracranial Aneurysm ◽  
Ruptured Intracranial Aneurysms ◽  
Cerebral Blood Circulation

✓ The cerebral blood circulation time (CT), including the length of the arterial phase, was obtained from rapid serial angiograms in 114 patients with ruptured intracranial aneurysms. The average CT of 7.2 sec, with a mean arterial phase of 3.1 sec, was much longer than the normal average CT of 5.4 sec with its 2.4 sec arterial phase. Longer circulation times were observed with the higher Botterell grades of clinical condition, high arterial perfusion and CSF pressures, and in cases with angiographic evidence of arterial spasm, hematoma, or hydrocephalus. Values of CT greater than 8.0 sec were associated with increased mortality and morbidity and vice versa. The value of the cerebral blood circulation time as a guide to preoperative treatment and to the prognosis of cases of ruptured intracranial aneurysm is suggested.

scholarly journals Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

ACS Nano ◽  
2013 ◽  
Vol 7 (10) ◽  
pp. 8870-8880 ◽  
Author(s):  
Christopher E. Nelson ◽  
James R. Kintzing ◽  
Ann Hanna ◽  
Joshua M. Shannon ◽  
Mukesh K. Gupta ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Circulation Time ◽  
Endosome Escape

Enhanced conjugation stability and blood circulation time of macromolecular gadolinium-DTPA contrast agent

2016 ◽  
Vol 61 ◽  
pp. 659-664 ◽  
Author(s):  
Ratchapol Jenjob ◽  
Na Kun ◽  
Jung Yeon Ghee ◽  
Zheyu Shen ◽  
Xiaoxia Wu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Circulation ◽  
Circulation Time ◽  
Gadolinium Dtpa

A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous

2005 ◽  
Vol 288-289 ◽  
pp. 163-166 ◽  
Author(s):  
You Rong Duan ◽  
W.S. Liu ◽  
J. Liu ◽  
Z.R. Zhang
Keyword(s):  
Ethylene Glycol ◽  
Blood Circulation ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Circulation Time ◽  
Poly Ethylene Glycol ◽  
Systemic Blood ◽  
Model Drug ◽  
Poly Ethylene

The objective of this study was to evaluate the in vivo characteristics of poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene- glycol) (PELGE) copolymers as drug carriers. In order to test this circulation time, mitoxantrone (DHAQ) was used as a model drug in this study. DHAQ nanoparticles (DHAQ-NP) were prepared, subsequently the DHAQ-NP were evaluated by measuring the drug concentration in plasma after intravenous administration via the tail vein of mice. The circulation time of the DHAQ-NP were tested. The results showed prolonged mitoxantrone (DHAQ) residence in systemic blood circulation.

scholarly journals Upconversion Nanoparticles Decorated with Polysialic Acid for Solid Tumors Visualization In Vivo

2021 ◽  
Author(s):  
P. A. Demina ◽  
N. V. Sholina ◽  
R. A. Akasov ◽  
D. A. Khochenkov ◽  
A. V. Nechaev ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Near Infrared ◽  
Signal To Noise Ratio ◽  
Polysialic Acid ◽  
Lymphatic Drainage ◽  
Circulation Time ◽  
High Signal ◽  
Upconversion Nanoparticles ◽  
Nonspecific Protein Adsorption

Abstract Upconversion nanoparticles (UCNPs) are a promising nanoplatform for bioreagent formation for in vivo imaging, which emit UV and blue light under the action of near-infrared radiation, providing deep tissue penetration and maintaining a high signal-to-noise ratio. In the case of solid tumor visualization, the UCNP surface functionalization is required to ensure a long circulation time, biocompatibility, and non-toxicity. The effective UCNP accumulation in the solid tumors is determined by the disturbed architecture of the vascular network and lymphatic drainage. This work demonstrates an approach to the UCNP biofunctionalization with endogenous polysialic acid for in vivo bioreagent formation. Bioreagents possess a low level of nonspecific protein adsorption and macrophage uptake, which allow the prolongation of the circulation time in the bloodstream up to 3 h. This leads to an intense photoluminescent signal in the tumor.

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