Implementation and evaluation of an interictal spike detector

2015 ◽  
Author(s):  
Peter C. Horak ◽  
Stephen Meisenhelter ◽  
Markus E. Testorf ◽  
Andrew C. Connolly ◽  
Kathryn A. Davis ◽  
...  
Keyword(s):  
Interictal Spike ◽  
Spike Detector

Utilising noise to improve an interictal spike detector

2011 ◽  
Vol 201 (1) ◽  
pp. 262-268 ◽  
Author(s):  
Alexander J. Casson ◽  
Esther Rodriguez-Villegas
Keyword(s):  
Interictal Spike ◽  
Spike Detector

scholarly journals Interictal spike analysis of high-density EEG in patients with partial epilepsy

2011 ◽  
Vol 122 (6) ◽  
pp. 1098-1105 ◽  
Author(s):  
Gang Wang ◽  
Gregory Worrell ◽  
Lin Yang ◽  
Christopher Wilke ◽  
Bin He
Keyword(s):  
Partial Epilepsy ◽  
High Density ◽  
Interictal Spike ◽  
Spike Analysis

Interictal spike localization for epilepsy surgery using magnetoencephalography beamforming

2021 ◽  
Vol 132 (4) ◽  
pp. 928-937
Author(s):  
Rui Li ◽  
Chris Plummer ◽  
Simon J. Vogrin ◽  
William P. Woods ◽  
Levin Kuhlmann ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
Interictal Spike

Brain regions and epileptogenicity influence epileptic interictal spike production and propagation during NREM sleep in comparison with wakefulness

Epilepsia ◽  
2017 ◽  
Vol 59 (1) ◽  
pp. 235-243 ◽  
Author(s):  
Isabelle Lambert ◽  
Nicolas Roehri ◽  
Bernard Giusiano ◽  
Romain Carron ◽  
Fabrice Wendling ◽  
...  
Keyword(s):  
Nrem Sleep ◽  
Brain Regions ◽  
Interictal Spike

Increased interictal spike activity associated with transient slow wave trains during non-rapid eye movement sleep

2014 ◽  
Vol 13 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Péter Przemyslaw Ujma ◽  
Péter Simor ◽  
Raffaele Ferri ◽  
Dániel Fabó ◽  
Anna Kelemen ◽  
...  
Keyword(s):  
Eye Movement ◽  
Slow Wave ◽  
Spike Activity ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Interictal Spike ◽  
Wave Trains

scholarly journals Suppression of Spreading Depression of Leão in Neocortex by an N-Methyl-D-Aspartate Receptor Antagonist

1992 ◽  
Vol 19 (4) ◽  
pp. 487-491 ◽  
Author(s):  
Richard S. McLachlan
Keyword(s):  
Receptor Antagonist ◽  
Spreading Depression ◽  
Excitatory Amino Acid ◽  
Mean Amplitude ◽  
Nmda Receptor Antagonist ◽  
Chemical Stimulation ◽  
Critical Element ◽  
Rate Of Spread ◽  
Interictal Spike ◽  
Aspartate Receptor

ABSTRACT:Spreading depression has been implicated in the pathophysiology of a number of diseases such as migraine, stroke and epilepsy. The characteristics of this phenomenon were explored in neocortex of anesthetized rats. Spreading depression was produced in 10 of 15 animals using mechanical, electrical and chemical stimulation. Mean amplitude of the DC shift was -9.3 mV, mean duration at any one electrode 65 sec and rate of spread 2-5 mm/min. Spreading depression was facilitated by focal interictal spike activity induced by penicillin and completely blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist, DL-2-aminophosphonovaleric acid (APV), providing further evidence that excitatory amino acid neurotransmission is a critical element in the development or propagation of the phenomenon.

scholarly journals Biochemical Markers of Excitability in Human Neocortex

1991 ◽  
Vol 18 (S4) ◽  
pp. 640-644 ◽  
Author(s):  
A.L. Sherwin ◽  
O. Vernet ◽  
F. Dubeau ◽  
A. Olivier
Keyword(s):  
Amino Acids ◽  
Tyrosine Hydroxylase ◽  
Glutamic Acid ◽  
Aspartic Acid ◽  
Biochemical Markers ◽  
Excitatory Amino Acids ◽  
Inhibitory Neurotransmitters ◽  
Catecholamine Biosynthesis ◽  
Interictal Spike ◽  
Inhibitory Mechanisms

ABSTRACT:We measured biochemical markers of excitability in brain excised for neurosurgical therapy of epilepsy. Intraoperative electrocorticography was used to identify and compare samples from regions of persistent interictal spike discharges and areas of the cerebral convexity which were free of interictal piking. We found that interictal spiking was associated with elevated tissue levels of the excitatory amino acids glutamic acid (26%, p < 0.001) and aspartic acid (25%, p < 0.05). There was also a significant increase in the activity of the enzymes glutamic acid dehydrogenase (20%, p < 0.01) and aspartate acid aminotransferase (18%, p < 0.01) which are involved in their formation. There was no change in the levels of the inhibitory neurotransmitters GABA or taurine. We also found a significant increase in the activity of tyrosine hydroxylase (52%, p < 0.001), the rate controlling enzyme in catecholamine biosynthesis. There was a reduction in the density (Bmax) of cortical alpha-1 adrenoceptors (26%, p < 0.01) and a concommitant diminution of receptor coupled phosphatidylinositide metabolism (21%, p < 0.01). This blunting of inhibitory noradrenergic transmembrane signaling may contribute to a relative imbalance between excitatory and inhibitory mechanisms in epileptogenic neocortex.

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